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Cerdulatinib HCl salt

Product Name
Cerdulatinib HCl salt
CAS No.
1369761-01-2
Chemical Name
Cerdulatinib HCl salt
Synonyms
Cerdulatinib HCl;Cerdulatinib HCl salt;PRT2070 hydrochloride;PRT062070 hydrochloride;Cerdulatinib hydrochloride;Cerdulatinib HCl (PRT-2070;Cerdulatinib HCl salt USP/EP/BP;Cerdulatinib (PRT062070, PRT2070);Cerdulatinib|||PRT2070|||PRT062070 hydrochloride|||PRT062070|||PRT2070 hydrochloride;4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride
CBNumber
CB52728651
Molecular Formula
C20H28ClN7O3S
Formula Weight
481.99942
MOL File
1369761-01-2.mol
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Cerdulatinib HCl salt Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO:20.0(Max Conc. mg/mL);41.49(Max Conc. mM)
form 
Solid
color 
Light brown to brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0010193
Product name
Cerdulatinib(hydrochloride)
Purity
99.54%
Packaging
5mg
Price
$108
Updated
2021/12/16
ChemScene
Product number
CS-0010193
Product name
Cerdulatinib(hydrochloride)
Purity
99.54%
Packaging
10mg
Price
$144
Updated
2021/12/16
ChemScene
Product number
CS-0010193
Product name
Cerdulatinib(hydrochloride)
Purity
99.54%
Packaging
50mg
Price
$480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0002513
Product name
4-(CYCLOPROPYLAMINO)-2-[[4-[4-(ETHYLSULFONYL)-1-PIPERAZINYL]PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$500.01
Updated
2021/12/16
ChemScene
Product number
CS-0010193
Product name
Cerdulatinib(hydrochloride)
Purity
99.54%
Packaging
100mg
Price
$744
Updated
2021/12/16
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Cerdulatinib HCl salt Chemical Properties,Usage,Production

Biological Activity

Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.

in vitro

Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.

in vivo

In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> ARK5
(Cell-free assay)
TargetValue
TYK2
(Cell-free assay)		 0.5 nM
MST1
(Cell-free assay)		 4 nM
4 nM
MLK1
(Cell-free assay)		 5 nM
Fms
(Cell-free assay)		 5 nM

Cerdulatinib HCl salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Cerdulatinib HCl salt Suppliers

China 37 India 1 United States 8 Global 46
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1369761-01-2, Cerdulatinib HCl saltRelated Search:

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  • Cerdulatinib HCl salt
  • 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)
  • Cerdulatinib (PRT062070, PRT2070)
  • Cerdulatinib HCl
  • Cerdulatinib hydrochloride
  • PRT062070 hydrochloride
  • PRT2070 hydrochloride
  • Cerdulatinib HCl salt USP/EP/BP
  • 4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride
  • Cerdulatinib HCl (PRT-2070
  • Cerdulatinib|||PRT2070|||PRT062070 hydrochloride|||PRT062070|||PRT2070 hydrochloride
  • 1369761-01-2
  • C20H28ClN7O3S
  • Inhibitors