4-Chloronicotinic acid
- Product Name
- 4-Chloronicotinic acid
- CAS No.
- 10177-29-4
- Chemical Name
- 4-Chloronicotinic acid
- Synonyms
- 4-CHLOROPYRIDINE-3-CARBOXYLIC ACID;4-Chloronic;IFLAB-BB F1926-0029;4 - chlorine niacin;4-Chloronicotinic ac;4-Choronicotinic acid;4-chloronicotinic aci;4-chloro-nicotic acid;4-CHLORONICOTINIC ACID;4-CHLORONICOTINIC ACID,99%
- CBNumber
- CB4214784
- Molecular Formula
- C6H4ClNO2
- Formula Weight
- 157.55
- MOL File
- 10177-29-4.mol
4-Chloronicotinic acid Property
- Melting point:
- 139-143 °C
- Boiling point:
- 301.9±22.0 °C(Predicted)
- Density
- 1.470±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in organic solvents at 20°C
- form
- powder
- pka
- 0.78±0.25(Predicted)
- color
- White
- BRN
- 9255849
- InChIKey
- IMRGVWZLCZERSQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 10177-29-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, KEEP COLD
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 660396
- Product name
- 4-Chloropyridine-3-carboxylic acid
- Purity
- 96%
- Packaging
- 1g
- Price
- $58.5
- Updated
- 2023/06/20
- Product number
- C380500
- Product name
- 4-ChloronicotinicAcid
- Packaging
- 5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 4H21-5-V7
- Product name
- 4-Chloronicotinic acid
- Packaging
- 100g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- FC57270
- Product name
- 4-Chloro-3-pyridinecarboxylic acid
- Packaging
- 100g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- JK107887
- Product name
- 4-Chloropyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $349
- Updated
- 2021/12/16
4-Chloronicotinic acid Chemical Properties,Usage,Production
Chemical Properties
White to light brown solid
Uses
4-Chloronicotinic Acid is a building block used in a synthesis of benzocanthinones via tributyltin hydride radical induced cyclization. It is also used in a synthesis of heterocyclic analogues of xanthone.
Uses
Building block used in a synthesis of benzocanthinones via tributyltin hydride radical induced cyclization. Also used in a synthesis of heterocyclic analogues of xanthone.
Synthesis
626-61-9
124-38-9
10177-29-4
1. Neutralization reaction: Neutralize 4-chloropyridine hydrochloride using 10% NaOH solution to obtain 4-chloropyridine (1). 2. lithiation reaction: 4-chloropyridine (1) (15 mmol) was dissolved in THF (250 ml) under nitrogen protection, cooled to -78 °C, and 1.2 equivalents of lithium diisopropylammonium was slowly added (1.5 M hexane solution containing 1 equivalent of THF, ALDRICH). 3. carboxylation reaction: the resulting anion is reacted with dry CO? to produce 4-chloropyridine-3-carboxylic acid (3, i.e. 4-chloronicotinic acid). 4. Isolation and purification: The reaction mixture was treated and isolated to obtain 4-chloronicotinic acid as a colorless solid in 60-80% yield.
References
[1] Journal of Organic Chemistry, 1995, vol. 60, # 2, p. 292 - 296
[2] Patent: US2011/53975, 2011, A1. Location in patent: Page/Page column 60
[3] Patent: WO2009/87238, 2009, A2. Location in patent: Page/Page column 97; 98-99
[4] Patent: WO2005/21546, 2005, A1. Location in patent: Page/Page column 124-125
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 1869 - 1879
4-Chloronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloronicotinic acid manufacturers
- Product
- 4-Chloronicotinic acid 10177-29-4
- Price
- US $2.20-8.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons
- Release date
- 2025-07-08
- Product
- 4-Chloronicotinic acid 10177-29-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- 4-Chloronicotinic acid 10177-29-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2022-09-26