2-Amino-6-bromopyridine
- Product Name
- 2-Amino-6-bromopyridine
- CAS No.
- 19798-81-3
- Chemical Name
- 2-Amino-6-bromopyridine
- Synonyms
- 6-Bromopyridin-2-amine;2-AMINO-6-BROMO-PHENOL; 19798-81-3;Aminobromopyridine;2-AMINO-6-BROMPYRIDINE;2A6BP;6-BROMO-2-PYRIDINAMINE;2-Bromo-6-Aminopyridine;6-BROMO-2-AMINOPYRIDINE;2-PyridinaMine,6-broMo-
- CBNumber
- CB4471572
- Molecular Formula
- C5H5BrN2
- Formula Weight
- 173.01
- MOL File
- 19798-81-3.mol
2-Amino-6-bromopyridine Property
- Melting point:
- 88-91 °C (lit.)
- Boiling point:
- 273.0±20.0 °C(Predicted)
- Density
- 1.710±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Very Slightly)
- pka
- 2.73±0.24(Predicted)
- form
- Powder
- color
- Slightly yellow to light brown
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C5H5BrN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)
- InChIKey
- BKLJUYPLUWUEOQ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Br)=CC=C1
- CAS DataBase Reference
- 19798-81-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 521744
- Product name
- 2-Amino-6-bromopyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $45.9
- Updated
- 2025/07/31
- Product number
- 521744
- Product name
- 2-Amino-6-bromopyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- A1529
- Product name
- 2-Amino-6-bromopyridine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- A1529
- Product name
- 2-Amino-6-bromopyridine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $166
- Updated
- 2025/07/31
- Product number
- A601945
- Product name
- 2-Amino-6-bromopyridine
- Packaging
- 10g
- Price
- $150
- Updated
- 2021/12/16
2-Amino-6-bromopyridine Chemical Properties,Usage,Production
Chemical Properties
Slightly yellow to light brown powder
Uses
Employed in an efficient one-pot synthesis of 7-azaindoles. Used in the synthesis of anti-HIV agents.
Uses
2-Amino-6-bromopyridine is a disubstituted pyridine used as a building block in the preparation of nitrogen containing bicyclic and polycylic compounds.
Application
2-Amino-6-bromopyridine is an important raw material for the synthesis of:
2-amino-6-diethylaminopyridine
2,6-di-(methylamino)-pyridine
3-(6-bromopyridin-2-yl)-2-(2,6-difluorophenyl)-1,3-thiazolidin-4-one
N-(6-bromopyridin-2-yl)dodecylamide
2-bromo-6-iodopyridine
Employed in an efficient one-pot synthesis of 7-azaindoles.
Used in the synthesis of anti-HIV agents.
General Description
2-Amino- 6-bromopyridine has been synthesized from epichlorohydrin.
Synthesis
626-05-1
141-86-6
19798-81-3
14.1 Preparation of 6-bromo-2-aminopyridine In a steel autoclave equipped with a glass liner, 10.00 g of 2,6-dibromopyridine (42.2 mmol) was suspended in 50 mL of concentrated ammonia. The autoclave was sealed and heated to 190°C using a heating jacket and maintained for 6 hours (pressure was raised to about 25 bar). After the autoclave was cooled and depressurized, the reaction mixture was mixed with 100 mL of ethyl acetate for phase separation. The aqueous phase was extracted twice with ethyl acetate, 100 mL each. the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in 250 mL of a solvent mixture of cyclohexane/ethyl acetate (1:1, v/v) to remove the by-product 2,6-diaminopyridine. Subsequently, the solution was filtered through a short silica gel column (5 x 20 cm) and washed again with 250 mL of cyclohexane/ethyl acetate (1:1, v/v) mixed solvent. After removal of the solvent under reduced pressure, the residue was sublimated at 90°C and 10-1 mbar to give 6.49 g (37.5 mmol, 88.9% yield) of 6-bromo-2-aminopyridine as a white solid.
References
[1] Patent: US2004/199024, 2004, A1. Location in patent: Page 17
[2] Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 381,386, 949
[3] Chemical Communications, 2010, vol. 46, # 6, p. 925 - 927
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View Lastest Price from 2-Amino-6-bromopyridine manufacturers
- Product
- 2-Amino-6-bromopyridine 19798-81-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- L-tBuO-Pal-Glu(OSu)-OtBu 19798-81-3
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-14
- Product
- 2-Amino-6-bromopyridine 19798-81-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08