LY2584702
- Product Name
- LY2584702
- CAS No.
- 1082949-67-4
- Chemical Name
- LY2584702
- Synonyms
- CS-1752;LY2584702;LY2584702 BASE;LY2584702 TsOH;LY2584702 USP/EP/BP;LY-2584702 (free base);LYS6K2, S6 kinase inhibitor;LY-2584702 free base (LY2584702);4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
- CBNumber
- CB52728813
- Molecular Formula
- C21H19F4N7
- Formula Weight
- 445.42
- MOL File
- 1082949-67-4.mol
LY2584702 Property
- storage temp.
- RT (des.)
- solubility
- Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
- form
- solid
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- L486540
- Product name
- LY2584702
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- L486540
- Product name
- LY2584702
- Packaging
- 25mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- BISN0247
- Product name
- Ly2584702
- Packaging
- 25mg
- Price
- $348
- Updated
- 2021/12/16
- Product number
- KIN0002488
- Product name
- LY-2584702
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.65
- Updated
- 2021/12/16
- Product number
- orb611834
- Product name
- LY-2584702 free base
- Packaging
- 50mg
- Price
- $584.8
- Updated
- 2021/12/16
LY2584702 Chemical Properties,Usage,Production
Description
LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.
Uses
LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.
References
1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441
LY2584702 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2584702 Suppliers
- Tel
- --
- Fax
- --
- info@axonmedchem.com
- Country
- The Netherlands
- ProdList
- 477
- Advantage
- 30