Disodium clodronate tetrahydrate
- Product Name
- Disodium clodronate tetrahydrate
- CAS No.
- 88416-50-6
- Chemical Name
- Disodium clodronate tetrahydrate
- Synonyms
- Clodronate (sodium salt hydrate);BONEFOS;CLASTEON;CLASTOBAN;CLODRONATE DISODIUM SALT;Ceftobiprole Impurity 11;Disodium clodronate tetrahydrate;Clodronate disodiuM(tetrehydrate);DisodiumClodronateTetrahydrate>CLODRONATE, DISODIUM, TETRAHYDRATE
- CBNumber
- CB4404653
- Molecular Formula
- CH7Cl2NaO7P2
- Formula Weight
- 286.9
- MOL File
- 88416-50-6.mol
Disodium clodronate tetrahydrate Property
- storage temp.
- 2-8°C
- solubility
- Soluble in Water (up to at least 10 mg/ml)
- form
- White solid
- color
- White
- Merck
- 14,2371
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
- InChIKey
- XWHPUCFOTRBMGS-UHFFFAOYSA-L
Safety
- RTECS
- SZ7640700
- HS Code
- 2931.39.0030
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H332Harmful if inhaled
H361Suspected of damaging fertility or the unborn child
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0000888
- Product name
- Clodronate disodium tetrahydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000888
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 233183
- Product name
- Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem
- Packaging
- 10mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- D4160
- Product name
- Disodium Clodronate Tetrahydrate
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- D4160
- Product name
- Disodium Clodronate Tetrahydrate
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $311
- Updated
- 2024/03/01
- Product number
- 16134
- Product name
- Clodronate (sodium salt hydrate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
Disodium clodronate tetrahydrate Chemical Properties,Usage,Production
Description
Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC50 = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.
Uses
Disodium Clodronate Tetrahydrate is a bisphosphonate bone growth regulator.
Definition
ChEBI: The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions nd bone pain associated with skeletal metastases.
References
1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945 2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255
Disodium clodronate tetrahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Disodium clodronate tetrahydrate Suppliers
- Tel
- --
- Fax
- --
- Service Group @ Patheon Austria
- Country
- Austria
- ProdList
- 4
- Advantage
- 58
View Lastest Price from Disodium clodronate tetrahydrate manufacturers
- Product
- Disodium clodronate tetrahydrate 88416-50-6
- Price
- US $0.00/Kg/Bag
- Min. Order
- 10g
- Purity
- 98%-101%
- Supply Ability
- 10KGS
- Release date
- 2021-07-05
- Product
- Disodium dichloromethylenebis(hydrogenphosphonate) tetrahydrate 88416-50-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-20
- Product
- Disodium clodronate tetrahydrate 88416-50-6
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-05-18