3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE

Product Name: 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
CAS No.: 140675-42-9
Chemical Name: 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
Synonyms: 3,5-DIFLUOROSALICYLALDEHYDE;3,5-DIFLUORO-2-HYDROXYACETOPHENONE;3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE;1-(3,5-Difluoro-2-hydroxyphenyl)ethanone;3',5'-Difluoro-2'-hydroxyacetophenone98%;3',5'-Difluoro-2'-hydroxyacetophenone 98%;3',5'-Difluoro-2'-hydroxyacetophenone,97%;1-(3,5-DIFLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;Ethanone, 1-(3,5-difluoro-2-hydroxyphenyl)-;1-(3,5-Difluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4,6-difluorophenol
CBNumber: CB3725595
Molecular Formula: C8H6F2O2
Formula Weight: 172.13
MOL File: 140675-42-9.mol

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3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Property

Melting point:: 53-55°C
Boiling point:: 220.8±35.0 °C(Predicted)
Density: 1.346±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 8.93±0.23(Predicted)
form: powder
color: Khaki/gold
CAS DataBase Reference: 140675-42-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2914500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D451703
Product name: 3'',5''-Difluoro-2''-hydroxyacetophenone
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC2826
Product name: 3',5'-Difluoro-2'-hydroxyacetophenone
Purity: 98%
Packaging: 1g
Price: $16
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2620-3-35
Product name: 3',5'-Difluoro-2'-hydroxyacetophenone
Purity: 98%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Matrix Scientific

Product number: 004372
Product name: 3',5'-Difluoro-2'-hydroxyacetophenone
Purity: 98%
Packaging: 1g
Price: $38
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD86341
Product name: 1-(3,5-Difluoro-2-Hydroxyphenyl)-Ethanone
Packaging: 1g
Price: $50
Updated: 2021/12/16

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3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

This compound can be easily obtained by Fries rearrangement of 2,4-difluorophenyl acetate with aluminium chloride without solvent at 150°, and purified by recrystallization from ethanol (80–90%) ; the 2,4-difluorophenyl acetate is prepared by reaction of acetic anhydride on 2,4-difluorophenol.

Synthesis

36914-77-9

140675-42-9

General procedure for the synthesis of 1-(3,5-difluoro-2-hydroxyphenyl)ethanone from 2,4-difluorophenyl acetate: a mixture of intermediate 362 (2 g, 11.6 mmol) and aluminum trichloride (2.8 g) was heated under argon protection at 150 °C for 30 min. After completion of the reaction, it was cooled to room temperature and ice water was added cautiously followed by dropwise addition of 1N aqueous hydrochloric acid solution. The mixture was decanted in the presence of toluene and the organic phase was separated and washed sequentially with water and saturated aqueous sodium chloride. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the solid product intermediate 363 (1.5 g). The product was characterized as follows: 1H NMR (300 MHz, CDCl3): δ 12.00 (m, 1H), 7.25 (m, 1H), 7.10 (m, 1H), 2.65 (s, 3H). ir (cm-1): 1651.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6569 - 6584
[2] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0279; 0283; 0284; 0285
[3] Patent: US6191164, 2001, B1

3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Suppliers

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View Lastest Price from 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE manufacturers

Career Henan Chemical Co

Product: 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 140675-42-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

140675-42-9, 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONERelated Search:

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 4-Fluoro-2-methylphenol 2,4-Difluorophenol 3'-Fluoroacetophenone 4-Fluorophenol 5,7-DIFLUORO-BENZOFURAN-3-ONE 5-Fluorosalicylaldehyde 3-Fluoro-2-hydroxybenzaldehyde 1-Ethyl-3,5-difluorobenzene 3''-Fluoro-2''-Hydroxyacetophenone 2-Fluorophenol 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2-ETHYL-4-FLUOROPHENOL 3',5'-Difluoroacetophenone 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE 3'',5''-Difluoro-4''-Hydroxyacetophenone 3 5-DIFLUOROSALICYLALDEHYDE 97 5,6,7,8-TETRAFLUORO-2-METHYL-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER

1-(3,5-DIFLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE

3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE

3,5-DIFLUORO-2-HYDROXYACETOPHENONE

3,5-DIFLUOROSALICYLALDEHYDE

3',5'-Difluoro-2'-hydroxyacetophenone 98%

3',5'-Difluoro-2'-hydroxyacetophenone98%

1-(3,5-Difluoro-2-hydroxyphenyl)ethanone

1-(3,5-Difluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4,6-difluorophenol

Ethanone, 1-(3,5-difluoro-2-hydroxyphenyl)-

3',5'-Difluoro-2'-hydroxyacetophenone,97%

140675-42-9

40675-42-9

Aromatic Acetophenones & Derivatives (substituted)