Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- Product Name
- Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- CAS No.
- 720-01-4
- Chemical Name
- Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- Synonyms
- BUTTPARK 43\57-70;Ethyl 4-Chloro-2-(trifluoromethyl)pyrimidine-5-carboxyla;ETHYL 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;Ethyl 4-chloro-2-(trifluoromethyl)-5-pyrimidinecarboxylate;4-chloro-6-ethyl-2-(trifluoroMethyl)pyriMidine-5-carboxylate;Ethyl4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate97%;Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate 97%;2-trifluoromethyl-4-chloropyrimidine-5-carboxylic acid ethyl ester;4-Chloro-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 4-chloro-2-(trifluoromethyl)-, ethyl ester
- CBNumber
- CB4399555
- Molecular Formula
- C8H6ClF3N2O2
- Formula Weight
- 254.59
- MOL File
- 720-01-4.mol
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Property
- Melting point:
- 36 °C
- Boiling point:
- 95 °C
- Density
- 1.45g/ml
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- low-melting solid
- pka
- -4.91±0.29(Predicted)
- color
- Yellow
- CAS DataBase Reference
- 720-01-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39
- Hazard Note
- Irritant
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E918843
- Product name
- Ethyl4-Chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- E918843
- Product name
- Ethyl4-Chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 003976
- Product name
- Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- 4H23-7-42
- Product name
- Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC6023
- Product name
- Ethyl4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
343-67-9
720-01-4
General procedure for the synthesis of ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate using ethyl 4-hydroxy-2-trifluoromethylpyrimidine-5-carboxylate as starting material: 1. ethyl 4-hydroxy-2-trifluoromethylpyrimidine-5-carboxylate (51.8 g) was dissolved in dichloromethane (600 mL) under ice bath conditions. 2. Oxalyl chloride (57.4 mL) was slowly added to the above solution, followed by dimethylformamide (0.2 mL) as a catalyst. 3. The reaction mixture was stirred at room temperature for 16 hours. 4. Upon completion of the reaction, the solvent was removed by rotary evaporator. 5. Toluene was added and evaporated again to completely remove residual oxalyl chloride and by-products. 6. The residue is redissolved in methylene chloride and the organic layer is washed with water to remove water-soluble impurities. 7. The organic layer was dried using anhydrous magnesium sulfate, filtered and concentrated by rotary evaporator to afford the title compound ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate as an orange oil (55.7 g, 100% yield). Product characterization data: 1H-NMR (CDCl3) δ 9.25 (1H, s), 4.51 (2H, q), 1.46 (3H, t); 13C-NMR (CDCl3) δ 126.0 (2C), 161.1, 158.1 (q, J = 39 Hz), 127.0, 118.9 (q, J = 276 Hz), 63.5, 14.4.
References
[1] Patent: US2004/167142, 2004, A1. Location in patent: Page/Page column 23
[2] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 15, p. 1645 - 1648
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Suppliers
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- Belgium
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View Lastest Price from Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate manufacturers
- Product
- Ethyl4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate 720-01-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate 720-01-4
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-14