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ETAZOLATE

Product Name
ETAZOLATE
CAS No.
35838-58-5
Chemical Name
ETAZOLATE
Synonyms
Nsc163611;Etazolate hydrochloride solid;Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo[3,4-B]pyridine-5-carboxylate monohydrochloride;1-ethyl-4-[(1-methylethylidene)hydrazino]1h-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;1H-Pyrazolo[3,4-B]pyridine-5-carboxylic acid, 1-ethyl-4-[(1-methylethylidene)hydrazino]-, ethyl ester, monohydrochloride;SQ20009, 1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride
CBNumber
CB4972600
Molecular Formula
C14H18N5O2HCl
Formula Weight
0
MOL File
35838-58-5.mol
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ETAZOLATE Property

Melting point:
193-194 °C
storage temp. 
room temp
solubility 
H2O: >20mg/mL (Solutions should be freshly prepared.)
form 
solid
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E889255
Product name
Etazolate hydrochloride
Packaging
10mg
Price
$575
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008346
Product name
ETAZOLATE HYDROCHLORIDE
Purity
95.00%
Packaging
25MG
Price
$1024.78
Updated
2021/12/16
ApexBio Technology
Product number
B6304
Product name
Etazolate hydrochloride
Packaging
10mM(in 1mL H2O)
Price
$50
Updated
2021/12/16
ApexBio Technology
Product number
B6304
Product name
Etazolate hydrochloride
Packaging
10mg
Price
$99
Updated
2021/12/16
ApexBio Technology
Product number
B6304
Product name
Etazolate hydrochloride
Packaging
50mg
Price
$419
Updated
2021/12/16
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ETAZOLATE Chemical Properties,Usage,Production

Uses

Antipsychotic.

Uses

Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.

Biological Activity

etazolate hydrochloride is a pde-4 inhibitor and selective gaba-a receptor modulator [3].pde-4 modulates the release of inflammatory mediators through camp-dependent and -independent mechanisms. selective targeting pde-4 is a novel therapeutic approach in the treatment of inflammation-associated respiratory diseases, such as asthma and copd (chronic obstructive pulmonary disease) [1].in rat neuronal cortical cells, etazolate hydrochloride (0.2 μm) induced sappα through the stimulation of the α-secretase pathway, and exerted a neuroprotective effect against aβ which was associated with sappα induction via the gaba-a receptor [2].in 159 alzheimer’s disease patients, etazolate hydrochloride in combination with one achei (acetycholinesterase inhibitor) was shown to be safe and generally well tolerated in the phase iia study over a 3-month treatment period [3].

Biochem/physiol Actions

Selective inhibitor of cAMP-specific phosphodiesterase.

References

[1] dastidar s g, rajagopal d, ray a. therapeutic benefit of pde4 inhibitors in inflammatory diseases.[j]. current opinion in investigational drugs, 2007, 8(5):364-72.
[2] marcade m, bourdin j, loiseau n, et al. etazolate, a neuroprotective drug linking gaba(a) receptor pharmacology to amyloid precursor protein processing.[j]. journal of neurochemistry, 2008, 106(1):392-404.
[3] vellas b; sol o; snyder pj; ousset pj; haddad r; maurin m; lemarié jc; désiré l; pando mp; eht0202/002 study group. eht0202 in alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study.[j]. current alzheimer research, 2011, 8(2):203-12.

ETAZOLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETAZOLATE Suppliers

Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

35838-58-5, ETAZOLATERelated Search:


  • 1-ethyl-4-[(1-methylethylidene)hydrazino]1h-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride
  • SQ20009, 1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride
  • 1H-Pyrazolo[3,4-B]pyridine-5-carboxylic acid, 1-ethyl-4-[(1-methylethylidene)hydrazino]-, ethyl ester, monohydrochloride
  • Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo[3,4-B]pyridine-5-carboxylate monohydrochloride
  • Nsc163611
  • Etazolate hydrochloride solid
  • 35838-58-5
  • C14H18N5O2HCl