4-HYDROXY PROPRANOLOL HCL

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4-HYDROXY PROPRANOLOL HCL

Product Name: 4-HYDROXY PROPRANOLOL HCL
CAS No.: 14133-90-5
Chemical Name: 4-HYDROXY PROPRANOLOL HCL
Synonyms: Propranolol Impurity 10;4-HYDROXY PROPRANOLOL HCL;rac-4-Hydroxy Propranolol HCl;Propranolol 4-Hydroxy Impurity;4-Hydroxy Propranolol HCl (Rac);(±)-4-Hydroxypropranolol-d7 HCl;4-HYDROXYPROPRANOLOL HYDROCHLORIDE;Propranolol Impurity 21(Hydrochloride);(R)-4-Hydroxy Propranolol Hydrochloride;(S)-4-Hydroxy Propranolol Hydrochloride
CBNumber: CB4752444
Molecular Formula: C16H21NO3.ClH
Formula Weight: 311.8
MOL File: 14133-90-5.mol

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4-HYDROXY PROPRANOLOL HCL Property

Melting point:: 156-158°C
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Pale Red to Black
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18630
Product name: (±)-4-hydroxy Propranolol (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18630
Product name: (±)-4-hydroxy Propranolol (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 18630
Product name: (±)-4-hydroxy Propranolol (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $363
Updated: 2024/03/01

TRC

Product number: H952545
Product name: rac-4-HydroxyPropranololHydrochloride
Packaging: 5mg
Price: $185
Updated: 2021/12/16

TRC

Product number: H952545
Product name: rac-4-HydroxyPropranololHydrochloride
Packaging: 50mg
Price: $1455
Updated: 2021/12/16

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4-HYDROXY PROPRANOLOL HCL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

The main metabolite of (R)-Propranolol

Uses

The main metabolite of (S)-Propranolol

Uses

A metabolite of Propranolol.

Biological Activity

(±)-4-hydroxy propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ars, β2-ars). also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ars, expressed in cardiac myocytes, mediate an increase in contractility by gs-dependent coupling to adenylyl cyclase.

in vitro

compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. when pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μm, the degrees of protection were increased against the glutathione loss in the endothelial cells. additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].

in vivo

rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. the response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].

IC 50

1.1 μm: inhibits lipid peroxidation in endothelial cells.

References

[1]. mak, i. potent antioxidant properties of 4-hydroxyl-propranolol. journal of pharmacology and experimental therapeutics. 2003; 308(1): 85-90.
[2]. fitzgerald, j., & o'donnell, s. pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. british journal of pharmacology. 1971; 43(1): 222-235.

4-HYDROXY PROPRANOLOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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14133-90-5, 4-HYDROXY PROPRANOLOL HCLRelated Search:

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4-HYDROXY PROPRANOLOL HCL

4-HYDROXYPROPRANOLOL HYDROCHLORIDE

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4-Hydroxy propranolol HydrochlorideQ: What is 4-Hydroxy propranolol Hydrochloride Q: What is the CAS Number of 4-Hydroxy propranolol Hydrochloride Q: What is the storage condition of 4-Hydroxy propranolol Hydrochloride

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14133-90-5

Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

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