ChemicalBook > CAS DataBase List > 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

Product Name
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
CAS No.
1332708-14-1
Chemical Name
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
Synonyms
CS-2357;N-benzyl-4-[(2-methylpropyl)amino]-2-{4-[(oxan-3-yl)methyl]piperazin-1-yl}pyrimidine-5-carboxamide;N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide;4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide;5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-;PF 4840154,PF-4840154,licking,nocifensive,Inhibitor,non-electrophilic,PF4840154,inhibit,Transient receptor potential channels,behavior,TRP Channel
CBNumber
CB52702880
Molecular Formula
C26H38N6O2
Formula Weight
466.62
MOL File
1332708-14-1.mol
More
Less

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Property

Density 
1.164±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
pka
13.71±0.46(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
10mg
Price
$243
Updated
2024/03/01
ChemScene
Product number
CS-5066
Product name
PF-4840154
Purity
99.59%
Packaging
10mg
Price
$600
Updated
2021/12/16
More
Less

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Chemical Properties,Usage,Production

Biological Activity

PF-4840154 is a potent and selective rat and human TrpA1 channel agonist with EC50 of 97 and 23 nM, respectively. PF-4840154 induces TrpA1-mediated nociceptive behavior in mice.

in vivo

PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse.

Animal Model: Female CD1 mice (25-30g) (In TrpA1+/+ mice)
Dosage: 30 nmol
Administration: Intraplantar (i.pl) injection
Result: Elicited robust licking behavior.

target

IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Suppliers

China 36 United States 8 Global 44
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1332708-14-1, 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-Related Search:

PF-06700841-TsOH PF-06700841 tosylate PF-06282999 PF 4618433 PF-06650833 PF-6260933 PF-01247324 PF 04995274 PNU 100480 PF 05175157 PF-06281355 PF06869206

  • 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
  • N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide
  • CS-2357
  • 4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide
  • PF 4840154,PF-4840154,licking,nocifensive,Inhibitor,non-electrophilic,PF4840154,inhibit,Transient receptor potential channels,behavior,TRP Channel
  • N-benzyl-4-[(2-methylpropyl)amino]-2-{4-[(oxan-3-yl)methyl]piperazin-1-yl}pyrimidine-5-carboxamide
  • 1332708-14-1
  • C26H38N6O2