4-HYDROXY PROPRANOLOL HCL
- Product Name
- 4-HYDROXY PROPRANOLOL HCL
- CAS No.
- 14133-90-5
- Chemical Name
- 4-HYDROXY PROPRANOLOL HCL
- Synonyms
- Propranolol Impurity 10;4-HYDROXY PROPRANOLOL HCL;rac-4-Hydroxy Propranolol HCl;Propranolol 4-Hydroxy Impurity;4-Hydroxy Propranolol HCl (Rac);(±)-4-Hydroxypropranolol-d7 HCl;4-HYDROXYPROPRANOLOL HYDROCHLORIDE;(R)-4-Hydroxy Propranolol Hydrochloride;(S)-4-Hydroxy Propranolol Hydrochloride;rac-4-Hydroxy Propranolol Hydrochloride
- CBNumber
- CB4752444
- Molecular Formula
- C16H22ClNO3
- Formula Weight
- 311.8
- MOL File
- 14133-90-5.mol
4-HYDROXY PROPRANOLOL HCL Property
- Melting point:
- 156-158°C
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale Red to Black
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 18630
- Product name
- (±)-4-hydroxy Propranolol (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18630
- Product name
- (±)-4-hydroxy Propranolol (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $202
- Updated
- 2024/03/01
- Product number
- 18630
- Product name
- (±)-4-hydroxy Propranolol (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $363
- Updated
- 2024/03/01
- Product number
- H952545
- Product name
- rac-4-HydroxyPropranololHydrochloride
- Packaging
- 5mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- H952545
- Product name
- rac-4-HydroxyPropranololHydrochloride
- Packaging
- 50mg
- Price
- $1455
- Updated
- 2021/12/16
4-HYDROXY PROPRANOLOL HCL Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
The main metabolite of (R)-Propranolol
Uses
The main metabolite of (S)-Propranolol
Uses
A metabolite of Propranolol.
Biological Activity
(±)-4-hydroxy propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ars, β2-ars). also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ars, expressed in cardiac myocytes, mediate an increase in contractility by gs-dependent coupling to adenylyl cyclase.
in vitro
compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. when pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μm, the degrees of protection were increased against the glutathione loss in the endothelial cells. additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].
in vivo
rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. the response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].
IC 50
1.1 μm: inhibits lipid peroxidation in endothelial cells.
References
[1]. mak, i. potent antioxidant properties of 4-hydroxyl-propranolol. journal of pharmacology and experimental therapeutics. 2003; 308(1): 85-90.
[2]. fitzgerald, j., & o'donnell, s. pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. british journal of pharmacology. 1971; 43(1): 222-235.