Cerdulatinib HCl salt
- Product Name
- Cerdulatinib HCl salt
- CAS No.
- 1369761-01-2
- Chemical Name
- Cerdulatinib HCl salt
- Synonyms
- Cerdulatinib HCl;Cerdulatinib HCl salt;PRT2070 hydrochloride;PRT062070 hydrochloride;Cerdulatinib hydrochloride;Cerdulatinib HCl (PRT-2070;Cerdulatinib HCl salt USP/EP/BP;Cerdulatinib (PRT062070, PRT2070);4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride;4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)
- CBNumber
- CB52728651
- Molecular Formula
- C20H28ClN7O3S
- Formula Weight
- 481.99942
- MOL File
- 1369761-01-2.mol
Cerdulatinib HCl salt Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);41.49(Max Conc. mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0010193
- Product name
- Cerdulatinib(hydrochloride)
- Purity
- 99.54%
- Packaging
- 5mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-0010193
- Product name
- Cerdulatinib(hydrochloride)
- Purity
- 99.54%
- Packaging
- 10mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- CS-0010193
- Product name
- Cerdulatinib(hydrochloride)
- Purity
- 99.54%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- KIN0002513
- Product name
- 4-(CYCLOPROPYLAMINO)-2-[[4-[4-(ETHYLSULFONYL)-1-PIPERAZINYL]PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.01
- Updated
- 2021/12/16
- Product number
- CS-0010193
- Product name
- Cerdulatinib(hydrochloride)
- Purity
- 99.54%
- Packaging
- 100mg
- Price
- $744
- Updated
- 2021/12/16
Cerdulatinib HCl salt Chemical Properties,Usage,Production
Biological Activity
Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.
in vitro
Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.
in vivo
In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.
target
| Target | Value |
| TYK2 (Cell-free assay) | 0.5 nM |
| MST1 (Cell-free assay) | 4 nM |
| 4 nM | |
| MLK1 (Cell-free assay) | 5 nM |
| Fms (Cell-free assay) | 5 nM |