ChemicalBook > CAS DataBase List > Disodium clodronate tetrahydrate

Disodium clodronate tetrahydrate

Product Name: Disodium clodronate tetrahydrate
CAS No.: 88416-50-6
Chemical Name: Disodium clodronate tetrahydrate
Synonyms: Clodronate (sodium salt hydrate);BONEFOS;CLASTEON;CLASTOBAN;Ceftobiprole Impurity 11;Disodium clodronate tetrahydrate;Clodronate disodium salt hydrate;Clodronate disodiuM(tetrehydrate);DisodiumClodronateTetrahydrate>CLODRONATE, DISODIUM, TETRAHYDRATE
CBNumber: CB4404653
Molecular Formula: CH7Cl2NaO7P2
Formula Weight: 286.9
MOL File: 88416-50-6.mol

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Disodium clodronate tetrahydrate Property

storage temp.: 2-8°C
solubility: Soluble in Water (up to at least 10 mg/ml)
form: White solid
color: White
Water Solubility: water: 1mg/mL
Merck: 14,2371
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
InChIKey: XWHPUCFOTRBMGS-UHFFFAOYSA-L

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Safety

RTECS: SZ7640700
HS Code: 2931.39.0030

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

H361Suspected of damaging fertility or the unborn child

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000888
Product name: Clodronate disodium tetrahydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 5 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 233183
Product name: Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem
Packaging: 10mg
Price: $146
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000888
Product name: Clodronate disodium tetrahydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000888
Price: $153
Updated: 2024/03/01

TCI Chemical

Product number: D4160
Product name: Disodium Clodronate Tetrahydrate
Purity: >98.0%(T)
Packaging: 1g
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: D4160
Product name: Disodium Clodronate Tetrahydrate
Purity: >98.0%(T)
Packaging: 5g
Price: $295
Updated: 2025/07/31

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Disodium clodronate tetrahydrate Chemical Properties,Usage,Production

Description

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC₅₀ = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.

Uses

Disodium Clodronate Tetrahydrate is a bisphosphonate bone growth regulator.

Definition

ChEBI: The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions nd bone pain associated with skeletal metastases.

in vivo

Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition^[1].
Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition ^[1].

Animal Model:	C57BL/6 mice (22-30 g)^[1]
Dosage:	10 mg/kg
Administration:	Intravenous injection
Result:	Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain.

References

[1] G L PLOSKER K L G. Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease.[J]. Drugs, 1994, 47 6: 945-982. DOI:10.2165/00003495-199447060-00007
[2] P. LEHENKARI. Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.[J]. Molecular Pharmacology, 2002, 61 5 1: 1255-1262. DOI:10.1124/mol.61.5.1255

Disodium clodronate tetrahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Disodium clodronate tetrahydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Disodium clodronate tetrahydrate 88416-50-6
Price: US $0.00/Kg/Bag
Min. Order: 10g
Purity: 98%-101%
Supply Ability: 10KGS
Release date: 2021-07-05

Shanghai Standard Technology Co., Ltd.

Product: Disodium clodronate tetrahydrate 88416-50-6
Price: US $0.00/g
Min. Order: 5g
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-18

Shaanxi Dideu Medichem Co. Ltd

Product: Disodium clodronate tetrahydrate 88416-50-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 600 Tons
Release date: 2020-05-03

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Disodium clodronate tetrahydrateQ: What is Disodium clodronate tetrahydrate Q: What is the CAS Number of Disodium clodronate tetrahydrate Q: What is the storage condition of Disodium clodronate tetrahydrate Q: What are the applications of Disodium clodronate tetrahydrate

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