2,4,6-Triisopropylbenzenesulfonyl chloride
- Product Name
- 2,4,6-Triisopropylbenzenesulfonyl chloride
- CAS No.
- 6553-96-4
- Chemical Name
- 2,4,6-Triisopropylbenzenesulfonyl chloride
- Synonyms
- TPSCL;TPS;2,4,6-Triisopropylphenylsulfonyl chloride;2,4,6-Triisopropylbenzene-1-sulfonyl chloride;Trisyl chloride;TIMTEC-BB SBB001244;LABOTEST-BB LT00233201;TRI ARYL SULFONIUM CHLORIDE;2,4,6-Triisopropylbenzenesulf;Triisopropylbenzenesulfonyl chlorid
- CBNumber
- CB5251818
- Molecular Formula
- C15H23ClO2S
- Formula Weight
- 302.86
- MOL File
- 6553-96-4.mol
2,4,6-Triisopropylbenzenesulfonyl chloride Property
- Melting point:
- 92-94 °C (lit.)
- Boiling point:
- 378C
- Density
- 1.1012 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- ethanol: 50 mg/mL, clear
- form
- Crystalline Solid
- color
- White to slightly beige
- Water Solubility
- decomposes
- Sensitive
- Moisture Sensitive
- BRN
- 1218575
- InChI
- InChI=1S/C15H23ClO2S/c1-9(2)12-7-13(10(3)4)15(19(16,17)18)14(8-12)11(5)6/h7-11H,1-6H3
- InChIKey
- JAPYIBBSTJFDAK-UHFFFAOYSA-N
- SMILES
- C1(S(Cl)(=O)=O)=C(C(C)C)C=C(C(C)C)C=C1C(C)C
- CAS DataBase Reference
- 6553-96-4(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-29
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 21
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049020
- Storage Class
- 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- Skin Corr. 1B
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 119490
- Product name
- 2,4,6-Triisopropylbenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $87.9
- Updated
- 2026/03/19
- Product number
- 119490
- Product name
- 2,4,6-Triisopropylbenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 100g
- Price
- $217
- Updated
- 2026/03/19
- Product number
- T0459
- Product name
- 2,4,6-Triisopropylbenzenesulfonyl Chloride
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $21
- Updated
- 2026/03/19
- Product number
- T0459
- Product name
- 2,4,6-Triisopropylbenzenesulfonyl Chloride
- Purity
- >97.0%(T)
- Packaging
- 500g
- Price
- $269
- Updated
- 2026/03/19
- Product number
- T795575
- Product name
- 2,4,6-Triisopropylbenzenesulfonyl chloride
- Packaging
- 100g
- Price
- $250
- Updated
- 2021/12/16
2,4,6-Triisopropylbenzenesulfonyl chloride Chemical Properties,Usage,Production
Chemical Properties
White to cream solid
Uses
2,4,6-Triisopropylbenzenesulfonyl chloride is used for the synthesis of glycerophospholipids as a condensing agent and in the analysis of phosphonolipids in egg yolk by HPLC/MS technique. It acts as a coupling reagent for the synthesis of oligonucleotides and as sulfonates of pyrimidine nucleosides. It also serves as a condensing agent in the synthesis of hydrogen-phosphonate diesters.
Uses
2,4,6-Triisopropylbenzenesulfonyl chloride can be used in the analysis of phosphonolipids in eggyolk by HPLC/MS technique.
It can also be used to synthesize:
- Dimeric neomycin-neomycin conjugate with a flexible linker, 2,2′-(ethylenedioxy)bis(ethylamine).
- Coupling reagents for the synthesis of oligonucleotides.
- Sulfonates of pyrimidine nucleosides. These sulfonates can be displaced by nucleophiles in the presence of palladium-catalysts.
Synthesis
1) 1000mL four-necked bottle, add 2,4,6-triisopropylbenzene 72.0g, add sodium sulfate 3.6g under stirring, ice bath cooling to below 5 , control the reaction temperature of 5-15 , control 1.5-2.0 hours, from the dropping funnel slowly added primary chlorosulfuric acid 77.0g, add the graduation, at 10-15 holding reaction 0.5 hours.
2) control the reaction temperature for 15-25 , control 0.5-1.0 hours, from the drop funnel slowly add 145.0g of secondary chlorosulfonic acid, add, at 20-25 insulation reaction 2.0 hours to produce sulfonated material;
3) 1000mL beaker, add 150g of ice and water mixture, start stirring, the above sulfonated material slowly added to the ice and water, at 15 below the role of 15 minutes to maintain the material placed in the liquid funnel static for 30 minutes, separated out the lower organic layer of the system 2,4,6-triisopropylbenzenesulfonyl chloride 128.8g, yield 98.3%.
2,4,6-Triisopropylbenzenesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,6-Triisopropylbenzenesulfonyl chloride manufacturers
- Product
- 2, 4, 6-Triisopropylbenzenesulfonyl Chloride 6553-96-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-28
- Product
- 2,4,6-Triisopropylbenzenesulfonyl chloride 6553-96-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-26
- Product
- 2, 4, 6-Triisopropylbenzenesulfonyl Chloride 6553-96-4
- Price
- US $10.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21