METHYL 5-BROMOSALICYLATE
- Product Name
- METHYL 5-BROMOSALICYLATE
- CAS No.
- 4068-76-2
- Chemical Name
- METHYL 5-BROMOSALICYLATE
- Synonyms
- AKOS BBB/379;AURORA KA-2528;ASISCHEM D13384;BUTTPARK 41\07-02;TIMTEC-BB SBB002397;RARECHEM AL BF 0040;LABOTEST-BB LT00033612;METHYL 5-BROMOSALICYLATE;Methyl-5-BroMo Salysilate;Methyl 5-bromosalicylate ,95%
- CBNumber
- CB5259829
- Molecular Formula
- C8H7BrO3
- Formula Weight
- 231.04
- MOL File
- 4068-76-2.mol
METHYL 5-BROMOSALICYLATE Property
- Melting point:
- 61-65 °C (lit.)
- Boiling point:
- 266.6±20.0 °C(Predicted)
- Density
- 1.627±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.19±0.18(Predicted)
- form
- Solid
- color
- White to pale brown
- InChI
- InChI=1S/C8H7BrO3/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4,10H,1H3
- InChIKey
- FJYDBKPPGRZSOZ-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC(Br)=CC=C1O
- CAS DataBase Reference
- 4068-76-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 124621
- Product name
- Methyl 5-bromosalicylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $23.35
- Updated
- 2025/07/31
- Product number
- 124621
- Product name
- Methyl 5-bromosalicylate
- Purity
- 95%
- Packaging
- 25g
- Price
- $194
- Updated
- 2025/07/31
- Product number
- B6380
- Product name
- Methyl 5-Bromo-2-hydroxybenzoate
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $96
- Updated
- 2025/07/31
- Product number
- B6380
- Product name
- Methyl 5-Bromo-2-hydroxybenzoate
- Purity
- min. 95.0 %
- Packaging
- 25G
- Price
- $288
- Updated
- 2025/07/31
- Product number
- M296070
- Product name
- Methyl 5-bromosalicylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
METHYL 5-BROMOSALICYLATE Chemical Properties,Usage,Production
Uses
Methyl 5-bromosalicylate was used as starting reagent in the synthesis of immobilization precursor of photoswitchable piperidine base.
Synthesis
67-56-1
89-55-4
4068-76-2
General procedure for the synthesis of methyl 5-bromosalicylate from methanol and 5-bromosalicylic acid: Step a) Synthesis of methyl 5-bromosalicylate: thionyl chloride (440 g, 3.7 mol) was slowly added to a solution of toluene (2 L) containing 5-bromosalicylic acid (200 g, 0.92 mol) at 0 °C and the reaction was stirred. The reaction mixture was then heated to 70 °C and refluxed for 40 hours. Upon completion of the reaction, the excess solvent was removed by distillation. Ethyl acetate (2 L) was added to the crude product for dissolution, and the organic layer was washed sequentially with 10% cold aqueous sodium bicarbonate (2 x 1 L) and brine, and then dried. Finally, the solvent was removed by vacuum to afford methyl 5-bromosalicylate as a low melting point solid (190 g, 89% yield). TLC conditions: petroleum ether/ethyl acetate (7:3), Rf value: 0.6.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 10, p. 2621 - 2625
[2] Journal of Materials Chemistry, 1996, vol. 6, # 8, p. 1297 - 1307
[3] Organic Letters, 2014, vol. 16, # 19, p. 5140 - 5143
[4] Patent: WO2005/12280, 2005, A1. Location in patent: Page/Page column 46-47
[5] Patent: WO2005/11685, 2005, A1. Location in patent: Page/Page column 41
METHYL 5-BROMOSALICYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 5-BROMOSALICYLATE manufacturers
- Product
- METHYL 5-BROMOSALICYLATE 4068-76-2
- Price
- US $30.00-20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-07-30
- Product
- Methyl 5-Bromosalicylate 4068-76-2
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-25