BIX 02189

ChemicalBook > CAS DataBase List > BIX 02189

Product Name: BIX 02189
CAS No.: 1094614-85-3
Chemical Name: BIX 02189
Synonyms: CS-39;CS-1936;bix 2189;BIX 02189;BIX02189（c）;(E/Z)-BIX02189;BIX 02189, >=98%;BIX 02189 USP/EP/BP;BIX-02189(Random Configuration);BIX-02189 Random Configuration BIX02189
CBNumber: CB52537538
Molecular Formula: C27H28N4O2
Formula Weight: 440.54
MOL File: 1094614-85-3.mol

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BIX 02189 Property

Melting point:: >250°C (dec.)
Boiling point:: 653.4±55.0 °C(Predicted)
Density: 1.230
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 11.24±0.20(Predicted)
color: Yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

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N-Bromosuccinimide Price

Tocris

Product number: 4842
Product name: BIX02189
Purity: ≥98%(HPLC)
Packaging: 10
Price: $221
Updated: 2021/12/16

Tocris

Product number: 4842
Product name: BIX02189
Purity: ≥98%(HPLC)
Packaging: 50
Price: $909
Updated: 2021/12/16

Usbiological

Product number: 254779
Product name: BIX 02189
Packaging: 10mg
Price: $480
Updated: 2021/12/16

TRC

Product number: B591690
Product name: BIX02189
Packaging: 5mg
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 474076
Product name: BIX 02189
Packaging: 100mg
Price: $1848
Updated: 2021/12/16

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BIX 02189 Chemical Properties,Usage,Production

Uses

BIX 02189 inhibits TGF-β1-induced lung cancer cell metastasis by directly targeting TGF-β type I receptor.

Uses

BIX02189 MEK inhibitor, prevents cell proliferation and induces apoptosis. Can be applied towards treatments of cancers and proliferative cell diseases.

Definition

ChEBI: 3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide is an indolecarboxamide.

Biological Activity

bix 02189 is a selective inhibitor of mek5 with ic50 value of 1.5 nm 1.bix 02189 belongs to the indolinone kinase inhibitor series. it selectively inhibited the catalytic activity of mek5 but not other closely related kinases such as mek1, mek2, erk2 and jnk2. bix 02189 also inhibited erk5 with ic50 value of 59 nm. in hela cells, treatment of bix 02189 inhibited the phosphorylation of erk5 but not erk1/2. besides that, bix 02189 prevented the transcription of the downstream substrate mef2c in hela and hek293 cells. moreover, in a three-dimensional lymphangiogenic sprouting assay, bix 02189 resulted in an inhibition of lymphangiogenic sprouting with a minimal effective concentration of 1 μm 1,2.

target

MEK5

References

1. tatake r j, o’neill m m, kennedy c a, et al. identification of pharmacological inhibitors of the mek5/erk5 pathway. biochemical and biophysical research communications, 2008, 377(1): 120-125.2. schulz m m p, reisen f, zgraggen s, et al. phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. proceedings of the national academy of sciences, 2012, 109(40): e2665-e2674.

BIX 02189 Preparation Products And Raw materials

Raw materials

Preparation Products

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1094614-85-3, BIX 02189Related Search:

Dimethyl sulfoxide Y16 TENOVIN-1 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BMS 833923 MS436 CNX-1351 Mutant IDH1 inhibitor Selumetinib Saracatinib XMD8-92 SCH772984 Tofacitinib PLX4032

BIX 02189

(3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylene]-N,N-dimethyl-2-oxo-6-indolinecarboxamide

bix 2189

CS-1936

CS-39

3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide BIX 02189

BIX 02189, >=98%

(Z)-3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6

BIX-02189(Random Configuration)

(E/Z)-BIX02189

1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-

BIX 02189 USP/EP/BP

BIX-02189 Random Configuration BIX02189

BIX02189（c）

1094614-85-3

Inhibitors

MAPK