Cerdulatinib HCl salt

Product Name: Cerdulatinib HCl salt
CAS No.: 1369761-01-2
Chemical Name: Cerdulatinib HCl salt
Synonyms: Cerdulatinib HCl;Cerdulatinib HCl salt;PRT2070 hydrochloride;PRT062070 hydrochloride;Cerdulatinib hydrochloride;Cerdulatinib HCl (PRT-2070;Cerdulatinib HCl salt USP/EP/BP;Cerdulatinib (PRT062070, PRT2070);4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride;4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)
CBNumber: CB52728651
Molecular Formula: C20H28ClN7O3S
Formula Weight: 481.99942
MOL File: 1369761-01-2.mol

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Cerdulatinib HCl salt Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO:20.0(Max Conc. mg/mL);41.49(Max Conc. mM)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0010193
Product name: Cerdulatinib(hydrochloride)
Purity: 99.54%
Packaging: 5mg
Price: $108
Updated: 2021/12/16

ChemScene

Product number: CS-0010193
Product name: Cerdulatinib(hydrochloride)
Purity: 99.54%
Packaging: 10mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-0010193
Product name: Cerdulatinib(hydrochloride)
Purity: 99.54%
Packaging: 50mg
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0002513
Product name: 4-(CYCLOPROPYLAMINO)-2-[[4-[4-(ETHYLSULFONYL)-1-PIPERAZINYL]PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.01
Updated: 2021/12/16

ChemScene

Product number: CS-0010193
Product name: Cerdulatinib(hydrochloride)
Purity: 99.54%
Packaging: 100mg
Price: $744
Updated: 2021/12/16

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Cerdulatinib HCl salt Chemical Properties,Usage,Production

Biological Activity

Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.

in vitro

Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.

in vivo

In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> ARK5
(Cell-free assay)

Target	Value
TYK2 (Cell-free assay)	0.5 nM
MST1 (Cell-free assay)	4 nM
4 nM
MLK1 (Cell-free assay)	5 nM
Fms (Cell-free assay)	5 nM

Cerdulatinib HCl salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Cerdulatinib HCl salt Suppliers

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1369761-01-2, Cerdulatinib HCl saltRelated Search:

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Cerdulatinib HCl salt

4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)

Cerdulatinib (PRT062070, PRT2070)

Cerdulatinib HCl

Cerdulatinib hydrochloride

PRT062070 hydrochloride

PRT2070 hydrochloride

Cerdulatinib HCl salt USP/EP/BP

4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride

Cerdulatinib HCl (PRT-2070

1369761-01-2

C20H28ClN7O3S

Inhibitors