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4-HYDROXY PROPRANOLOL HCL

Product Name
4-HYDROXY PROPRANOLOL HCL
CAS No.
14133-90-5
Chemical Name
4-HYDROXY PROPRANOLOL HCL
Synonyms
Propranolol Impurity 10;4-HYDROXY PROPRANOLOL HCL;rac-4-Hydroxy Propranolol HCl;Propranolol 4-Hydroxy Impurity;4-Hydroxy Propranolol HCl (Rac);(±)-4-Hydroxypropranolol-d7 HCl;4-HYDROXYPROPRANOLOL HYDROCHLORIDE;Propranolol Impurity 21(Hydrochloride);(R)-4-Hydroxy Propranolol Hydrochloride;(S)-4-Hydroxy Propranolol Hydrochloride
CBNumber
CB4752444
Molecular Formula
C16H21NO3.ClH
Formula Weight
311.8
MOL File
14133-90-5.mol
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4-HYDROXY PROPRANOLOL HCL Property

Melting point:
156-158°C
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Red to Black
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18630
Product name
(±)-4-hydroxy Propranolol (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18630
Product name
(±)-4-hydroxy Propranolol (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
18630
Product name
(±)-4-hydroxy Propranolol (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$363
Updated
2024/03/01
TRC
Product number
H952545
Product name
rac-4-HydroxyPropranololHydrochloride
Packaging
5mg
Price
$185
Updated
2021/12/16
TRC
Product number
H952545
Product name
rac-4-HydroxyPropranololHydrochloride
Packaging
50mg
Price
$1455
Updated
2021/12/16
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4-HYDROXY PROPRANOLOL HCL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

The main metabolite of (R)-Propranolol

Uses

The main metabolite of (S)-Propranolol

Uses

A metabolite of Propranolol.

Biological Activity

(±)-4-hydroxy propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ars, β2-ars). also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ars, expressed in cardiac myocytes, mediate an increase in contractility by gs-dependent coupling to adenylyl cyclase.

in vitro

compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. when pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μm, the degrees of protection were increased against the glutathione loss in the endothelial cells. additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].

in vivo

rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. the response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].

IC 50

1.1 μm: inhibits lipid peroxidation in endothelial cells.

References

[1]. mak, i. potent antioxidant properties of 4-hydroxyl-propranolol. journal of pharmacology and experimental therapeutics. 2003; 308(1): 85-90.
[2]. fitzgerald, j., & o'donnell, s. pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. british journal of pharmacology. 1971; 43(1): 222-235.

4-HYDROXY PROPRANOLOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXY PROPRANOLOL HCL Suppliers

Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58

14133-90-5, 4-HYDROXY PROPRANOLOL HCLRelated Search:


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