Chemical Properties Uses
ChemicalBook > CAS DataBase List > 4-Fluorobenzyl bromide

4-Fluorobenzyl bromide

Chemical Properties Uses
Product Name
4-Fluorobenzyl bromide
CAS No.
459-46-1
Chemical Name
4-Fluorobenzyl bromide
Synonyms
1-(BROMOMETHYL)-4-FLUOROBENZENE;Of fluoride broMide;4-Fluorobenzyl bromi;P-FLUOROBENZYL BROMIDE;4-FLUOROBENZYL BROMIDE;α-Bromo-4-fluorotoluene;1-bromo-3-fluorotoluene;à-bromo-4-fluorotoluene;4-FLUOROBBENZYL BROMIDE;A-BROMO-4-FLUOROTOLUENE
CBNumber
CB3471414
Molecular Formula
C7H6BrF
Formula Weight
189.02
MOL File
459-46-1.mol
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4-Fluorobenzyl bromide Property

Boiling point:
85 °C15 mm Hg(lit.)
Density 
1.517 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.547(lit.)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Chloroform
form 
Liquid
Specific Gravity
1.517
color 
Clear colorless to yellow
Sensitive 
Lachrymatory
BRN 
636507
InChIKey
NVNPLEPBDPJYRZ-UHFFFAOYSA-N
CAS DataBase Reference
459-46-1(CAS DataBase Reference)
NIST Chemistry Reference
«alpha»-Bromo-4-fluorotoluene(459-46-1)
EPA Substance Registry System
4-Fluorobenzyl bromide (459-46-1)
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Safety

Hazard Codes 
C
Risk Statements 
34-36
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive/Lachrymatory
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
209538
Product name
4-Fluorobenzyl bromide
Purity
97%
Packaging
5g
Price
$42.7
Updated
2025/07/31
Sigma-Aldrich
Product number
209538
Product name
4-Fluorobenzyl bromide
Purity
97%
Packaging
25g
Price
$114
Updated
2025/07/31
TCI Chemical
Product number
F0214
Product name
4-Fluorobenzyl Bromide
Purity
>97.0%(GC)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
F0214
Product name
4-Fluorobenzyl Bromide
Purity
>97.0%(GC)
Packaging
25g
Price
$86
Updated
2025/07/31
TRC
Product number
F588610
Product name
4-Fluorobenzyl Bromide
Packaging
250g
Price
$720
Updated
2021/12/16
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4-Fluorobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.

Uses

4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.

Chemical Properties

Colorless to light yellow liqui

Uses

4-Fluorobenzyl bromide was used in the preparation of:

  • 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
  • 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
  • (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
  • 8-bromo 9-(4-fluorobenzyl) adenine
  • 8-bromo 3-(4-fluorobenzyl) adenine

Uses

4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.

Synthesis

459-56-3

459-46-1

GENERAL METHOD: Benzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL), phosphorus tribromide (0.5 mL) was added and the reaction was stirred at room temperature. Upon completion of the reaction, the target product 4-fluorobenzyl bromide was obtained in quantitative yield by conventional post-processing steps.

References

[1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Bulletin of the Chemical Society of Ethiopia, 2012, vol. 26, # 2, p. 305 - 309
[3] Tetrahedron Letters, 2016, vol. 57, # 22, p. 2430 - 2433
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002
[5] Chem, 2018, vol. 4, # 1, p. 124 - 137

4-Fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Fluorobenzyl bromide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Fluorobenzyl Bromide 459-46-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Fluorobenzyl bromide 459-46-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-22
Henan Fengda Chemical Co., Ltd
Product
4-Fluorobenzyl bromide 459-46-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25

459-46-1, 4-Fluorobenzyl bromideRelated Search:

Rocuronium bromide [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate Diethylstilbestrol Ethyl bromodifluoroacetate Fluorobenzene Ethidium bromide 4-Fluorobenzyl chloride BRETYLIUM TOSYLATE Allyl bromide Sodium bromate alpha-Chloro-o-fluorotoluene 4-n-Propoxyphenylacetylene Bromine 1,2-Bis(bromomethyl)benzene 9-BROMOFLUORENE 2-(Trifluoromethyl)benzyl bromide 1,2,4,5-TETRAKIS(BROMOMETHYL)BENZENE Methyl bromide

  • P-FLUOROBENZYL BROMIDE
  • 4-Fluoro-1-(bromomethyl)benzene
  • α-Bromo-4-fluorotoluene
  • 4-Fluorobenzyl bromi
  • BroMobenzene of fluoride
  • Of fluoride broMide
  • 1-(Bromomethyl)-4-fluorobenzene, alpha-Bromo-4-fluorotoluene
  • Toluene, α-broMo-p-fluoro- (6CI,7CI,8CI)
  • The fluorine broMine benzyl
  • ALPHA-BROMO-P-FLUOROTOLUENE
  • ALPHA-BROMO-4-FLUOROTOLUENE
  • 4-FLUOROBENZYL BROMIDE
  • 1-(BROMOMETHYL)-4-FLUOROBENZENE
  • 1-(bromomethyl)-4-fluoro-benzen
  • Benzene, 1-(bromomethyl)-4-fluoro-
  • Toluene, alpha-bromo-p-fluoro-
  • 4-fluoro(bromomethyl)benzene
  • 1-bromo-3-fluorotoluene
  • à-bromo-4-fluorotoluene
  • 4-Fluorobenzyl bromide 90%
  • 4-Fluorobenzyl Bromide p-Fluorobenzyl Bromide
  • 4-FLUOROBENZYL BROMIDE 98% (GC)
  • 4-Fluorobenzylbromide,97%
  • α-Bromo-4-fluorotoluene, 1-Bromomethyl-4-fluorobenzene
  • 4-Fluorobenzyl bromide ,98%
  • 4-FLUOROBBENZYL BROMIDE
  • A-BROMO-4-FLUOROTOLUENE
  • 4-FluorobenzylBromide&gt
  • 4-Fluorobenzyl bromide, 98%, for synthesis
  • 4-Fluorobenzyl bromide ISO 9001：2015 REACH
  • α-Bromo-p-fluorotoluene
  • 459-46-1
  • BENZYL HALIDE
  • Building Blocks
  • Aryl
  • C7
  • Halogenated Hydrocarbons
  • Organic Building Blocks
  • Benzyl
  • Fluoro-contained benzyl bromide series
  • alkyl bromide|alkyl Fluorine
  • Halogenated Heterocycles ,Pyrimidines
  • Fluorinated benzene series
  • bc0001