Cytosine

ChemicalBook > CAS DataBase List > Cytosine

Product Name: Cytosine
CAS No.: 71-30-7
Chemical Name: Cytosine
Synonyms: 4-AMinopyriMidin-2(1H)-one;Cytosin;2(1H)-Pyrimidinone, 4-amino-;Cyt;4-AMINO-2(1H)-PYRIMIDINONE;6-AMinopyriMidin-2(1H)-one;4-Amino-1H-pyrimidin-2-one;Zytosin;CYTOSINE;CITOSINA
CBNumber: CB3746093
Molecular Formula: C4H5N3O
Formula Weight: 111.1
MOL File: 71-30-7.mol

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Cytosine Property

Melting point:: >300 °C (lit.)
Boiling point:: 208.2°C (rough estimate)
Density: 0,48 g/cm³
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C
solubility: Clear to very slightly hazy colorless to faint yellow solution at 50 mg/ml in 0.5 M HCL.
form: Crystalline Powder
pka: 4.60, 12.16(at 25℃)
color: White to slightly yellow
Water Solubility: soluble
Merck: 14,2795
BRN: 2637
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: OPTASPLRGRRNAP-UHFFFAOYSA-N
LogP: -1.962 (est)
CAS DataBase Reference: 71-30-7(CAS DataBase Reference)
NIST Chemistry Reference: 2(1H)-Pyrimidinone, 4-amino-(71-30-7)
EPA Substance Registry System: 2(1H)-Pyrimidinone, 4-amino- (71-30-7)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-37/39
WGK Germany: 1
RTECS: UW7350150
Hazard Note: Irritant
TSCA: Yes
HS Code: 29335910

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C3506
Product name: Cytosine
Purity: ≥99%
Packaging: 1g
Price: $63.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1162148
Product name: Cytosine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $447
Updated: 2024/03/01

TCI Chemical

Product number: C0528
Product name: Cytosine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: C0528
Product name: Cytosine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $85
Updated: 2024/03/01

Alfa Aesar

Product number: A14731
Product name: Cytosine, 98+%
Packaging: 5g
Price: $63.5
Updated: 2024/03/01

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Cytosine Chemical Properties,Usage,Production

Description

Cytosine is pyrimidine; along with adenine and guanine they account for the fi ve nucleic acid bases. Pyrimidines are heterocyclic single-ringed compounds based on the structure of pyrimidine. Cytosinelike adenine and guanine, form nucleosides and nucleotides in RNA and DNA. When the bases combine with ribose, a ribonucleoside forms; and when it attaches to deoxyribose, a deoxyribosenucleoside is formed. Names of the nucleoside are summarized in Table 29.1.these in turn combine with phosphoryl groups, in a process called phosphorylation, to form their respective nucleotides that form nucleic acids.the nucleotides can be tri, di, and mono phosphate nucleotides similar to the way in which adenine forms ATP, ADP, and AMP.

Chemical Properties

White Solid

History

Cytosine is first isolated by hydrolysis of calf thymus tissue by Albrecht Kossel (1853–1927) and A. Neumann during 1893–1894. Thymine’s structure was published in 1900 and confi rmed over the next several years when it was synthesized by several investigators. In 1903, cytosine was synthesized by Henry Lord Wheeler (1867–1914) and Treat B. Johnson, confirming its structure. Uracil was first isolated in 1900 from yeast nucleic acid found in bovine thymus and herring sperm.the methylation of uracil produces thymine; thymine is also called 5-methyluracil because methylation takes place at the fi fth carbon in uracil to produce thymine.

Uses

Cytosine is a nucleoside used for proteomics research. It is also used as an enzyme substrate or precursor of effector molecules such as cytosine sugars.

Uses

Cytosine has been used:

for the preparation of nucleobase solutions
as a standard for high-performance liquid chromatography (HPLC)
for the estimation of global methylation rate
for nucleoside 5′-triphosphate (NTP) synthesis
purification

Uses

Widely distributed in nature; constituent of nucleic acids

Definition

ChEBI: An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4.

Definition

A nitrogenous base found in DNA and RNA. Cytosine has the pyrimidine ring structure.

Definition

cytosine: A pyrimidine derivative.It is one of the principal componentbases of nucleotides and the nucleicacids DNA and RNA.

Biological Functions

Cytosine is one of the five nitrogenous bases that make up the genetic code in DNA and RNA. Nucleic acids are essential in heredity, cellular function, and biological reactions. Cytosine can also be methylated by adding a methyl (CH3) group at the C5 position and, in this modified form, plays a vital role in epigenetics. Moreover, cytosine can be transformed into other bases, such as uracil, further elevating the importance of this nitrogenous base in epigenetics. In its epigenetically modified form, cytosine associates with changes in the cellular and developmental process, neuron cell development, and human tumor development. Cytosine, in the form of cytidine triphosphate (CTP), may be used as an enzyme co-factor. Transferring a phosphate can convert adenosine diphosphate (ADP) to ATP. ATP is a high-energy molecule that is involved in a variety of cellular functions and essential biological reactions.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

Purification Methods

Cytosine crystallises from H2O as the monohydrate which loses water on heating above 100o. Its solubility in H2O is 0.77%. UV: max 267nm ( 6,100) in H2O pH 8.8 and 275nm ( 10,400) in 0.1N HCl. [Hilbert & Johnson J Am Chem Soc 52 1152 1930, Hilbert et al. J Am Chem Soc 57 552 1935, Beistein 25 III/IV 3654.]

Structure and conformation

Cytosine is a pyrimidine containing a single heterocyclic aromatic ring, a keto group at C2, and an amine group at C4. The molecule is planar in shape. Cytosine can form three hydrogen bonds with guanine. Due to these three hydrogen bonds, the cytosine-guanine base pair has an overall higher boiling point and greater bond strength than the adenine-thymine base pair. The high melting point makes the cytosine-guanine base-pair much more resistant to denaturation. The double strand of DNA breaks down into its single constituent strands due to high temperatures.

Cytosine Preparation Products And Raw materials

Raw materials

Preparation Products

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Cytidine 5'-Diphosphocholine 4-AMINO-5-BROMO-2-PYRIMIDINOL Cidofovir Idoxuridine 5-IODOCYTOSINE

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View Lastest Price from Cytosine manufacturers

Jinan Finer Chemical Co., Ltd

Product: Cytosine 71-30-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500mt/year
Release date: 2021-07-12

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Cytosine 71-30-7
Price: US $999.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

hebei hongtan Biotechnology Co., Ltd

Product: Cytosine 71-30-7
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-05-14

71-30-7, CytosineRelated Search:

4-Cyanophenol EC 2.6.1.2 Betaine Aminopyrine Sulfamic acid ALTRENOGEST Glycine Pyrimidine 4-Hydroxy-6-aminopyrimidine 2-Hydroxypyrimidine Acetaminophen 5-Amino-o-cresol Glucosamine 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL 4-Aminopyrimidine 5-Azacytosine CYTIDINE (CYTOSINE RIBOSIDE) Fluorocytosine

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AURORA KA-682

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Cytosine (100 mg)

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Cytosine, 99+% 5GR

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Cytosine API

4-Amino-2-oxo-1,2-dihydropyrimidine 4-Amino-2(1H)-pyrimidone

6-AMinopyriMidin-2(1H)-one

Cytosine/4-AMino-2(1H)-pyriMidinone

Cytosine Vetec(TM) reagent grade, 99%

4-Aminopyrimidin-2(1H)-one, 4-Amino-1,2-dihydro-2-oxopyrimidine

Gemcitabine EP Impurity A

Zidovudine and Lamivudine Tablets ImpuritⅠ:Cytosine (4-amino-2H-pyrimidi-none)

Lamivudine Impurity Ⅳ:Cytosine (4-amino-2H-pyrimidi-none)

Gemcitabine Hydrochloride ImpuritⅠ:Cytosine (4-amino-2H-pyrimidi-none)

Cyt

Cytosin

Cytosinimine

4-amino-2H-pyrimidi-none

CYTOSINE, 99+%

CytosineForBiochemistry

2(1H)-Pyrimidinone, 4-amino- (9CI)

Cytosine,98%

2(1H)-Pyrimidinone, 4-amino-

4-AMINO-2-HYDROXYPYRIMIDINE/CYTOSINE

6-Amino-1H-pyrimidin-2-one

4-Amino-1H-pyrimidin-2-one

6-Amino-2(1H)-pyrimidinone

NSC 27787

Cytosine (8CI)

Zytosin

CITOSINA

Lamivudine EP Impurity E

Cytosine 71-30-7

Gemcitabine Hydrochloride EP impurity A -C

Gemcitabine Hydrochloride EP impurity A

Gemcitabine Impurity 1(Gemcitabine EP Impurity A)

Lamivudine Impurity 5(Lamivudine EP Impurity E)

Cytosine, 99%, for bio

Cytosine &gt

Gemcitabine impurity A CRS

Gemcitabine EP Impurity A (Cytosine, Lamivudine EP Impurity E)