ChemicalBook > CAS DataBase List > Felodipine

Felodipine

Product Name
Felodipine
CAS No.
72509-76-3
Chemical Name
Felodipine
Synonyms
FEXOFENADINE HCL;Plendil;Felodipin;Agon;modip;Hydac;Spendil;CGH-869;P|endil;h154/82
CBNumber
CB4300661
Molecular Formula
C18H19Cl2NO4
Formula Weight
384.25
MOL File
72509-76-3.mol
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Felodipine Property

Melting point:
142-145°C
Boiling point:
471.5±45.0 °C(Predicted)
Density 
1.3506 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL
form 
solid
pka
2.73±0.70(Predicted)
color 
light yellow
Water Solubility 
insoluble
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
CAS DataBase Reference
72509-76-3(CAS DataBase Reference)
NIST Chemistry Reference
Felodipine(72509-76-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
US7968700
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9677
Product name
Felodipine
Purity
solid
Packaging
5mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
BP777
Product name
Felodipine
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
BP758
Product name
Felodipine impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
20MG
Price
$251
Updated
2024/03/01
Sigma-Aldrich
Product number
1269389
Product name
Felodipine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
BP758
Product name
Felodipine impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
BP758
Price
$246
Updated
2023/06/20
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Felodipine Chemical Properties,Usage,Production

Description

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemical Properties

White or Light Yellow Crystalline Powder

Originator

Astra (Sweden)

Uses

vasodilator, Ca channel blocker

Uses

Zanarnivir influenza prophylaxis and therapy

Uses

Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Manufacturing Process

Preparation of 2,3-dichlorobenzylideneacetylacetic acid-methylester.
2,3-Dichlorobenzaldehyde is reacted with methyl acetoacetate in a suitable solvent in the presence of a catalytic amount of acetic acid and piperidine. Water is azeotropically separated off during the reaction. The reaction mixture is extracted in order to remove the catalysts. The solvent is evaporated and methanol is added. The product is crystallized by cooling the solution, isolated by filtration and finally washed with methanol.

brand name

Plendil (AstraZeneca).

Therapeutic Function

Antihypertensive

General Description

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biological Activity

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

storage

+4°C

References

1) Todd and Faulds, (1992)?Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders; Drugs?44?251 2) Furukawa?et al. (1999)?Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther.?291?464

Felodipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate Methyl acetoacetate 3-Amino-2-butenoic acid ethyl ester 2,3-Dichlorobenzaldehyde Isopropyl alcohol

Preparation Products

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Felodipine Suppliers

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View Lastest Price from Felodipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Felodipine 72509-76-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-101%
Supply Ability
500KGS
Release date
2021-06-30
Hebei Weibang Biotechnology Co., Ltd
Product
Felodipine 72509-76-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Hebei Yanxi Chemical Co., Ltd.
Product
felodipine 72509-76-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-10

72509-76-3, FelodipineRelated Search:

ETHANE Dichlorodimethylsilane Dimethyl phthalate Amlodipine maleate Dimethyl carbonate Amlodipine Dimethyl fumarate N,N-Dimethylformamide Dimethyl sulfoxide Dimethyl sebacate (S)-Amlodipine Dichlorodiphenylsilane Chlorodimethylphenylsilane Amlodipine Besylate Dihydromyrcenol Dimethyl ether Felodipine Metabolite Lactone DEHYDRO FELODIPINE-13C4

  • ,ethylmethylester
  • ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica
  • 4-(2，3-Dichlorophenyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl ethyl ester
  • Fjodil：Hydac
  • P|endil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester
  • CGH-869
  • Spendil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester
  • Felodipine,4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil
  • Felodipine (300 mg)
  • Felodipine (200 mg)
  • Felodipine/Plendil
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester
  • Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Felodipine, USP
  • Felodipine API
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • 3-ethyl 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Clevidipine Butyrate iMpurity Ⅱ
  • 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • Cleviprex Impurity E
  • Plendil, 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • Clevidipine Impurity E
  • h154/82
  • modip
  • FEXOFENADINE HCL
  • 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
  • Felodipin
  • FelodipineUsp25DmfGmp
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil,
  • (RS)-Felodipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
  • Agon
  • dl-Felodipine
  • Hydac
  • Munobal
  • Splendil
  • Felodipine
  • Plendil
  • Felodipine, 98%, a selective L-type Ca2+ channel blocker
  • Clevidipine Butyrate Impurity 2
  • Felodipine, 98%, Selective L-type Ca2+ channel blocker
  • Felodipine, ≥98.0%
  • Felodipine CRS
  • Felodipine&gt
  • odipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
  • Hot selling high quality Felodipine
  • Felodipine USP/EP/BP
  • Felodipine (CGH869)
  • FelodipineQ: What is Felodipine Q: What is the CAS Number of Felodipine Q: What is the storage condition of Felodipine Q: What are the applications of Felodipine
  • Felodipine (1269389)
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  • Felodipine in Acetonitrile
  • 72509-76-3
  • 72509-76-3;8618