Coumarin 151

Product Name: Coumarin 151
CAS No.: 53518-15-3
Chemical Name: Coumarin 151
Synonyms: AFC;7-AMINO-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN;Coumarin 490;AKOS B000459;COUMARIN 151;Coumarine151;BUTTPARK 20\02-79;Coumarin 490. Coumarin 15;7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
CBNumber: CB4277334
Molecular Formula: C10H6F3NO2
Formula Weight: 229.16
MOL File: 53518-15-3.mol

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Coumarin 151 Property

Melting point:: 221-222 °C(lit.)
Boiling point:: 314.6±42.0 °C(Predicted)
Density: 1.4096 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Powder
pka: 1.12±0.20(Predicted)
color: Yellow
Water Solubility: Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
λmax: ≤207 nm
BRN: 4456797
CAS DataBase Reference: 53518-15-3(CAS DataBase Reference)
EPA Substance Registry System: 2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-37/39
WGK Germany: 3
TSCA: T
HazardClass: IRRITANT
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 248924
Product name: 7-Amino-4-(trifluoromethyl)coumarin
Purity: ≥99%
Packaging: 250mg
Price: $59.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 248924
Product name: 7-Amino-4-(trifluoromethyl)coumarin
Purity: ≥99%
Packaging: 1g
Price: $196
Updated: 2024/03/01

Alfa Aesar

Product number: A18400
Product name: 7-Amino-4-(trifluoromethyl)coumarin, 99%
Packaging: 0.25g
Price: $34.65
Updated: 2024/03/01

Alfa Aesar

Product number: A18400
Product name: 7-Amino-4-(trifluoromethyl)coumarin, 99%
Packaging: 1g
Price: $110
Updated: 2024/03/01

TRC

Product number: A593890
Product name: 7-Amino-4-(trifluoromethyl)coumarin
Packaging: 250mg
Price: $85
Updated: 2021/12/16

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Coumarin 151 Chemical Properties,Usage,Production

Chemical Properties

Coumarin 151 is yellow powder

Uses

Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.

Uses

7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.

Definition

ChEBI: 7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.

Purification Methods

Purify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.]

Coumarin 151 Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Zinc chloride 3-Aminophenol

Preparation Products

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Coumarin 151 Suppliers

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53518-15-3, Coumarin 151Related Search:

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53518-15-3

C10H6F3NO2

ALDEHYDE

Luminescent Compounds/Detection

Stains and Dyes

Biochemicals and Reagents

BioChemical

Scintillators

Coumarin