ChemicalBook > CAS DataBase List > SU14813

SU14813

Product Name
SU14813
CAS No.
627908-92-3
Chemical Name
SU14813
Synonyms
SU14813;CS-1149;SU-14813; SU 14813;SU14813, 10 mM in DMSO;SU14813(Random Configuration);5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide;(S)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide;5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N- [ 2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carb;5-[(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;1H-Pyrrole-3-carboxamide, 5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-
CBNumber
CB52516070
Molecular Formula
C23H27FN4O4
Formula Weight
442.48
MOL File
627908-92-3.mol
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SU14813 Property

Boiling point:
685.6±55.0 °C(Predicted)
Density 
1.341
storage temp. 
Store at -20°C
solubility 
DMSO : 44 mg/mL (99.44 mM; Need ultrasonic)
form 
Powder
pka
11.24±0.20(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

ChemScene
Product number
CS-0240
Product name
SU14813
Purity
98.90%
Packaging
5mg
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-0240
Product name
SU14813
Purity
98.90%
Packaging
10mg
Price
$114
Updated
2021/12/16
ApexBio Technology
Product number
A3844
Product name
SU14813
Packaging
2mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
A3844
Product name
SU14813
Packaging
5mg
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
A3844
Product name
SU14813
Packaging
10mg
Price
$307
Updated
2021/12/16
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SU14813 Chemical Properties,Usage,Production

Biological Activity

SU14813 (SU 014813) is a multi-receptor tyrosine kinase inhibitor with IC50 values of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit), respectively. It has potent antiangiogenic and antitumor activities.

in vitro

SU14813 inhibits ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets. It inhibits cellular ligand-dependent phosphorylation of VEGFR-2 (transfected NIH 3T3 cells) , PDGFR-β (transfected NIH 3T3 cells), KIT (Mo7e cells), and FLT3-internal tandem duplication (FLT3-ITD; MV4;11 cells) as well as FMS/CSF1R (transfected NIH 3T3 cells). SU14813 inhibits VEGFR- 2, PDGFR-β, and KIT phosphorylation in porcine aorta endothelial cells overexpressing these targets, with cellular IC 50 values of 5.2, 9.9, and 11.2 nM, respectively. Also it inhibits the growth of U-118MG with an IC 50 of 50 to 100 nM.

in vivo

SU14813 inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion. The plasma concentration required for in vivo target inhibition is estimated to be 100 to 200 ng/mL. Used as monotherapy, SU14813 exhibits broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduces growth of various established xenografts derived from human or rat tumor cell lines. Treatment in combination with docetaxel significantly enhances both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> KIT
(Cell-free assay)
TargetValue
VEGFR1
(Cell-free assay)		 2 nM
PDGFRβ
(Cell-free assay)		 4 nM
15 nM
VEGFR2
(Cell-free assay)		 50 nM

SU14813 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU14813 Suppliers

China 67 United States 12 Global 79
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
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View Lastest Price from SU14813 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
SU14813 627908-92-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Career Henan Chemical Co
Product
SU14813 627908-92-3
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

627908-92-3, SU14813Related Search:

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  • SU14813
  • 5-[(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • CS-1149
  • SU14813(Random Configuration)
  • SU-14813; SU 14813
  • 5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N- [ 2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carb
  • 1H-Pyrrole-3-carboxamide, 5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-
  • 5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • c-Kit,Inhibitor,VEGFR,Vascular endothelial growth factor receptor,SU 14813,PDGFR,CD117,Platelet-derived growth factor receptor,SU-14813,SU14813,inhibit,SCFR
  • (S)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • SU14813, 10 mM in DMSO
  • 627908-92-3