Description References
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Metalaxyl

Description References
Product Name
Metalaxyl
CAS No.
57837-19-1
Chemical Name
Metalaxyl
Synonyms
SPAN;METALAXIL;Acylon;Jiashuangling;N-(2,6-Dimethylphenyl)-N-(methoxyacetyl)-dl-alanine methyl ester;Bleu;axyL;Fubol;MILOR;TOKAT
CBNumber
CB4431035
Molecular Formula
C15H21NO4
Formula Weight
279.33
MOL File
57837-19-1.mol
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Metalaxyl Property

Melting point:
72-73°C
Boiling point:
422.1°C (rough estimate)
Density 
1.1083 (rough estimate)
vapor pressure 
7.5 x 10-4 Pa (25 °C)
refractive index 
1.5130 (estimate)
Flash point:
100 °C
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
1.41±0.50(Predicted)
form 
Solid
color 
Off-White to Pale Beige
Water Solubility 
0.84 g/100 mL
BRN 
2947777
CAS DataBase Reference
57837-19-1(CAS DataBase Reference)
NIST Chemistry Reference
Dl-alanine, n-(2,6-dimethylphenyl)-n-(methoxyacetyl)-, methyl ester(57837-19-1)
EPA Substance Registry System
Metalaxyl (57837-19-1)
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Safety

Hazard Codes 
Xn,F
Risk Statements 
22-43-52/53-36-20/21/22-11
Safety Statements 
13-24-37-46-61-36-26-16
RIDADR 
UN 1648 3/PG 2
WGK Germany 
2
RTECS 
AY6910000
HS Code 
29242990
Hazardous Substances Data
57837-19-1(Hazardous Substances Data)
Toxicity
LD50 in rats (mg/kg): 669 orally (Urech)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
32012
Product name
Metalaxyl
Purity
PESTANAL
Packaging
100mg
Price
$69.6
Updated
2024/03/01
Sigma-Aldrich
Product number
N12380
Product name
Metalaxyl
Purity
analytical standard
Packaging
100mg
Price
$70.7
Updated
2022/05/15
Sigma-Aldrich
Product number
89979
Product name
Metalaxyl
Purity
certified reference material, TraceCERT?
Packaging
50MG
Price
$209
Updated
2022/05/15
Cayman Chemical
Product number
25817
Product name
Metalaxyl
Purity
≥98%
Packaging
100mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
25817
Product name
Metalaxyl
Packaging
50mg
Price
$36
Updated
2024/03/01
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Metalaxyl Chemical Properties,Usage,Production

Description

Metalaxyl (chemical name: methyl N-(methoxyacetyl)-N-(2, 6-xylyl)-DL-alaninate) is an acylalanine fungicide of systemic function. It can be used for the treatment of pythium and phytophthora in many kinds of vegetables and peas. However, there are severe problem of drug resistance in current days. Metalaxyl exhibits strong activity against the mycelial growth of various sensitive fungi such as pythium splendens. The primary effect of metalaxyl seems to be related to its effect of interfering with the normal synthesis of RNA and DNA in sensitive fungi strains.

References

Kerkenaar, A. "On the antifungal mode of action of metalaxyl, an inhibitor of nucleic acid synthesis in Pythium splendens." Pesticide Biochemistry & Physiology 16.1(1981):1-13.
Fisher, David J., and A. L. Hayes. "Mode of action of the systemic fungicides furalaxyl, metalaxyl and ofurace." Pest Management Science13.3(2010):330-339.
Davidse, L. C., et al. "A comparison between the antifungal mode of action of metalaxyl, cyprofuram, benalaxyl and oxadixyl in phenylamide-sensitivity and -resistant strains. " Crop Protection 7.6(1988):347-355.
Metalaxyl showed the highest activity amongst the four fungicides against mycelial growth of sensitive strains on agar media.

Description

As an important fungicide group, acylanilides have a longer history than triazoles. Metalaxyl (44) is one of the most important fungicides in the group. It originates from the class of herbicidal chloroacetanilides, particularly metolachlor (45). Metolachlor, having a chiral carbon center and a chiral axis, is composed of four stereoisomers, the most herbicidally active one of which is the (αR, 1S)-isomer (32). For the stereoselective synthesis of this isomer, novel iridium-ferrocenyldiphosphine catalysts for the enantioselective hydrogenation of N-(2-ethyl-6-methylphenyl)- N-(1 -methoxymethyl)-ethylidene-amine are reported. In the most effective approach, the catalyst is generated in situ from [Ir(cod)Cl]2(cod = cyclooctadiene) and the ferrocenyldiphosphine ligand (R)-(S)-PPF-P(3,5-xyl)2 (46) (33).When the substrate to catalyst ratio is 106, the conversion is complete in 2 to 3 h, producing metolachlor in optical yields over 80% (34).

Chemical Properties

Pale Beige Solid

Chemical Properties

Combustible, white crystalline solid or powder. Odorless.

Uses

Systemic fungicide used to control a variety of diseases on a wide range of temperate, subtropical and tropical crops.

Uses

Metalaxyl is used for the control of air-borne pathogens by foliar application and of soil-borne pathogens by soil application on a wide range of crops. It is particularly useful against Oomycetes including soil-borne Phytophthora diseases.

Uses

Agricultural fungicide. Phenylamide fungicide or use in food crops, shrubs and turf.

Definition

ChEBI: Methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate is an alanine derivative that is methyl alaninate in which one of the hydrogens attached to the nitrogen is substituted by a methoxyacetyl group, while the other is substituted by a 2,6-dimethylphenyl group. It is an alanine derivative, an aromatic amide, a carboxamide, an ether and a methyl ester.

Hazard

Moderately toxic by ingestion.

Agricultural Uses

Fungicide: Metalaxyl is used as a systemic fungicide on a variety of food and non-food crops including tobacco, turf and conifers, and ornamentals. Used in combination with fungicides of different mode of action as a foliar spray on tropical and subtropical crops; as a seed treatment to control downy mildew; and as a soil fumigant to control soilborne pathogens.

Trade name

AGROX® PREMIERE; ALLEGIENCE®; APRON®; CG 117®; CGA-48988®; CHLORAXYL®; COTGUARD®; EPERON®; DELTA-COAT; FOLIO® GOLD; GAUCHO®; KODIAK®; METALAXIL®; METAXANIN®; PACE®; PREVAIL®; RAXIL® (tebu- conazole + metalaxyl); RIDOMIL® GOLD/BRAVO®; RIDOMIL®; RIDOMIL 2E®; SUBDUE®

Pharmacology

In mycelium of Phytophthora megasperma,metalaxyl affected primarily rRNA synthesis (polymerase I), whereas mRNA was much less sensitive; therefore, inhibition of rRNA synthesis is considered as the primary site of action of PAFs (23).
The PAFs exhibit strong preventive and curative activity. They affect especially hyphal growth (inside and outside the plant tissue) as well as haustorium and spore formation (15). Although not fully utilized for resistance management reasons, PAFs also exhibit strong eradicative and antisporulant activity in the disease cycle of target pathogens. On the other hand, PAFs do not inhibit the early stages in the disease cycle like zoospore release, spore germination, and penetration of the host tissue (15). Because spores contain many ribosomes to support early growth stages, RNA synthesis is fully operating only after spore germination; later development stages are therefore most sensitive to PAFs (23). As a consequence of RNA inhibition, the precursors of RNA synthesis (i.e., nucleoside triphosphates) are accumulated; they activate β-1,3-glucansynthetases, which are involved in cell wall formation (23). Metalaxyl-treated hyphae often produce thicker cell walls than do untreated ones.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Metalaxyl is phenylamide systemic fungicide used on a variety of food and nonfood crops including tobacco, turf and conifers, and ornamentals. Used in combination with fungicides of different mode of action as a foliar spray on tropical and subtropical crops; as a seed treatment to control downy mildew; and as a soil fumigant to control soil-borne pathogens. Banned for use in EU.

Environmental Fate

Soil. Little information is available on the degradation of metalaxyl in soil; however, Sharom and Edgington (1986) reported metalaxyl acid as a possible metabolite. Repeated applications of metalaxyl decreases its persistence. Following an initial application, the average half-life was 28 days. After repeated applications, the half-life decreased to 14 days (Bailey and Coffey, 1985).
Carsel et al. (1986) studied the persistence of metalaxyl in various soil types. The application rate was 2.2 kg/ha. In a fine sand, metalaxyl concentrations at soil depths of 15, 20, 45 and 60 cm were 100, 150, 100 and 75 ppb, respectively, 55 days after
Plant. In plants, metalaxyl undergoes ring oxidation, methyl ester hydrolysis, ether cleavage, ring methyl hydroxylation and N-dealkylation (Owen and Donzel, 1986). Metalaxyl acid was identified as a hydrolysis product in both sunflower leaves an
In pigeon peas, metalaxyl may persist up to 12 days (Indira et al., 1981; Chaube et al., 1984).

Metabolic pathway

O-Demethylation is one of the major routes of metalaxyl degradation in the plant cell suspension culture. Although hydroxylation of methyl groups in the phenyl ring predominates in both lettuce and grapes, species differences are evident in grapes, whereas N-dealkylation and aryl hydroxylation are less important in lettuce. Two isomeric metabolites of methyl hydroxylation and the hydroxylated metabolite of the phenyl ring are identified as fungus metabolites. By UV irradiation of metalaxyl in aqueous solution, two rearrangement products of the N-acyl group to the 4-position on the phenyl ring are identified.

Metabolism

The degradation pathways of pesticides are published in the "FAO Plant Production and Protection Papers." Because the degradation pathways are similar for all PAF). In plants, metalaxyl is metabolized by four types of phase I reaction to form eight metabolites; at phase II, most of the metabolites are sugar-conjugated. The types of reaction in phase I are hydroxylation at the phenyl ring, oxidation of one of the tolylic methyl groups (Formula d), hydrolysis of the methyl ester (Formula e), and ether cleavage (Formula b). In phases II and III, there is also a dealkylation of the nitrogen (Formula l), in addition to the combination of the above-mentioned reaction types forming the compounds of Formulas f, h, and m. In mammals, following oral administration, metalaxyl is rapidly absorbed and rapidly and almost completely eliminated with urine and feces. Metabolism proceeds via the same degradation pathways as in plants, leading to products containing an oxidized tolylic methyl group with or without the hydrolyzed ester function (Formulas d, h, and i, respectively) containing a dealkylated nitrogen and a hydroxy group formed by ether cleavage (Formula l via b or e/f), containing an oxalyl function formed by ether cleavage followed by oxidation of the generated alcohol (Formula c), and containing the hydroxylated phenyl ring (Formula a). Residues in tissues were generally low, and there was no evidence for accumulation or retention of metalaxyl or its metabolites. In soil, similar degradation products are found as in plants and animals with the exception of three additional products of Formulas k, n, and g.

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Toxicity evaluation

If used according to label recommendations, PAFs are considered to be safe to humans, animals, and the environment. The active ingredients represent only low-to-moderate acute oral and dermal hazard to rats, mice, and rabbits. The compounds do not exhibit mutagenic, oncogenic, and teratogenic hazards. No or only weak (furalaxyl, ofurace) skin irritant potential exists in rabbits and no skin sensitization is present in guinea pigs, whereas some compounds are weak to serious eye irritants in rabbits (except benalaxyl and oxadixyl). In long-term toxicity studies, the "no-observableeffect level" (NOEL) in rats is 2.5 mg/kg body weight/day for metalaxyl, metalaxyl-M, and ofurace; 5 mg/kg for benalaxyl; and 11 mg/kg for oxadixyl, whereas in dogs, the NOEL is 8.0 mg/kg body weight/day for metalaxyl and metalaxyl-M, 7 mg/kg for benalaxyl, and 12 mg/kg for oxadixyl. Using a safety factor of 100, the "acceptable daily intake" (ADI) for PAFs ranges from 0.025 to 0.11 mg/kg. The PAFs are unlikely to pose any toxicological risk to birds (bobwhite quail, mallard ducks), fish (rainbow trout, carp), honeybees, earthworms, Daphnia, and algae. The observed LD50 (LC, EC) values are very favorable for all PAFs; only benalaxyl shows lower figures in respect to earthworm, Daphnia, and algae.

Degradation

Metalaxyl is very stable in neutral and acidic media at room temperature and it is reasonably stable to aqueous photolysis. Its calculated half-lives in buffers at 25 °C below pH 7 are <3 years and at pH 9, 12 weeks. Only at pH 11 was measurable hydrolysis seen (half-life 1.6 days) (Melkebeke et al., 1986). Thus environmental degradation can be expected to be slow.
[14C-phenyl]Metalaxy1ir radiated in aqueous solution with UV light at 30 °C was degraded with a half-life of 2-3 days at four pH values between 2.8 and 8.8. Acetone (1%) accelerated the rate of decomposition. Two rearrangement products (2 and 3) were isolated at pH 6.8; these accounted for 3 and 6% of the radioactivity, respectively. Irradiation of 2 showed that it was a precursor of compound 3 (Yao et al., 1989). Though these products appear to be unusual, there is a precedent for such reactions and the structures were determined by 1H and 13C NMR spectroscopy.
Decomposition under simulated sunlight was slower with a half-life of 297 days (Pirisi et al., 1996). Amide bond cleavage and N-dealkylation to compounds 4 and 5 was reported. The dimethylaniline (6) was a putative product but a separate experiment showed that it was degraded at a higher rate than the parent and so was not observed from metalaxyl. The products are shown in Scheme 1.

Incompatibilities

Incompatible with alkaline materials, strong acids, oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).

Waste Disposal

Small amounts may be destroyed by alkaline hydrolysis. Admixture with alkali can be followed by soil burial. Larger quantities can be disposed of by incineration in admixture with acetone or xylene and using effluent gas scrubbing. Do not reuse empty container; proper disposal required.

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View Lastest Price from Metalaxyl manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Metalaxyl 57837-19-1
Price
US $1000.00-400.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12
Hebei Dangtong Import and export Co LTD
Product
Metalaxyl 57837-19-1
Price
US $6540.00-6000.00/Tons
Min. Order
1Tons
Purity
99.99%
Supply Ability
200Tons
Release date
2023-04-11
qingdao trust agri chemical co.,ltd
Product
Metalaxyl 57837-19-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1
Release date
2024-06-28

57837-19-1, MetalaxylRelated Search:


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