5-bromo-3-chloropyridine-2-carbonitrile
- Product Name
- 5-bromo-3-chloropyridine-2-carbonitrile
- CAS No.
- 945557-04-0
- Chemical Name
- 5-bromo-3-chloropyridine-2-carbonitrile
- Synonyms
- 5-broMo-3-chloropicolinonitrile;5-Bromo-3-chL;5-broMo-3-chloro-2-cyanopyridine;5-broMo-2-cyano-3-chloropyridine;5-Bromo-3-chloro-2-pyridinitrile;5-bromo-3-chloro-2-Pyridinecarbonitrile;5-bromo-3-chloropyridine-2-carbonitrile;5-bromo-3-chloropicolinonitrile 98%;2-Pyridinecarbonitrile, 5-bromo-3-chloro-;5-bromo-3-chloropyridine-2-carbonitrile ISO 9001：2015 REACH
- CBNumber
- CB52500343
- Molecular Formula
- C6H2BrClN2
- Formula Weight
- 217.45
- MOL File
- 945557-04-0.mol
5-bromo-3-chloropyridine-2-carbonitrile Property
- Boiling point:
- 289.0±35.0 °C(Predicted)
- Density
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- -4.96±0.20(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C6H2BrClN2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H
- InChIKey
- SIYPZKHSXDFDRA-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC=C(Br)C=C1Cl
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- B684413
- Product name
- 5-Bromo-3-chloropyridine-2-carbonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 070183
- Product name
- 5-Bromo-3-chloropyridine-2-carbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- OR17892
- Product name
- 5-Bromo-3-chloropyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 3H37-D-X6
- Product name
- 5-Bromo-3-chloropyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- FB140357
- Product name
- 5-Bromo-3-chloropicolinonitrile
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
5-bromo-3-chloropyridine-2-carbonitrile Chemical Properties,Usage,Production
Uses
5-Bromo-3-chloropyridine-2-carbonitrile is used as a reagent in organic synthesis. Its derivative 3-bromo-2-chloropyridine can be aminated with various substituted aminoethanols.
Synthesis
573675-27-1
945557-04-0
The general procedure for the synthesis of 5-bromo-3-chloro-2-pyridinecarbonitrile from 3-amino-5-bromo-2-pyridinecarbonitrile was as follows: to a suspension of 3-amino-5-bromo-2-cyano pyridine (198 mg, 1.00 mmol) in 37% hydrochloric acid (2.00 ml) and water (0.5 ml) at 0°C, sodium nitrite (83.0 mg, 1.20 mmol) and the reaction was stirred for 1 hour. Subsequently, copper powder (15 mg) was added and the mixture was refluxed for 30 minutes. After completion of the reaction, the mixture was cooled, the reaction was quenched with ice water and alkalized with 5N sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate and the organic phase was washed with brine and dried over anhydrous magnesium sulfate. The crude product was purified by silica gel column chromatography with 0-30% ethyl acetate/hexane as eluent to give 110 mg of 5-bromo-2-cyano-3-chloropyridine in 50% yield.
References
[1] Patent: WO2007/87488, 2007, A2. Location in patent: Page/Page column 24
[2] Patent: WO2011/51540, 2011, A1. Location in patent: Page/Page column 75
5-bromo-3-chloropyridine-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
5-bromo-3-chloropyridine-2-carbonitrile Suppliers
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
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View Lastest Price from 5-bromo-3-chloropyridine-2-carbonitrile manufacturers
- Product
- 5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-06