ChemicalBook > CAS DataBase List > LY2409881 trihydrochloride

LY2409881 trihydrochloride

Product Name
LY2409881 trihydrochloride
CAS No.
946518-60-1
Chemical Name
LY2409881 trihydrochloride
Synonyms
LY2409881;CS-1620;LY2409881 3HCl;LY-2409881 HC'l;LY2409881 triHCl;LY-2409881 ;LY 2409881;LY2409881 trihydrochloride;LY2409881 trihydrochloride USP/EP/BP;2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide;LY2409881 trihydrochloride,Inhibitor,IκB kinase,Apoptosis,IKK,inhibit,I kappa B kinase,LY-2409881 trihydrochloride
CBNumber
CB42743099
Molecular Formula
C24H30Cl2N6OS
Formula Weight
521.51
MOL File
946518-60-1.mol
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LY2409881 trihydrochloride Property

storage temp. 
Store at -20°C
solubility 
≥59.4 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
form 
solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18774
Product name
LY2409881
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18774
Product name
LY2409881
Purity
≥98%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
18774
Product name
LY2409881
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
18774
Product name
LY2409881
Purity
≥98%
Packaging
25mg
Price
$305
Updated
2024/03/01
TRC
Product number
C370110
Product name
2-[5-Chloro-2-[[3-(4-methylpiperazin-1-yl)propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamideN-cyclopropylTrihydrochloride
Packaging
2.5mg
Price
$120
Updated
2021/12/16
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LY2409881 trihydrochloride Chemical Properties,Usage,Production

Uses

2-[5-Chloro-2-[[3-(4-methylpiperazin-1-yl)propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamide N-cyclopropyl Trihydrochloride is an inhibitor of IkB-kinase (IKK2). Small molecules that inhibits IkB-kinase and NF-κB pathways are potential anti-inflammatory drug candidate.

Biological Activity

ly2409881 is a potent and selective inhibitor of ikk2 with ic50 value of 30 nm [1].iκb kinase β (ikk2) is an enzyme that serves as a subunit of iκb kinase, which is involved in the cytokine-activated immune responses. ikk2 activates nuclear factor kappa-b kinase (nf-κb).ly2409881 is a selective ikk2 inhibitor and exhibited >10-fold selectivity over other common kinases and ikk1. in the ovarian cancer cell line skov3, ly2409881 showed moderate cytotoxicity. while coadministration of ly2409881 and tnfɑ significantly induced cells death, which suggested ly2409881 inhibited nf-κb mediated antiapoptotic signals in a tnfɑ-dependent way. in the dlbcl cell line ly10, ly2409881 (10 μm) inhibited tnfɑ-dependent phosphorylation of iκb. in the dlbcl cell line sudhl2, ly2409881 (10 μm) inhibited the nuclear signals of p50 and nf-κb. also, ly2409881 induced apoptosis in a concentration-dependent way [1].in scid-beige mice bearing ly10 cell-derived tumors, ly2409881 (50, 100 and 200 mg/kg) significantly inhibited tumor growth [1].

References

[1]. deng c, lipstein m, rodriguez r, et al. the novel ikk2 inhibitor ly2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of nf-κb. clin cancer res, 2015, 21(1): 134-145.

LY2409881 trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LY2409881 trihydrochloride manufacturers

Career Henan Chemical Co
Product
LY2409881 trihydrochloride 946518-60-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

946518-60-1, LY2409881 trihydrochlorideRelated Search:

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  • LY2409881 trihydrochloride
  • LY2409881
  • 2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
  • 2-[5-Chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
  • LY2409881 triHCl
  • LY2409881 3HCl
  • CS-1620
  • LY-2409881 HC'l
  • LY-2409881 ;LY 2409881
  • 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride
  • 2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide
  • LY2409881 trihydrochloride USP/EP/BP
  • LY2409881 trihydrochloride,Inhibitor,IκB kinase,Apoptosis,IKK,inhibit,I kappa B kinase,LY-2409881 trihydrochloride
  • 946518-60-1
  • C24H29ClN6OS3HCl
  • C24H32Cl4N6OS
  • Inhibitors