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H-7 DIHYDROCHLORIDE

Product Name
H-7 DIHYDROCHLORIDE
CAS No.
108930-17-2
Chemical Name
H-7 DIHYDROCHLORIDE
Synonyms
H-7;H-7 DIHYDROCHLORIDE;H-7 (hydrochloride);H-7 dihydrochloride,98%;H7 dihydrochloride,H 7 dihydrochloride;Protein kinase inhibitor H-7 dihydrochloride;1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
CBNumber
CB3725838
Molecular Formula
C14H19Cl2N3O2S
Formula Weight
364.29
MOL File
108930-17-2.mol
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H-7 DIHYDROCHLORIDE Property

Melting point:
215-225 °C
storage temp. 
2-8°C
solubility 
H2O: 20 mg/mL
form 
Light yellow lyophilized solid
color 
White to Off-White
BRN 
5840763
CAS DataBase Reference
108930-17-2(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I7016
Product name
H-7 dihydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$136.8
Updated
2024/03/01
Alfa Aesar
Product number
J61697
Product name
H-7 dihydrochloride
Packaging
10mg
Price
$165.65
Updated
2024/03/01
Alfa Aesar
Product number
J61697
Product name
H-7 dihydrochloride
Packaging
50mg
Price
$721
Updated
2023/06/20
Cayman Chemical
Product number
21434
Product name
H-7 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21434
Product name
H-7 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$95
Updated
2024/03/01
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H-7 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases

Uses

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Definition

ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

General Description

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

Biochem/physiol Actions

Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

storage

Store at RT

H-7 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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H-7 DIHYDROCHLORIDE Suppliers

Canada 1 China 36 Germany 1 India 2 Japan 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 4 United States 21 USA 1 Global 71

108930-17-2, H-7 DIHYDROCHLORIDERelated Search:

1-METHANESULFONYL-PIPERAZINE 2-Methylpiperazine PIPERAZINE DIHYDROCHLORIDE 1-BENZENESULFONYL-PIPERAZINE 1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE 1,4-BIS[3-(3,4,5-TRIMETHOXYBENZOYLOXY)PROPYL]HOMOPIPERAZINE DIHYDROCHLORIDE 1,3-PHENYLENEDIAMINE DIHYDROCHLORIDE 1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE 1,4-BUTANEDIAMINE DIHYDROCHLORIDE 1-(3-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE 1,3-PROPANEDIAMINE DIHYDROCHLORIDE 1,4'-BIPIPERIDINE DIHYDROCHLORIDE,[1,4']BIPIPERIDINYL DIHYDROCHLORIDE 1,4-BENZENEDIAMINE DIHYDROCHLORIDE [1,4']BIPIPERIDINYL DIHYDROCHLORIDE 10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE 1-(3-METHYLPHENYL)PIPERAZINE DIHYDROCHLORIDE HYDRATE,1-(3-Methylphenyl)piperazine dihydrochloride 1-(4-Bromophenyl)piperazine 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

  • H-7 DIHYDROCHLORIDE
  • H-7
  • (+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
  • 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE
  • (+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
  • 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
  • (-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, DI-HCL SALT
  • (+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
  • 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
  • 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl
  • H-7 dihydrochloride,98%
  • H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
  • Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
  • 5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline Hydrochloride
  • H-7 (hydrochloride)
  • H7 dihydrochloride,H 7 dihydrochloride
  • 5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline dihydrochloride
  • Protein kinase inhibitor H-7 dihydrochloride
  • 108930-17-2
  • C14H19Cl2N3O2S
  • Cell Biology
  • Serine/Threonine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Protein kinase A and protein kinase C (PKA and PKC)
  • BioChemical
  • Cell Signaling and Neuroscience
  • Protein Kinase Inhibitors and Activators