ChemicalBook > CAS DataBase List > 4-Piperidineethanol

4-Piperidineethanol

Product Name: 4-Piperidineethanol
CAS No.: 622-26-4
Chemical Name: 4-Piperidineethanol
Synonyms: 2-(Piperidin-4-yl)ethan-1-ol;2-Piperidin-4-ylethanol;4-(2-HYDROXYETHYL)PIPERIDINE;4-Piperineethanol;4-ethanolpiperidine;4-PIPERIDINEETHANOL;piperidine-4-ethanol;PIPERIDIN-4-YLETHANOL;PIPERIDINEETHANOL(4-);Tirofiban Impurity 58
CBNumber: CB5151899
Molecular Formula: C7H15NO
Formula Weight: 129.2
MOL File: 622-26-4.mol

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4-Piperidineethanol Property

Melting point:: 46-47 °C (lit.)
Boiling point:: 131-136 °C/17 mmHg (lit.)
Density: 1.0059
refractive index: n20/D 1.4902(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
pka: 15.10±0.10(Predicted)
color: Brown
InChI: InChI=1S/C7H15NO/c9-6-3-7-1-4-8-5-2-7/h7-9H,1-6H2
InChIKey: LDSQQXKSEFZAPE-UHFFFAOYSA-N
SMILES: N1CCC(CCO)CC1
CAS DataBase Reference: 622-26-4(CAS DataBase Reference)
NIST Chemistry Reference: 4-Ethanolpiperidine(622-26-4)
EPA Substance Registry System: 4-Piperidineethanol (622-26-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P46156
Product name: 4-Piperidineethanol
Purity: 97%
Packaging: 1g
Price: $69
Updated: 2023/06/20

Sigma-Aldrich

Product number: P46156
Product name: 4-Piperidineethanol
Purity: 97%
Packaging: 5g
Price: $74
Updated: 2023/01/07

TCI Chemical

Product number: P0992
Product name: 4-Piperidineethanol
Purity: >96.0%(GC)(T)
Packaging: 5g
Price: $70
Updated: 2025/07/31

TCI Chemical

Product number: P0992
Product name: 4-Piperidineethanol
Purity: >96.0%(GC)(T)
Packaging: 25g
Price: $282
Updated: 2025/07/31

TRC

Product number: P481960
Product name: 4-Piperidineethanol
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

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4-Piperidineethanol Chemical Properties,Usage,Production

Chemical Properties

white crystalline low melting solid

Uses

Reactant for synthesis of:• ;Ursolic acid derivatives1• ;Amodiaquine analogues for treatment of cerebral malaria2• ;Spiroimidazolidinone NPC1L1 inhibitors3• ;Piperazinyl glutamate pyridines as orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation4• ;Neurokinin-2 receptor antagonists5• ;Hepatitis C virus NS5B polymerase inhibitors6

Uses

4-Piperidineethanol have been used as a intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK

Uses

4-Piperidineethanol have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK

Synthesis

51052-78-9

622-26-4

Lithium tetrahydroaluminum (0.06 mol) was added to ice-bath cooled anhydrous tetrahydrofuran (80 mL) under nitrogen protection, followed by the slow addition of crushed 4-piperidineacetic acid (4.95 g, 0.03 mol), and the temperature of the reaction was controlled to be no more than 30 °C. The reaction mixture was stirred at 25 °C overnight. Upon completion of the reaction, the system was cooled to 0 °C and water (3 mL), 30% aqueous sodium hydroxide solution (3 mL), and water (3 mL) were added sequentially and slowly dropwise. The resulting mixture was continued to be stirred at 25 °C for 30 min. Finally, the solvent was removed by distillation under reduced pressure to give 2.23 g of light yellow solid product in 62.5% yield.

References

[1] Patent: CN103755686, 2016, B. Location in patent: Paragraph 0099; 0100

4-Piperidineethanol Preparation Products And Raw materials

Raw materials

Platinum Ethanol 4-Methylpyridine tert-Butanol Sodium borohydride Carbon dioxide Tetrahydrofuran Diethyl ether Lithium Aluminum Hydride 1-Butanol Thionyl chloride Sodium amide

Preparation Products

QUINUCLIDINE HYDROCHLORIDE

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View Lastest Price from 4-Piperidineethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Piperidineethanol 622-26-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Honest Joy Holdings Limited

Product: 2-(Piperidin-4-yl)ethanol 622-26-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.5%
Supply Ability: 100 tons
Release date: 2022-02-20

Career Henan Chemical Co

Product: 4-Piperidineethanol 622-26-4
Price: US $1000.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-07-24

622-26-4, 4-PiperidineethanolRelated Search:

2-(METHYLSULFONYL)ETHANOL 2,2,6,6-Tetramethyl-4-piperidinol Haloperidol Triacetonediamine DROPERIDOL 4-Piperidinemethanol Diphenoxylate STRYCHNINE HYDROCHLORIDE THEBAINE Reserpine Yohimbine RESCINNAMINE 10,11-Dimethoxystrychnine NALORPHINE HYDROCHLORIDE SYROSINGOPINE BRUCINE SULFATE Raubasine PIPERIDINEETHANOL, 2-,2-PIPERIDINEETHANOL

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Tirofiban Impurity 58

4-Piperidineethanol&gt

4-Piperidineethanol (7CI, 9CI, ACI)

622-26-4

AMINE

Building Blocks

Piperidines

Heterocyclic Building Blocks

Building Blocks

C5 to C7

Chemical Synthesis

Heterocyclic Building Blocks

Piperidines

Piperidine