ChemicalBook > CAS DataBase List > Methyl 3-amino-2-thiophenecarboxylate

Methyl 3-amino-2-thiophenecarboxylate

Product Name
Methyl 3-amino-2-thiophenecarboxylate
CAS No.
22288-78-4
Chemical Name
Methyl 3-amino-2-thiophenecarboxylate
Synonyms
METHYL 3-AMINOTHIOPHENE-2-CARBOXYLATE;M3AT2C;AKOS 92421;ina-5545-2;Methyl3-am;AKOS B020093;Methyl 3-amino-2-;3-Amino-2-thenoate;RARECHEM AM UC 0123;Methyl 3-amino-2-thi
CBNumber
CB5123399
Molecular Formula
C6H7NO2S
Formula Weight
157.19
MOL File
22288-78-4.mol
More
Less

Methyl 3-amino-2-thiophenecarboxylate Property

Melting point:
62-64 °C (lit.)
Boiling point:
100-102 °C/0.1 mmHg (lit.)
Density 
1.274 (estimate)
refractive index 
1.5500 (estimate)
Flash point:
100-102°C/0.1mm
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Fine Crystalline Powder
pka
1.86±0.10(Predicted)
color 
Beige to beige-brown
Water Solubility 
Slightly soluble in water.
BRN 
1365614
InChI
InChI=1S/C6H7NO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,7H2,1H3
InChIKey
TWEQNZZOOFKOER-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)SC=CC=1N
CAS DataBase Reference
22288-78-4(CAS DataBase Reference)
EPA Substance Registry System
2-Thiophenecarboxylic acid, 3-amino-, methyl ester (22288-78-4)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36/37/39-22
WGK Germany 
3
RTECS 
XM8347500
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
232904
Product name
Methyl 3-amino-2-thiophenecarboxylate
Purity
99%
Packaging
10g
Price
$43.15
Updated
2025/07/31
Sigma-Aldrich
Product number
232904
Product name
Methyl 3-amino-2-thiophenecarboxylate
Purity
99%
Packaging
50g
Price
$208.05
Updated
2025/07/31
TCI Chemical
Product number
A1039
Product name
Methyl 3-Amino-2-thiophenecarboxylate
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
A1039
Product name
Methyl 3-Amino-2-thiophenecarboxylate
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$157
Updated
2025/07/31
TRC
Product number
A612075
Product name
3-Amino-2-methoxycarbonylthiophene
Packaging
100g
Price
$360
Updated
2021/12/16
More
Less

Methyl 3-amino-2-thiophenecarboxylate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Methyl 3-amino-2-thiophenecarboxylate was used in:

  • the synthesis of 4-nitro and 4-aminothienyl ureas
  • total synthesis of quinazolinocarboline alkaloids
  • preparation of thienopyrimidinone analogs

Uses

Methyl 3-amino-2-thiophenecarboxylate is the starting material for synthesising Belvarafenib. Belvarafenib is a small-molecule RAF dimer (type II) inhibitor with potential antitumour activity.

General Description

Methyl 3-amino-2-thiophenecarboxylate reacts with hydrazonoyl chlorides in the presence of triethylamine to yield corresponding N-arylamidrazones.

Methyl 3-amino-2-thiophenecarboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate 1.3-Dichloropropene Sodium methoxide solution Acrylonitrile

Preparation Products

2,4-DICHLOROTHIENO[3,2-D]PYRIMIDINE 3-(Acetylamino)thiophene-2-carboxylic acid 3-(1H-PYRROL-1-YL)THIOPHENE-2-CARBOXYLIC ACID 2,4-Dichlorothieno[3,2-d]pyrimidine Methyl 3-aminosulfonylthiophene-2-carboxylate METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE 3-CHLOROTHIOPHENE-2-CARBOXAMIDE METHYL 3-[(2-BROMOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE 2,4-DIHYDROXYTHIENO[3,2-D]PYRIMIDINE
More
Less

Methyl 3-amino-2-thiophenecarboxylate Suppliers

Americas 1 Austria 1 Belgium 4 Canada 1 China 347 Europe 3 France 2 Germany 10 India 22 Japan 3 Russia 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 21 United States 58 Global 478
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Exim-Indis, Inc. (part of Exim Corporation and Indis N.V.)
Tel
--
Fax
--
Email
info@exim-indis.com
Country
United States
ProdList
440
Advantage
58
Wilshire Technologies
Tel
--
Fax
--
Country
United States
ProdList
428
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
ChemArch LLC
Tel
--
Fax
--
Country
United States
ProdList
15
Advantage
58
Natland International Corporation
Tel
--
Fax
--
Email
info@natland.com
Country
United States
ProdList
156
Advantage
50
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
RIA International LLC
Tel
--
Fax
--
Email
marketing@riausa.net
Country
United States
ProdList
1324
Advantage
50
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Frontier Scientific Services, Inc.
Tel
--
Fax
--
Email
customerservice@frontierssi.com
Country
United States
ProdList
1575
Advantage
0
Lianyungang Ziyan Chemical Co., Ltd.
Tel
--
Fax
--
Email
ziyanchem@gmail.com
Country
United States
ProdList
360
Advantage
0
Anisyn, Inc.
Tel
--
Fax
--
Email
sales@anisyn.com
Country
United States
ProdList
863
Advantage
0
Accela ChemBio Inc.
Tel
--
Fax
--
Email
info@accelachem.com
Country
United States
ProdList
1054
Advantage
50
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
HDH Pharma, Inc.
Tel
--
Fax
--
Email
catalog@hdhpharma.com
Country
United States
ProdList
6248
Advantage
62
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Bio-Vin Research Laboratories
Tel
--
Fax
--
Email
sales@biovinresearch.com
Country
United States
ProdList
6210
Advantage
64
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
More
Less

View Lastest Price from Methyl 3-amino-2-thiophenecarboxylate manufacturers

Shandong Vital Biotechnology Co., Ltd.
Product
Methyl3-amino-2-thiophenecarboxylate 22288-78-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100tons
Release date
2025-11-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methyl 3-amino-2-thiophenecarboxylate 22288-78-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-25
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Methyl 3-amino-2-thiophene carboxylate 22288-78-4
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-26

22288-78-4, Methyl 3-amino-2-thiophenecarboxylate Related Search:

METSULFURON METHYL 2-Thiophenecarboxylic acid Methylparaben Kresoxim-methyl Methyl anthranilate Methyl benzoate Methyl acrylate Bensulfuron methyl Methyl 2-iodobenzoate Methyl formate Trimethoxymethane Methyl acetate RESMETHRIN 3-AMINOTHIOPHENE methyl 3-bromo-6-methylpicolinate Methyl 3-amino-2-pyrazinecarboxylate Thiophanate-methyl Methyl

  • AMino-2-thiophenecarboxylate
  • AMino thiophene - 2-3 - carboxylic acid Methyl ester
  • Methyl3-aMino-2-thiophenecarbo
  • RARECHEM AM UC 0123
  • 3-amino-2-thiophenecarboxylicacimethylester
  • ina-5545-2
  • Methyl3-amino-2-thenoate
  • 3-AMINO-2-METHOXYCARBONYLTHIOPHENE
  • 3-AMINO-2-THIOPHENECARBOXYLIC ACID METHYL ESTER
  • 3-AMINOTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
  • AKOS 92421
  • AKOS B020093
  • ASINEX-REAG BAS 05504796
  • LABOTEST-BB LT00112337
  • M3AT2C
  • METHYL 3-AMINO-2-THIOPHENECARBOXYLATE
  • METHYL-3-AMINO-2-THIOPHENE FORMATE
  • METHYL 3-AMINOTHIOPHENE-2-CARBOXYLATE
  • METHYL 3-AMINO-2-THIOPHENECARBOXYLATE, 9 9%
  • Methyl 3-aminothiophene-2-carboxylate, 98+%
  • 3-AMINO-2-THIOPHENE METHYLFORMATE
  • Name: 3-Aminothiophene-2-carboxylic acid methyl ester
  • Methyl-3-Aminothiophene-2-Carb
  • 3-amino-2-thiophenecarboxylate
  • 3-aminothiophene-2-carboxyL
  • Methyl 3-amino-2-
  • 3-Aminothiophen-2-carboxylic acid methyl ester
  • Methyl 3-amino-2-thiophenecarboxylate ,98%
  • Methyl3-am
  • Methy1-3-amino-2-thiophene carboxylate
  • 3-Amino-2-thenoate
  • 3-aminothiophene-2-carboxylate
  • Methyl 3-aminothiophene-2-carboxylate ,95%
  • Methyl 3-amino-2-thi
  • Methyl 3-aMino-2-thiophenecarboxylate, 99% 10GR
  • Methyl 3-aMino-2-thiophenecarboxylate, 99% 50GR
  • 2-Methoxycarbonyl-3-aMino-thiophene
  • 3-aMino-2-carboMethoxythiophene
  • Methyl 3-Amino-2-thiophenecarboxylate &gt
  • 3-amino-2-carboxylate methyl thiophene
  • Methyl 3-amino-2-thiophenoate
  • Methyl 3-amino-2-thiophenecarboxylate USP/EP/BP
  • Methyl 3-aminothiophene-2-carboxylateQ: What is Methyl 3-aminothiophene-2-carboxylate Q: What is the CAS Number of Methyl 3-aminothiophene-2-carboxylate Q: What is the storage condition of Methyl 3-aminothiophene-2-carboxylate Q: What are the applications of Methyl 3-aminothiophene-2-carboxylate
  • Methyl-3-amino2-thiopene carboxylate
  • Methyl-3-aminothiophen-3-carboxylate
  • 22288-78-4
  • 22288-74-4
  • C6H7NO2S
  • Heterocyclic Building Blocks
  • Thiophenes
  • Building Blocks
  • API intermediates
  • Thiophenes & Benzothiophenes
  • Pharmaceutical intermediate
  • Sulphur Derivatives
  • INTERMEDIATESOFTENOXICAM
  • Esters
  • Thiophenes & Benzothiophenes