ChemicalBook > CAS DataBase List > Ethyl trifluoromethanesulfonate
Ethyl trifluoromethanesulfonate
- Product Name
- Ethyl trifluoromethanesulfonate
- CAS No.
- 425-75-2
- Chemical Name
- Ethyl trifluoromethanesulfonate
- Synonyms
- ETHYL TRIFLATE;Ethyl trifluoromethanesulf;Ethyltrifluormethansulfonat;Ethyl trifluoromethanesulfote;Ethyl trifluoromethesulfonate;ETHYL TRIFLUROMETHANSULFONATE;Ethyl trifluoromethylsulfonate;Ethyl trifluoroMethanesulfonat;ETHYL TRIFLUOROMETHANESULFONATE;ETHYL TRIFLURO METHANESULFONATE
- CBNumber
- CB4332659
- Molecular Formula
- C3H5F3O3S
- Formula Weight
- 178.13
- MOL File
- 425-75-2.mol
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Ethyl trifluoromethanesulfonate Property
- Boiling point:
- 115 °C (lit.)
- Density
- 1.374 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.336(lit.)
- Flash point:
- 96 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, Methanol (Slightly)
- form
- Oil
- color
- Colourless
- Specific Gravity
- 1.374
- Water Solubility
- Hydrolyzes in water.
- Sensitive
- Hygroscopic
- BRN
- 1770746
- Stability:
- Volatile
- InChIKey
- UVECLJDRPFNRRQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 425-75-2(CAS DataBase Reference)
- EPA Substance Registry System
- Methanesulfonic acid, trifluoro-, ethyl ester (425-75-2)
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Safety
- Hazard Codes
- C,T,F
- Risk Statements
- 10-34
- Safety Statements
- 16-26-36/37/39-45
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 2
- F
- 3
- Hazard Note
- Highly Toxic
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 246530
- Product name
- Ethyl trifluoromethanesulfonate
- Purity
- 99%
- Packaging
- 1g
- Price
- $22.5
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 246530
- Product name
- Ethyl trifluoromethanesulfonate
- Purity
- 99%
- Packaging
- 5g
- Price
- $57.5
- Updated
- 2024/03/01
TCI Chemical
- Product number
- T1191
- Product name
- Ethyl Trifluoromethanesulfonate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $58
- Updated
- 2024/03/01
TCI Chemical
- Product number
- T1191
- Product name
- Ethyl Trifluoromethanesulfonate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $198
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- L03383
- Product name
- Ethyl trifluoromethanesulfonate, 99%
- Packaging
- 5g
- Price
- $48.7
- Updated
- 2021/12/16
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Ethyl trifluoromethanesulfonate Chemical Properties,Usage,Production
Description
Ethyl trifluoromethanesulfonate is a cationic polymerization agent used to produce polyurethane, polyacrylate, and other synthetic resins. It is an effective drug for the treatment of HIV infection and chronic bronchitis. Ethyl trifluoromethanesulfonate has been shown to inhibit the replication of HIV-1 virus at concentrations as low as 1 μM when tested in vitro. The mechanism of this drug's anti-HIV activity is unknown and may involve the inhibition of reverse transcriptase or proteases. Ethyl trifluoromethanesulfonate can be detected in vivo up to 4 hours after administration. This drug is metabolized into trifluoroacetic acid by esterases, glycosidases, and/or oxidases.
Chemical Properties
Clear colorless to yellow liquid
Uses
Ethyl trifluoromethanesulfonate is a powerful ethylating agent. due to the strong electron-absorbing ability of trifluoromethanesulfonyl, the reactivity is much higher than that of conventional alkylation reagents such as bichloride or alkyl sulfonate.
Synthesis
Triethyl orthoformate (4.44g,30mmol) was slowly added to trifluoromethanesulfonic anhydride (8.47g,30mmol) under ice bath, transferred to 25°C for reaction, monitored by NMR for 15 min, and the reaction was completed, distilled under reduced pressure to obtain 10.15g of ethyl trifluoromethanesulfonate colorless liquid in 94% yield.
Purification Methods
The ester reacts slowly with H2O and aqueous alkali. If its IR has no OH bands (~3000 cm-1) then purify it by redistillation. If OH bands are present, then dilute with dry Et2O and shake (carefully) with aqueous NaHCO3 until effervescence ceases, then wash with H2O and dry (MgSO4), filter, evaporate and distil the residue under a slight vacuum then at atmospheric pressure in a N2 atmosphere. IT IS A POWERFUL ALKYLATING AGENT, AND THE FUMES ARE VERY TOXIC — PERFORM ALL OPERATIONS IN AN EFFICIENT FUME CUPBOARD. [Gramstad & Haszeldine J Chem Soc 173 1956, Howells & McCown Chem Rev 77 69 1977, Beilstein 3 IV 34.]
Ethyl trifluoromethanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl trifluoromethanesulfonate manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- Ethyl trifluoromethanesulfonate 425-75-2
- Price
- US $20.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 50 tons
- Release date
- 2023-09-12
Hebei Guanlang Biotechnology Co., Ltd.
- Product
- Ethyl trifluoromethanesulfonate 425-75-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-14
LY Global chemicals co.,ltd .
- Product
- Ethyl trifluoromethanesulfonate 425-75-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2023-03-09
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