ChemicalBook > CAS DataBase List > BIX 02189

BIX 02189

Product Name
BIX 02189
CAS No.
1094614-85-3
Chemical Name
BIX 02189
Synonyms
CS-39;CS-1936;bix 2189;BIX 02189;BIX02189(c);(E/Z)-BIX02189;BIX 02189, >=98%;BIX 02189 USP/EP/BP;BIX-02189(Random Configuration);BIX-02189 Random Configuration BIX02189
CBNumber
CB52537538
Molecular Formula
C27H28N4O2
Formula Weight
440.54
MOL File
1094614-85-3.mol
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BIX 02189 Property

Melting point:
>250°C (dec.)
Boiling point:
653.4±55.0 °C(Predicted)
Density 
1.230
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
11.24±0.20(Predicted)
color 
Yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
4842
Product name
BIX02189
Purity
≥98%(HPLC)
Packaging
10
Price
$221
Updated
2021/12/16
Tocris
Product number
4842
Product name
BIX02189
Purity
≥98%(HPLC)
Packaging
50
Price
$909
Updated
2021/12/16
TRC
Product number
B591690
Product name
BIX02189
Packaging
5mg
Price
$165
Updated
2021/12/16
Usbiological
Product number
254779
Product name
BIX 02189
Packaging
10mg
Price
$480
Updated
2021/12/16
Usbiological
Product number
474076
Product name
BIX 02189
Packaging
100mg
Price
$1848
Updated
2021/12/16
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BIX 02189 Chemical Properties,Usage,Production

Uses

BIX 02189 inhibits TGF-β1-induced lung cancer cell metastasis by directly targeting TGF-β type I receptor.

Uses

BIX02189 MEK inhibitor, prevents cell proliferation and induces apoptosis. Can be applied towards treatments of cancers and proliferative cell diseases.

Definition

ChEBI: 3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide is an indolecarboxamide.

Biological Activity

bix 02189 is a selective inhibitor of mek5 with ic50 value of 1.5 nm 1.bix 02189 belongs to the indolinone kinase inhibitor series. it selectively inhibited the catalytic activity of mek5 but not other closely related kinases such as mek1, mek2, erk2 and jnk2. bix 02189 also inhibited erk5 with ic50 value of 59 nm. in hela cells, treatment of bix 02189 inhibited the phosphorylation of erk5 but not erk1/2. besides that, bix 02189 prevented the transcription of the downstream substrate mef2c in hela and hek293 cells. moreover, in a three-dimensional lymphangiogenic sprouting assay, bix 02189 resulted in an inhibition of lymphangiogenic sprouting with a minimal effective concentration of 1 μm 1,2.

target

MEK5

References

1. tatake r j, o’neill m m, kennedy c a, et al. identification of pharmacological inhibitors of the mek5/erk5 pathway. biochemical and biophysical research communications, 2008, 377(1): 120-125.2. schulz m m p, reisen f, zgraggen s, et al. phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. proceedings of the national academy of sciences, 2012, 109(40): e2665-e2674.

BIX 02189 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX 02189 Suppliers

A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1094614-85-3, BIX 02189Related Search:


  • BIX 02189
  • (3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylene]-N,N-dimethyl-2-oxo-6-indolinecarboxamide
  • bix 2189
  • CS-1936
  • CS-39
  • 3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
  • 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
  • (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
  • 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide BIX 02189
  • BIX 02189, >=98%
  • (Z)-3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6
  • BIX-02189(Random Configuration)
  • (E/Z)-BIX02189
  • 1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-
  • BIX 02189 USP/EP/BP
  • BIX-02189 Random Configuration BIX02189
  • BIX02189(c)
  • 1094614-85-3
  • Inhibitors
  • MAPK