H-7 DIHYDROCHLORIDE
- Product Name
- H-7 DIHYDROCHLORIDE
- CAS No.
- 108930-17-2
- Chemical Name
- H-7 DIHYDROCHLORIDE
- Synonyms
- H-7;H-7 DIHYDROCHLORIDE;H-7 (hydrochloride);H-7 dihydrochloride,98%;H7 dihydrochloride,H 7 dihydrochloride;Protein kinase inhibitor H-7 dihydrochloride;1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
- CBNumber
- CB3725838
- Molecular Formula
- C14H19Cl2N3O2S
- Formula Weight
- 364.29
- MOL File
- 108930-17-2.mol
H-7 DIHYDROCHLORIDE Property
- Melting point:
- 215-225 °C
- storage temp.
- 2-8°C
- solubility
- H2O: 20 mg/mL
- form
- Light yellow lyophilized solid
- color
- White to Off-White
- BRN
- 5840763
- CAS DataBase Reference
- 108930-17-2(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- I7016
- Product name
- H-7 dihydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $136.8
- Updated
- 2024/03/01
- Product number
- J61697
- Product name
- H-7 dihydrochloride
- Packaging
- 10mg
- Price
- $165.65
- Updated
- 2024/03/01
- Product number
- J61697
- Product name
- H-7 dihydrochloride
- Packaging
- 50mg
- Price
- $721
- Updated
- 2023/06/20
- Product number
- 21434
- Product name
- H-7 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 21434
- Product name
- H-7 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $95
- Updated
- 2024/03/01
H-7 DIHYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases
Uses
H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.
Definition
ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.
General Description
A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
Biochem/physiol Actions
Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
storage
Store at RT