4-HYDROXY PROPRANOLOL HCL

Product Name: 4-HYDROXY PROPRANOLOL HCL
CAS No.: 14133-90-5
Chemical Name: 4-HYDROXY PROPRANOLOL HCL
Synonyms: Propranolol Impurity 10;4-HYDROXY PROPRANOLOL HCL;rac-4-Hydroxy Propranolol HCl;Propranolol 4-Hydroxy Impurity;4-Hydroxy Propranolol HCl (Rac);(±)-4-Hydroxypropranolol-d7 HCl;4-HYDROXYPROPRANOLOL HYDROCHLORIDE;Propranolol Impurity 21(Hydrochloride);(R)-4-Hydroxy Propranolol Hydrochloride;(S)-4-Hydroxy Propranolol Hydrochloride
CBNumber: CB4752444
Molecular Formula: C16H21NO3.ClH
Formula Weight: 311.8
MOL File: 14133-90-5.mol

More

Less

4-HYDROXY PROPRANOLOL HCL Property

Melting point:: 156-158°C
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Pale Red to Black
Stability:: Hygroscopic

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18630
Product name: (±)-4-hydroxy Propranolol (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18630
Product name: (±)-4-hydroxy Propranolol (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 18630
Product name: (±)-4-hydroxy Propranolol (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $363
Updated: 2024/03/01

TRC

Product number: H952545
Product name: rac-4-HydroxyPropranololHydrochloride
Packaging: 5mg
Price: $185
Updated: 2021/12/16

TRC

Product number: H952545
Product name: rac-4-HydroxyPropranololHydrochloride
Packaging: 50mg
Price: $1455
Updated: 2021/12/16

More

Less

4-HYDROXY PROPRANOLOL HCL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

The main metabolite of (R)-Propranolol

Uses

The main metabolite of (S)-Propranolol

Uses

A metabolite of Propranolol.

Biological Activity

(±)-4-hydroxy propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ars, β2-ars). also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ars, expressed in cardiac myocytes, mediate an increase in contractility by gs-dependent coupling to adenylyl cyclase.

in vitro

compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. when pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μm, the degrees of protection were increased against the glutathione loss in the endothelial cells. additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].

in vivo

rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. the response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].

IC 50

1.1 μm: inhibits lipid peroxidation in endothelial cells.

References

[1]. mak, i. potent antioxidant properties of 4-hydroxyl-propranolol. journal of pharmacology and experimental therapeutics. 2003; 308(1): 85-90.
[2]. fitzgerald, j., & o'donnell, s. pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. british journal of pharmacology. 1971; 43(1): 222-235.

4-HYDROXY PROPRANOLOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-HYDROXY PROPRANOLOL HCL Suppliers

Canada 4 China 36 India 4 Japan 1 United States 13 Global 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Artis Biotech Co. Ltd.

Tel: 0575-18780151478 18582380095
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 2966
Advantage: 58

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2988
Advantage: 58

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@qq.com
Country: China
ProdList: 8705
Advantage: 55

14133-90-5, 4-HYDROXY PROPRANOLOL HCLRelated Search:

Methylamine hydrochloride Betaine hydrochloride Dimethylamine hydrochloride Propranolol hydrochloride

4-HYDROXY PROPRANOLOL HCL

4-HYDROXYPROPRANOLOL HYDROCHLORIDE

(R)-4-Hydroxy Propranolol Hydrochloride

4-[(2R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol Hydrochloride

(S)-4-Hydroxy Propranolol Hydrochloride

4-[(2S)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol Hydrochloride

rac-4-Hydroxy Propranolol Hydrochloride

(±)-4-Hydroxypropranolol-d7 HCl

1-[(4-Hydroxy-1-naphthyl)oxy]-3-(isopropylamino)- 2-propanol hydrochloride

4-Hydroxy Propranolol HCl (Rac)

rac-4-Hydroxy Propranolol HCl

Propranolol 4-Hydroxy Impurity

4-Hydroxy propranolol HydrochlorideQ: What is 4-Hydroxy propranolol Hydrochloride Q: What is the CAS Number of 4-Hydroxy propranolol Hydrochloride Q: What is the storage condition of 4-Hydroxy propranolol Hydrochloride

Propranolol Impurity 10

1-Naphthalenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, hydrochloride (1:1)

Propranolol Impurity 21(Hydrochloride)

14133-90-5

Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals