FMOC-ALA-ALDEHYDE

Product Name: FMOC-ALA-ALDEHYDE
CAS No.: 146803-41-0
Chemical Name: FMOC-ALA-ALDEHYDE
Synonyms: Fmoc-Ala-CHO;FMOC-ALA-ALDEHYDE;(S)-2-(Fmoc-amino)propanal;(9H-Fluoren-9-yl)MethOxy]Carbonyl Ala-aldehyde;(S)-(9H-fluoren-9-yl)methyl 1-oxopropan-2-ylcarbamate;(9H-fluoren-9-yl)methyl N-[(2S)-1-oxopropan-2-yl]carbamate;Carbamic acid, N-[(1S)-1-methyl-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester
CBNumber: CB4342182
Molecular Formula: C18H17NO3
Formula Weight: 295.33
MOL File: 146803-41-0.mol

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FMOC-ALA-ALDEHYDE Property

Boiling point:: 479.9±28.0 °C(Predicted)
Density: 1.203±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 10.80±0.46(Predicted)
Appearance: White to off-white Solid
optical activity: 42.401 °(C=1.0 g/100ml, CHCL3)

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F594905
Product name: Fmoc-ala-aldehyde
Packaging: 100mg
Price: $70
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0006774
Product name: FMOC-ALA-ALDEHYDE
Purity: 95.00%
Packaging: 250MG
Price: $656
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0006774
Product name: FMOC-ALA-ALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $497.6
Updated: 2021/12/16

AK Scientific

Product number: V3382
Product name: Fmoc-ala-aldehyde
Packaging: 10g
Price: $1743
Updated: 2021/12/16

Ambeed

Product number: A246654
Product name: (S)-(9H-Fluoren-9-yl)methyl(1-oxopropan-2-yl)carbamate
Purity: 97%
Packaging: 100mg
Price: $51
Updated: 2021/12/16

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FMOC-ALA-ALDEHYDE Chemical Properties,Usage,Production

Uses

Fmoc-ala-aldehyde acts as an intermediate in the synthesis of α-amino aldehydes and peptide aldehydes.

Synthesis

161529-13-1

146803-41-0

To an anhydrous dichloromethane (10 mL) solution of oxalyl chloride (1.89 g, 15.0 mmol) was added anhydrous dichloromethane (10 mL) solution of dimethyl sulfoxide (1.2 g, 15.0 mmol) dropwise at -65 °C. After stirring for 30 minutes, anhydrous dichloromethane (20 mL) solution of N-fluorenylmethoxycarbonyl-L-alaninol (3.0 g, 10.0 mmol) was added slowly dropwise. After continued stirring for 2 h, triethylamine (3.0 g, 30 mmol) was added dropwise, followed by gradual warming of the reaction mixture to room temperature. Upon completion of the reaction, the reaction was quenched with water and extracted with dichloromethane (3 x 100 mL). The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the solvent was removed by concentration under reduced pressure to give the white solid product methyl (S)-(9H-fluoren-9-yl)methyl(1-oxopropan-2-yl)carbamate (2.8 g, 94.9% yield).

References

[1] Patent: WO2011/69063, 2011, A2. Location in patent: Page/Page column 82
[2] Synthetic Communications, 2007, vol. 37, # 20, p. 3493 - 3499
[3] Tetrahedron Letters, 2000, vol. 41, # 32, p. 6131 - 6135
[4] Tetrahedron Letters, 2000, vol. 41, # 9, p. 1359 - 1362
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 23, p. 5627 - 5643

FMOC-ALA-ALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-ALA-ALDEHYDE Suppliers

China 28 India 2 United States 8 Global 38

Shanghai Hanhong Scientific Co.,Ltd.

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BOC Sciences

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Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.

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Henan Alfa Chemical Co., Ltd

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146803-41-0, FMOC-ALA-ALDEHYDERelated Search:

FMOC-L-Valine FMOC-GLU(OTBU)-OH H2O Fmoc-Ile-OH FMOC-L-Methionine FMOC-PHE-OH FMOC-ASP(OTBU)-OPFP Fmoc-Lys(Boc)-OH Nalpha-FMOC-L-Asparagine Fmoc-Cys(tBu)-OH Fmoc-Leu-OH Fmoc-Tyr(tBu)-OH FMOC-Ala-OH Fmoc-Pro-OH FMOC-GLN-OH FMOC-O-tert-Butyl-L-serine Nalpha-FMOC-L-Tryptophan Fmoc-Asp(OtBu)-OH FMOC-NLE-OH

FMOC-ALA-ALDEHYDE

(S)-(9H-fluoren-9-yl)methyl 1-oxopropan-2-ylcarbamate

(9H-Fluoren-9-yl)MethOxy]Carbonyl Ala-aldehyde

Fmoc-Ala-CHO

(9H-fluoren-9-yl)methyl N-[(2S)-1-oxopropan-2-yl]carbamate

Carbamic acid, N-[(1S)-1-methyl-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester

(S)-2-(Fmoc-amino)propanal

146803-41-0