ChemicalBook > CAS DataBase List > Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate

Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate

Product Name: Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
CAS No.: 720-01-4
Chemical Name: Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Synonyms: BUTTPARK 43\57-70;Ethyl 4-Chloro-2-(trifluoromethyl)pyrimidine-5-carboxyla;ETHYL 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;Ethyl 4-chloro-2-(trifluoromethyl)-5-pyrimidinecarboxylate;4-chloro-6-ethyl-2-(trifluoroMethyl)pyriMidine-5-carboxylate;Ethyl4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate97%;Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate 97%;2-trifluoromethyl-4-chloropyrimidine-5-carboxylic acid ethyl ester;4-Chloro-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 4-chloro-2-(trifluoromethyl)-, ethyl ester
CBNumber: CB4399555
Molecular Formula: C8H6ClF3N2O2
Formula Weight: 254.59
MOL File: 720-01-4.mol

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Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Property

Melting point:: 36 °C
Boiling point:: 95 °C
Density: 1.45g/ml
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: low-melting solid
pka: -4.91±0.29(Predicted)
color: Yellow
CAS DataBase Reference: 720-01-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
Hazard Note: Irritant
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E918843
Product name: Ethyl4-Chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: E918843
Product name: Ethyl4-Chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 003976
Product name: Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging: 1g
Price: $47
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-7-42
Product name: Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Purity: 97%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: PC6023
Product name: Ethyl4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging: 1g
Price: $60
Updated: 2021/12/16

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Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

343-67-9

720-01-4

General procedure for the synthesis of ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate using ethyl 4-hydroxy-2-trifluoromethylpyrimidine-5-carboxylate as starting material: 1. ethyl 4-hydroxy-2-trifluoromethylpyrimidine-5-carboxylate (51.8 g) was dissolved in dichloromethane (600 mL) under ice bath conditions. 2. Oxalyl chloride (57.4 mL) was slowly added to the above solution, followed by dimethylformamide (0.2 mL) as a catalyst. 3. The reaction mixture was stirred at room temperature for 16 hours. 4. Upon completion of the reaction, the solvent was removed by rotary evaporator. 5. Toluene was added and evaporated again to completely remove residual oxalyl chloride and by-products. 6. The residue is redissolved in methylene chloride and the organic layer is washed with water to remove water-soluble impurities. 7. The organic layer was dried using anhydrous magnesium sulfate, filtered and concentrated by rotary evaporator to afford the title compound ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate as an orange oil (55.7 g, 100% yield). Product characterization data: 1H-NMR (CDCl3) δ 9.25 (1H, s), 4.51 (2H, q), 1.46 (3H, t); 13C-NMR (CDCl3) δ 126.0 (2C), 161.1, 158.1 (q, J = 39 Hz), 127.0, 118.9 (q, J = 276 Hz), 63.5, 14.4.

References

[1] Patent: US2004/167142, 2004, A1. Location in patent: Page/Page column 23
[2] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 15, p. 1645 - 1648

Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Ethanol Diethyl ethoxymethylenemalonate Triethyl orthoformate Potassium carbonate Sodium Phosphorus oxitrichloride Urea Sodium ethoxide Diethyl ether Dichloromethane Trifluoroacetamidine Diethyl malonate

Preparation Products

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View Lastest Price from Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate 720-01-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Career Henan Chemical Co

Product: Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate 720-01-4
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-14

720-01-4, Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylateRelated Search:

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4-chloro-6-ethyl-2-(trifluoroMethyl)pyriMidine-5-carboxylate

4-Chloro-5-(ethoxycarbonyl)-2-(trifluoromethyl)pyrimidine, 4-Chloro-5-(ethoxycarbonyl)-2-(trifluoromethyl)-1,3-diazine

Ethyl 4-chloro-2-(trifluoromethyl)-5-pyrimidinecarboxylate

ETHYL 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

BUTTPARK 43\57-70

Ethyl 4-Chloro-2-(trifluoromethyl)pyrimidine-5-carboxyla

5-Pyrimidinecarboxylic acid, 4-chloro-2-(trifluoromethyl)-, ethyl ester

2-trifluoromethyl-4-chloropyrimidine-5-carboxylic acid ethyl ester

720-01-4

C8H6ClF3N2O2

Esters

Pyrazines, Pyrimidines & Pyridazines

Fluorine series