ChemicalBook > CAS DataBase List > 2-QUINOLINYLMETHANOL

2-QUINOLINYLMETHANOL

Product Name: 2-QUINOLINYLMETHANOL
CAS No.: 1780-17-2
Chemical Name: 2-QUINOLINYLMETHANOL
Synonyms: QUINOLIN-2-YLMETHANOL;α-Quinaldinol;2-QUINOLINONE;2-quinolylmethanol;RARECHEM AK ML 0556;2-QUINOLINEMETHANOL;2-QUINOLINYLMETHANOL;2-Quinolineylmethanol;2-HYDROXYMETHYLQUINOLINE;4-Hydroxymethyl-2-pyrrolidinone
CBNumber: CB4461872
Molecular Formula: C10H9NO
Formula Weight: 159.18
MOL File: 1780-17-2.mol

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2-QUINOLINYLMETHANOL Property

Melting point:: 64 °C
Boiling point:: 205 °C(Press: 15 Torr)
Density: 1.218±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 14.29±0.10(Predicted)
color: White to Off-White
CAS DataBase Reference: 1780-17-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38-41-37/38
Safety Statements: 26-36/37/39-39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933491090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC

Product number: Q990150
Product name: 2-Quinolinylmethanol
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR23074
Product name: 2-(Hydroxymethyl)quinoline
Purity: 97%
Packaging: 250mg
Price: $48
Updated: 2021/12/16

AK Scientific

Product number: KMA0114
Product name: 2-Quinolinylmethanol
Packaging: 250mg
Price: $49.5
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-1-T3
Product name: 2-(Hydroxymethyl)quinoline
Packaging: 250mg
Price: $53
Updated: 2021/12/16

AK Scientific

Product number: KMA0114
Product name: 2-Quinolinylmethanol
Packaging: 1g
Price: $123.2
Updated: 2021/12/16

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2-QUINOLINYLMETHANOL Chemical Properties,Usage,Production

Uses

Intermediate in the preparation of aminopiperidines and related compounds as MCH receptor modulators useful in the treatment of metabolic, feeding and sexual disorders in humans.

Synthesis

19575-07-6

1780-17-2

General procedure for the synthesis of 2-hydroxymethylquinoline from methyl quinoline-2-carboxylate: a tetrahydrofuran (THF, 30 mL) solution of methyl quinoline-2-carboxylate (5 g, 26.8 mmol) was slowly added to a tetrahydrofuran (THF, 20 mL) solution containing sodium borohydride (NaBH4, 710 mg, 18.8 mmol) at room temperature. The reaction mixture was stirred at 35 °C for 30 min. Subsequently, methanol (2.5 mL), warm water (30 mL) and ethyl acetate (20 mL) were added sequentially at the same temperature. The organic layer was separated and washed with deionized water (2 x 30 mL). The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/methylcyclohexane=60/40) to give a white solid product in 73% yield. The melting point of the product was 135 °C (decomposition). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) showed: δ 4.68 (1H, s, OH), 4.95 (2H, s, CH2), 7.31 (1H, m, aromatic CH), 7.55 (1H, m, aromatic CH), 7.71 (1H, m, aromatic CH), 7.81 (1H, m, aromatic CH), 8.10 (2H , m, aromatic CH). The nuclear magnetic resonance carbon spectrum (13C NMR, 75 MHz, CDCl3) showed: δ 64.25, 118.43, 126.35, 127.55, 127.69, 128.57, 129.81, 136.86, 146.72, 159.19. Calculated values for elemental analysis (C10H9NO): C, 75.45; H, 5.70 Measured values (C10H9NO): C, 75.45; H, 5.70; N, 8.80; measured values: C, 75.13; H, 5.56; N, 8.75.

References

[1] Organic Letters, 2005, vol. 7, # 17, p. 3609 - 3612
[2] Tetrahedron Letters, 2012, vol. 53, # 35, p. 4747 - 4750
[3] Tetrahedron, 2013, vol. 69, # 44, p. 9322 - 9328
[4] Tetrahedron Asymmetry, 2009, vol. 20, # 14, p. 1672 - 1682
[5] Journal of Organic Chemistry, 1953, vol. 18, p. 55,56

2-QUINOLINYLMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-QUINOLINYLMETHANOL manufacturers

Career Henan Chemical Co

Product: 2-QUINOLINYLMETHANOL 1780-17-2
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-30

Nanjing jinheyou Trading Co., Ltd.

Product: 2-QUINOLINYLMETHANOL 1780-17-2
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-19

1780-17-2, 2-QUINOLINYLMETHANOLRelated Search:

C-Quinolin-2-yl-methylamine dihydrochloride 4-Quinoline-carboxamide 2-Quinolinecarboxaldehyde 4-CYANOQUINOLINE 7-AMinoquinoline Hydrochloride 3-Quinolinecarboxaldehyde 3-Quinolinecarboxylic acid 6-Quinolinecarbaldehyde Quinoline-6-boronic acid QUINOLINE-6-SULFONYL CHLORIDE QUINAZOLIN-4-YLAMINE 8-Quinolinesulfonyl chloride methyl quinoline-3-carboxylate QUINOLIN-7-YLBORONIC ACID Quinoline-5-boronic acid Quinoline-5-carboxylic acid 2-QUINOLINYLMETHANOL 6-QUINOLINYLMETHANOL

RARECHEM AK ML 0556

QUINOLIN-2-YLMETHANOL

2-QUINOLINEMETHANOL

2-QUINOLINYLMETHANOL

2-HYDROXYMETHYLQUINOLINE

2-quinolylmethanol

2-QUINOLINONE

2-Quinolineylmethanol

α-Quinaldinol

(Quinolin-2-yl)methanol, 2-(Hydroxymethyl)-1-azanaphthalene

4-(quinolin-2-yl-methoxy)phenyl cyclohexyl ketone

4-Hydroxymethyl-2-pyrrolidinone

1780-17-2

Quinoline

Quinoline series

Heterocycles