ChemicalBook > CAS DataBase List > 4-Chloronicotinic acid

4-Chloronicotinic acid

Product Name
4-Chloronicotinic acid
CAS No.
10177-29-4
Chemical Name
4-Chloronicotinic acid
Synonyms
4-CHLOROPYRIDINE-3-CARBOXYLIC ACID;4-Chloronic;IFLAB-BB F1926-0029;4 - chlorine niacin;4-Chloronicotinic ac;4-Choronicotinic acid;4-chloronicotinic aci;4-chloro-nicotic acid;4-CHLORONICOTINIC ACID;4-CHLORONICOTINIC ACID,99%
CBNumber
CB4214784
Molecular Formula
C6H4ClNO2
Formula Weight
157.55
MOL File
10177-29-4.mol
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4-Chloronicotinic acid Property

Melting point:
139-143 °C
Boiling point:
301.9±22.0 °C(Predicted)
Density 
1.470±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in organic solvents at 20°C
form 
powder
pka
0.78±0.25(Predicted)
color 
White
BRN 
9255849
InChIKey
IMRGVWZLCZERSQ-UHFFFAOYSA-N
CAS DataBase Reference
10177-29-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT, KEEP COLD
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
660396
Product name
4-Chloropyridine-3-carboxylic acid
Purity
96%
Packaging
1g
Price
$58.5
Updated
2023/06/20
TRC
Product number
C380500
Product name
4-ChloronicotinicAcid
Packaging
5g
Price
$265
Updated
2021/12/16
Oakwood
Product number
013136
Product name
4-Chloronicotinic acid
Packaging
1g
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
007241
Product name
4-Chloronicotinic acid
Purity
95%
Packaging
1g
Price
$19
Updated
2021/12/16
Apolloscientific
Product number
OR6712
Product name
4-Chloronicotinic acid
Purity
99%
Packaging
5g
Price
$19
Updated
2021/12/16
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4-Chloronicotinic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

4-Chloronicotinic Acid is a building block used in a synthesis of benzocanthinones via tributyltin hydride radical induced cyclization. It is also used in a synthesis of heterocyclic analogues of xanthone.

Uses

Building block used in a synthesis of benzocanthinones via tributyltin hydride radical induced cyclization. Also used in a synthesis of heterocyclic analogues of xanthone.

Synthesis

626-61-9

124-38-9

10177-29-4

1. Neutralization reaction: Neutralize 4-chloropyridine hydrochloride using 10% NaOH solution to obtain 4-chloropyridine (1). 2. lithiation reaction: 4-chloropyridine (1) (15 mmol) was dissolved in THF (250 ml) under nitrogen protection, cooled to -78 °C, and 1.2 equivalents of lithium diisopropylammonium was slowly added (1.5 M hexane solution containing 1 equivalent of THF, ALDRICH). 3. carboxylation reaction: the resulting anion is reacted with dry CO? to produce 4-chloropyridine-3-carboxylic acid (3, i.e. 4-chloronicotinic acid). 4. Isolation and purification: The reaction mixture was treated and isolated to obtain 4-chloronicotinic acid as a colorless solid in 60-80% yield.

References

[1] Journal of Organic Chemistry, 1995, vol. 60, # 2, p. 292 - 296
[2] Patent: US2011/53975, 2011, A1. Location in patent: Page/Page column 60
[3] Patent: WO2009/87238, 2009, A2. Location in patent: Page/Page column 97; 98-99
[4] Patent: WO2005/21546, 2005, A1. Location in patent: Page/Page column 124-125
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 1869 - 1879

4-Chloronicotinic acid Preparation Products And Raw materials

Raw materials

Lithium diisopropylamide Tetrahydrofuran 4-Chloropyridinium chloride

Preparation Products

4-Amino-3-pyridinecarboxylic acid
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View Lastest Price from 4-Chloronicotinic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-Chloronicotinic acid 10177-29-4
Price
US $2.20-8.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-08
Henan Aochuang Chemical Co.,Ltd.
Product
4-Chloronicotinic acid 10177-29-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
henan kanbei chemical co.,ltd
Product
4-Chloronicotinic acid 10177-29-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2022-09-26

10177-29-4, 4-Chloronicotinic acidRelated Search:

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