imidazo[1,2-a]pyridine-6-carboxylic acid
- Product Name
- imidazo[1,2-a]pyridine-6-carboxylic acid
- CAS No.
- 139022-25-6
- Chemical Name
- imidazo[1,2-a]pyridine-6-carboxylic acid
- Synonyms
- EOS-60803;Olprinone Impurity 32;Imidazo[1,2-a]pyridine-6-...;6-Carboxyimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine-6-carboxylicAci;6-imidazo[2,1-f]pyridinecarboxylic acid;iMidazo[1,2-a]pyridin-6-carboxylic acid;imidazo[2,1-f]pyridine-6-carboxylic acid;IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID;H-iMidazo[1,2-a]pyridin-6-carboxylic acid
- CBNumber
- CB4460305
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 139022-25-6.mol
imidazo[1,2-a]pyridine-6-carboxylic acid Property
- Melting point:
- 250
- Density
- 1.41
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 0.67±0.41(Predicted)
- form
- Solid
- color
- Pale Beige to Light Beige
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H6N2O2/c11-8(12)6-1-2-7-9-3-4-10(7)5-6/h1-5H,(H,11,12)
- InChIKey
- ONOJJCTXSDBVSP-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1C=C(C(O)=O)C=C2
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 22-26-36/37/39-36/37
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- I387580
- Product name
- Imidazo[1,2-a]pyridine-6-carboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H21-1-D5
- Product name
- Imidazo[1,2-a]pyridine-6-carboxylic acid
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 045476
- Product name
- Imidazo[1,2-a]pyridine-6-carboxylic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 4H21-1-D5
- Product name
- Imidazo[1,2-a]pyridine-6-carboxylic acid
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $64
- Updated
- 2021/12/16
- Product number
- Y7487
- Product name
- H-Imidazo[1,2-a]pyridine-6-carboxylicacid
- Packaging
- 250mg
- Price
- $71
- Updated
- 2021/12/16
imidazo[1,2-a]pyridine-6-carboxylic acid Chemical Properties,Usage,Production
Uses
Imidazo[1,2-a]pyridine-6-carboxylic acid is a brown solid that should be stored sealed at room temperature and away from light. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
1314777-15-5
139022-25-6
Step 2. Imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride (170 g) was dissolved in water (600 mL) and heated until completely dissolved to form a clarified solution. Subsequently, the pH was adjusted to 5-6 by slowly adding 2 M NaOH aqueous solution. the reaction mixture was cooled to 0 °C in an ice-water bath. The precipitate precipitated was collected by vacuum filtration, washed with ethanol and dried under vacuum to afford the target product imidazo[1,2-a]pyridine-6-carboxylic acid (107.2 g, 77% yield) as a light yellow powder. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI+): 1H NMR δ 13.76-12.82 (br, 1H), 9.28 (s, 1H), 8.10 (s, 1H), 7.68 (s, 1H), 7.64-7.56 (m, 2H); MS (ESI+) m/z: 163 [M + H]+.
References
[1] Patent: WO2013/127266, 2013, A1. Location in patent: Page/Page column 130
[2] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 81; 82
[3] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 59; 60
[4] Patent: WO2013/130943, 2013, A1. Location in patent: Paragraph 0181
imidazo[1,2-a]pyridine-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
imidazo[1,2-a]pyridine-6-carboxylic acid Suppliers
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- tech@alfa.com
- Country
- India
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- 6905
- Advantage
- 58
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- sales@ajchem.in
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View Lastest Price from imidazo[1,2-a]pyridine-6-carboxylic acid manufacturers
- Product
- Imidazo[1,2-a]pyridine-6-carboxylic acid 139022-25-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.5%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID 139022-25-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID 139022-25-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05