METHYL 5-BROMOSALICYLATE

Product Name: METHYL 5-BROMOSALICYLATE
CAS No.: 4068-76-2
Chemical Name: METHYL 5-BROMOSALICYLATE
Synonyms: AKOS BBB/379;AURORA KA-2528;ASISCHEM D13384;BUTTPARK 41\07-02;TIMTEC-BB SBB002397;RARECHEM AL BF 0040;LABOTEST-BB LT00033612;METHYL 5-BROMOSALICYLATE;Methyl-5-BroMo Salysilate;Methyl 5-bromosalicylate ,95%
CBNumber: CB5259829
Molecular Formula: C8H7BrO3
Formula Weight: 231.04
MOL File: 4068-76-2.mol

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METHYL 5-BROMOSALICYLATE Property

Melting point:: 61-65 °C (lit.)
Boiling point:: 266.6±20.0 °C(Predicted)
Density: 1.627±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.19±0.18(Predicted)
form: Solid
color: White to pale brown
InChI: InChI=1S/C8H7BrO3/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4,10H,1H3
InChIKey: FJYDBKPPGRZSOZ-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC(Br)=CC=C1O
CAS DataBase Reference: 4068-76-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 124621
Product name: Methyl 5-bromosalicylate
Purity: 95%
Packaging: 5g
Price: $23.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: 124621
Product name: Methyl 5-bromosalicylate
Purity: 95%
Packaging: 25g
Price: $194
Updated: 2025/07/31

TCI Chemical

Product number: B6380
Product name: Methyl 5-Bromo-2-hydroxybenzoate
Purity: min. 95.0 %
Packaging: 5G
Price: $96
Updated: 2025/07/31

TCI Chemical

Product number: B6380
Product name: Methyl 5-Bromo-2-hydroxybenzoate
Purity: min. 95.0 %
Packaging: 25G
Price: $288
Updated: 2025/07/31

TRC

Product number: M296070
Product name: Methyl 5-bromosalicylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

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METHYL 5-BROMOSALICYLATE Chemical Properties,Usage,Production

Uses

Methyl 5-bromosalicylate was used as starting reagent in the synthesis of immobilization precursor of photoswitchable piperidine base.

Synthesis

67-56-1

89-55-4

4068-76-2

General procedure for the synthesis of methyl 5-bromosalicylate from methanol and 5-bromosalicylic acid: Step a) Synthesis of methyl 5-bromosalicylate: thionyl chloride (440 g, 3.7 mol) was slowly added to a solution of toluene (2 L) containing 5-bromosalicylic acid (200 g, 0.92 mol) at 0 °C and the reaction was stirred. The reaction mixture was then heated to 70 °C and refluxed for 40 hours. Upon completion of the reaction, the excess solvent was removed by distillation. Ethyl acetate (2 L) was added to the crude product for dissolution, and the organic layer was washed sequentially with 10% cold aqueous sodium bicarbonate (2 x 1 L) and brine, and then dried. Finally, the solvent was removed by vacuum to afford methyl 5-bromosalicylate as a low melting point solid (190 g, 89% yield). TLC conditions: petroleum ether/ethyl acetate (7:3), Rf value: 0.6.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 10, p. 2621 - 2625
[2] Journal of Materials Chemistry, 1996, vol. 6, # 8, p. 1297 - 1307
[3] Organic Letters, 2014, vol. 16, # 19, p. 5140 - 5143
[4] Patent: WO2005/12280, 2005, A1. Location in patent: Page/Page column 46-47
[5] Patent: WO2005/11685, 2005, A1. Location in patent: Page/Page column 41

METHYL 5-BROMOSALICYLATE Preparation Products And Raw materials

Raw materials

Bromine Acetic acid Methanol Methyl salicylate

Preparation Products

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METHYL 5-BROMOSALICYLATE Suppliers

Austria 1 China 142 Germany 5 India 6 Russia 1 Slovakia 1 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 20 Global 185

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View Lastest Price from METHYL 5-BROMOSALICYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 5-BROMOSALICYLATE 4068-76-2
Price: US $30.00-20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-07-30

Career Henan Chemical Co

Product: Methyl 5-Bromosalicylate 4068-76-2
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-25

4068-76-2, METHYL 5-BROMOSALICYLATERelated Search:

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 5-Bromo-6-methoxynicotinic acid methyl ester METHYL 5-BROMO-2-FUROATE Methyl 5-bromo-2-chloropyridine-3-carboxylate Methyl-5-bromo-2 pyrimidine carboxylate Methyl 5-Bromo-2-Methyl-2H-1,2,3-triazole-4-carboxylate 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE METHYL 5-BROMO-2-IODOBENZOATE Methyl 5-bromo-6-chloropyridine-3-carboxylate METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE 5-BROMO-2-BROMOMETHYL-BENZOIC ACID METHYL ESTER methyl 5-bromo-1H-pyrrole-2-carboxylate Methyl 5-bromo-2-formylbenzoate, 98% Methyl 5-broMo-1H-pyrazole-3-carboxylate Methyl 5-Bromo-1-methyl-1H-1,2,3-triazole-4-carboxylate METHYL 5-BROMOPYRAZINE-2-CARBOXYLATE 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Methyl 5-bromonicotinate

RARECHEM AL BF 0040

TIMTEC-BB SBB002397

AKOS BBB/379

5-BROMOSALICYLIC ACID METHYL ESTER

JR-13535, Methyl 5-bromo-2-hydroxybenzoate, 95%

2-(4-chlorophenyl)-1,3-thiazinane

ASISCHEM D13384

AURORA KA-2528

BUTTPARK 41\07-02

METHYL 5-BROMOSALICYLATE

METHYL 5-BROMO-2-HYDROXYBENZENECARBOXYLATE

LABOTEST-BB LT00033612

PHENYLAZOFORMIC ACID 2-PHENYLHYDRAZIDE S

2-Hydroxy-5-bromobenzoic acid methyl ester

5-Bromo-2-hydroxybenzoic acid methyl ester

Methyl 5-bromosalicylate ,95%

Methyl-5-BroMo Salysilate

Methyl 5-broMosalicylate, 98+%

Benzoic acid, 5-bromo-2-hydroxy-, methyl ester

methyl 5-bromo-2-hydrxoybenzoate

5-Bromo methyl salicylate CAS No 4068-76-2

Methyl 2-Hydroxy-5-Bromobenzoate

4068-76-2

BrC6H32OHCO2CH3

Carbonyl Compounds

C8 to C9

Building Blocks

Organic Building Blocks

Esters

Aromatic Esters

C8 to C9

Carbonyl Compounds

Esters