ChemicalBook > CAS DataBase List > 2-Iodoaniline

2-Iodoaniline

Product Name
2-Iodoaniline
CAS No.
615-43-0
Chemical Name
2-Iodoaniline
Synonyms
O-IODOANILINE;2-lodoaniline;Aniline o-iodine;2-IodoaniL;2-Iodylamine;2-IODOANILINE;Aniline, 2-iodo-;Aniline, o-iodo-;2-Iodoaniline>2-iodo-benzenamin
CBNumber
CB5125267
Molecular Formula
C6H6IN
Formula Weight
219.02
MOL File
615-43-0.mol
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2-Iodoaniline Property

Melting point:
55-58 °C (lit.)
Boiling point:
262.0±23.0 °C(Predicted)
Density 
1.8155 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Chloroform, DCM, Ethyl Acetate, Toluene
form 
Crystalline Needles
pka
2.6(at 25℃)
color 
Yellow to brown
Water Solubility 
Insoluble in water.
Sensitive 
Light Sensitive
BRN 
2204899
InChIKey
UBPDKIDWEADHPP-UHFFFAOYSA-N
CAS DataBase Reference
615-43-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2-iodo-(615-43-0)
EPA Substance Registry System
o-Iodoaniline (615-43-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-37/38-36/37/38
Safety Statements 
36/37-36/37/39-26-36
RIDADR 
2811
WGK Germany 
3
F 
8
Hazard Note 
Irritant
TSCA 
T
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29214210
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I7004
Product name
2-Iodoaniline
Purity
98%
Packaging
5g
Price
$50.2
Updated
2024/03/01
Sigma-Aldrich
Product number
I7004
Product name
2-Iodoaniline
Purity
98%
Packaging
25g
Price
$123
Updated
2024/03/01
TCI Chemical
Product number
I0046
Product name
2-Iodoaniline
Packaging
5G
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
I0046
Product name
2-Iodoaniline
Packaging
25G
Price
$101
Updated
2024/03/01
Alfa Aesar
Product number
A13059
Product name
2-Iodoaniline, 98+%
Packaging
5g
Price
$37.65
Updated
2024/03/01
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2-Iodoaniline Chemical Properties,Usage,Production

Chemical Properties

YELLOW TO BROWN CRYSTALLINE NEEDLES

Uses

2-Iodoaniline is used as an intermediate in organic synthesis.

Uses

2-Iodobenzenamine is an synthetic intermediate for the synthesis of complex organic compounds and pharmaceuticals.

Preparation

2-iodoaniline and its derivatives are commonly used for the preparation of indole-based anticancer drugs, which have high market value, and further synthesis can lead to high-end synthetic intermediates with complex structures.
Take a reaction tube, add 50mg of sodium azide, 75mg of 1-(2-iodophenyl)ethanol, 300uL of trifluoroacetic acid, 150uL of methanesulfonic acid and 1.0mL of hexane, and stir for 24 hours at 40℃. After the reaction, 10 mL of sodium hydroxide solution was added to quench the reaction. The organic phase was washed with 5 mL of brine, and the organic phase was combined and separated by column chromatography to obtain 58.4 mg of 2-iodoaniline in 89% yield.

Synthesis of 2-iodoaniline

Purification Methods

Distil 2-iodoaniline with steam and crystallise it from *benzene/pet ether. The N-acetyl derivative has m 110o. [Beilstein 12 IV 1542.]

2-Iodoaniline Preparation Products And Raw materials

Raw materials

Preparation Products

5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
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2-Iodoaniline Suppliers

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View Lastest Price from 2-Iodoaniline manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Iodoaniline 615-43-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-04
Henan Fengda Chemical Co., Ltd
Product
2-Iodoaniline 615-43-0
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-23
Dalian Richfortune Chemicals Co., Ltd
Product
2-Iodoaniline 615-43-0
Price
US $10.00/kg
Min. Order
100kg
Purity
99%
Supply Ability
10000kgs
Release date
2023-08-28

615-43-0, 2-IodoanilineRelated Search:

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  • AMINE
  • C2 to C6
  • Building Blocks
  • Amines
  • Organic Building Blocks
  • Nitrogen Compounds
  • Anilines, Aromatic Amines and Nitro Compounds
  • Amines
  • Phenyls & Phenyl-Het
  • Anilines, Amides & Amines
  • Iodine Compounds
  • Phenyls & Phenyl-Het
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  • Nitrogen Compounds
  • Pharmaceutical Intermediates
  • bc0001