4-Chloro-N-methylpiperidine
- Product Name
- 4-Chloro-N-methylpiperidine
- CAS No.
- 5570-77-4
- Chemical Name
- 4-Chloro-N-methylpiperidine
- Synonyms
- 4-CHLORO-1-METHYLPIPERIDINE;N-METHYL-4-CHLORO PIPERIDINE;4-CHLORO-N-METHYL PIPERIDINE;oro-1-methyL;N-Methyl-4-chloro;N-methyl-4-cloperidine;N-Methyl-4-Chloropiperdine;4-chloro-1-methyl-piperidin;N-Methyl-4-chloropiperidene;N-methyl-4-ChIoropiperidine
- CBNumber
- CB5185205
- Molecular Formula
- C6H12ClN
- Formula Weight
- 133.62
- MOL File
- 5570-77-4.mol
4-Chloro-N-methylpiperidine Property
- Melting point:
- 160-165°C
- Boiling point:
- 162°C(lit.)
- Density
- 1.02
- vapor pressure
- 3.493hPa at 25℃
- refractive index
- 1.4670-1.4710
- Flash point:
- 48 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Ethanol (Slightly) , Methanol (Slightly)
- form
- clear liquid to slightly cloudy liquid
- pka
- 7.88±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- Water Solubility
- 1.533g/L at 29℃
- InChIKey
- MYGXGCCFTPKWIH-UHFFFAOYSA-N
- LogP
- 1.318 at 25℃
- CAS DataBase Reference
- 5570-77-4(CAS DataBase Reference)
- EPA Substance Registry System
- Piperidine, 4-chloro-1-methyl- (5570-77-4)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 10-34-36/38
- Safety Statements
- 22-24/25-45-36/37/39-26-36-16
- RIDADR
- 1993
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C2465
- Product name
- 4-Chloro-1-methylpiperidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- C2465
- Product name
- 4-Chloro-1-methylpiperidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $139
- Updated
- 2025/07/31
- Product number
- C371070
- Product name
- 4-Chloro-1-methylpiperidine
- Packaging
- 100g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- C371070
- Product name
- 4-Chloro-1-methylpiperidine
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FC29367
- Product name
- 4-Chloro-N-methylpiperidine
- Packaging
- 50g
- Price
- $80
- Updated
- 2021/12/16
4-Chloro-N-methylpiperidine Chemical Properties,Usage,Production
Chemical Properties
Clear colorless liquid
Uses
4-Chloro-1-methylpiperidine is a reactant in the synthesis of indole and benzimidazole piperazines as histamine H4 receptor antagonist.
Flammability and Explosibility
Not classified
Synthesis
931-20-4
103057-10-9
5570-77-4
To an anhydrous tetrahydrofuran (THF, 7 mL) solution of diisopropylamine (1.078 mL) was slowly added n-butyllithium (3.08 mL, 2.5 M) dropwise at 0 °C. The reaction solution was stirred at 0 °C for 40 min and then cooled to -23 °C. Subsequently, N-methyl-2-piperidone (0.80 mL) was added to the reaction system and stirred at -23°C for 0.5 hr, after which stirring was continued at -78°C for 1 hr. Next, a solution of anhydrous THF (14 mL) of 4-chloromethyl-N-tritylimidazole (2.70 g) was added dropwise to the above mixture. The reaction mixture was stirred at -78 °C for 4 hours, followed by slow warming to room temperature and stirring overnight (16 hours). Upon completion of the reaction, water and ethyl acetate were added to the mixture and the organic layer was separated after vigorous shaking. The aqueous layer was extracted several times with ethyl acetate and the combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by fast chromatography (eluent: dichloromethane solution of saturated methanol with 1% to 2% ammonia) to afford the target compound N-methyl-4-chloropiperidine (1.58 g, 52% yield).
Physiological effects
4-Chloro-N-methylpiperidine can be used to treat bronchial asthma, chronic obstructive pulmonary disease, and other respiratory disorders by inhibiting the production of histamine in the body. It also has antihistaminic effects that may be due to its ability to inhibit histamine release from mast cells or block H1 receptors.
References
[1] Patent: US5932596, 1999, A
[2] Patent: US5807872, 1998, A
4-Chloro-N-methylpiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-N-methylpiperidine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-Chloro-N-methylpiperidine manufacturers
- Product
- 4-Chloro-N-methylpiperidine 5570-77-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- 4-Chloro-N-methylpiperidine 5570-77-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-18
- Product
- 4-Chloro-N-methylpiperidine 5570-77-4
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2024-03-11