H-7 DIHYDROCHLORIDE

ChemicalBook > CAS DataBase List > H-7 DIHYDROCHLORIDE

Product Name: H-7 DIHYDROCHLORIDE
CAS No.: 108930-17-2
Chemical Name: H-7 DIHYDROCHLORIDE
Synonyms: H-7;H-7 DIHYDROCHLORIDE;H-7 (hydrochloride);H-7 dihydrochloride,98%;H7 dihydrochloride,H 7 dihydrochloride;Protein kinase inhibitor H-7 dihydrochloride;1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
CBNumber: CB3725838
Molecular Formula: C14H19Cl2N3O2S
Formula Weight: 364.29
MOL File: 108930-17-2.mol

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H-7 DIHYDROCHLORIDE Property

Melting point:: 215-225 °C
storage temp.: 2-8°C
solubility: H₂O: 20 mg/mL
form: Light yellow lyophilized solid
color: White to Off-White
BRN: 5840763
CAS DataBase Reference: 108930-17-2(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I7016
Product name: H-7 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $136.8
Updated: 2024/03/01

Alfa Aesar

Product number: J61697
Product name: H-7 dihydrochloride
Packaging: 10mg
Price: $165.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61697
Product name: H-7 dihydrochloride
Packaging: 50mg
Price: $721
Updated: 2023/06/20

Cayman Chemical

Product number: 21434
Product name: H-7 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21434
Product name: H-7 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $95
Updated: 2024/03/01

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H-7 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases

Uses

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Definition

ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

General Description

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (K_i = 97 μM), protein kinase A (K_i = 3.0 μM), protein kinase C (K_i = 6 μM), and protein kinase G (K_i = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

Biochem/physiol Actions

Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

storage

Store at RT

H-7 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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H-7 DIHYDROCHLORIDE Suppliers

Canada 1 China 39 Germany 1 India 2 Japan 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 4 United States 21 USA 1 Global 74

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108930-17-2, H-7 DIHYDROCHLORIDERelated Search:

1-METHANESULFONYL-PIPERAZINE 2-Methylpiperazine PIPERAZINE DIHYDROCHLORIDE 1-BENZENESULFONYL-PIPERAZINE 1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE 1,4-BIS[3-(3,4,5-TRIMETHOXYBENZOYLOXY)PROPYL]HOMOPIPERAZINE DIHYDROCHLORIDE 1,3-PHENYLENEDIAMINE DIHYDROCHLORIDE 1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE 1,4-BUTANEDIAMINE DIHYDROCHLORIDE 1-(3-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE 1,3-PROPANEDIAMINE DIHYDROCHLORIDE 1,4'-BIPIPERIDINE DIHYDROCHLORIDE,[1,4']BIPIPERIDINYL DIHYDROCHLORIDE 1,4-BENZENEDIAMINE DIHYDROCHLORIDE [1,4']BIPIPERIDINYL DIHYDROCHLORIDE 10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE 1-(3-METHYLPHENYL)PIPERAZINE DIHYDROCHLORIDE HYDRATE,1-(3-Methylphenyl)piperazine dihydrochloride 1-(4-Bromophenyl)piperazine 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

H-7 DIHYDROCHLORIDE

H-7

(+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE

1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE

(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL

(-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, DI-HCL SALT

(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE

1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl

H-7 dihydrochloride,98%

H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride

5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline Hydrochloride

H-7 (hydrochloride)

H7 dihydrochloride,H 7 dihydrochloride

5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline dihydrochloride

Protein kinase inhibitor H-7 dihydrochloride

108930-17-2

C14H19Cl2N3O2S

Cell Biology

Serine/Threonine Kinase Inhibitors

Kinase/Phosphatase Biology

Protein kinase A and protein kinase C (PKA and PKC)

BioChemical

Cell Signaling and Neuroscience

Protein Kinase Inhibitors and Activators