ChemicalBook > CAS DataBase List > DBCO-PEG4-maleimide

DBCO-PEG4-maleimide

Product Name
DBCO-PEG4-maleimide
CAS No.
1480516-75-3
Chemical Name
DBCO-PEG4-maleimide
Synonyms
DBCO-PEG4-MAL;DBCO-dPEG??-MAL;DBCO-NHCO-PEG4-BMPA;DBCO-PEG4-maleimide;DBCO-NH-PEG4-Maleimide;DBCO-NHCO-PEG4-NH-Maleimide;Dibenzocyclooctyne-PEG4-maleimide;DBCO-PEG4-Maleimide?Chemical Structure;DBCO-PEG4-Maleimide,Dibenzocyclooctyne-PEG4-maleimide;[DBCO-PEG-MAL] α-Dibenzocyclooctyne-ω-maleimide poly(ethylene glycol)
CBNumber
CB52925269
Molecular Formula
C36H42N4O9
Formula Weight
674.74
MOL File
1480516-75-3.mol
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DBCO-PEG4-maleimide Property

Boiling point:
965.2±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO, DCM, DMF
pka
15.01±0.46(Predicted)
form 
Viscous liquid
color 
Colorless to light yellow
InChIKey
VVFZXPZWVJMYPX-UHFFFAOYSA-N
SMILES
N1(CCC(NCCOCCOCCOCCOCCC(=O)NCCC(N2CC3=CC=CC=C3C#CC3=CC=CC=C23)=O)=O)C(=O)C=CC1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
760676
Product name
Dibenzocyclooctyne-PEG4-maleimide
Purity
for Copper-free Click Chemistry
Packaging
1MG
Price
$39.9
Updated
2023/06/20
Sigma-Aldrich
Product number
760676
Product name
Dibenzocyclooctyne-PEG4-maleimide
Purity
for Copper-free Click Chemistry
Packaging
5MG
Price
$134
Updated
2023/06/20
Sigma-Aldrich
Product number
760676
Product name
Dibenzocyclooctyne-PEG4-maleimide
Purity
for Copper-free Click Chemistry
Packaging
50MG
Price
$458
Updated
2023/06/20
Alfa Aesar
Product number
J65673
Product name
Azadibenzocyclooctyne-PEG4-maleimide
Packaging
10mg
Price
$148
Updated
2023/06/20
Alfa Aesar
Product number
J65673
Product name
Azadibenzocyclooctyne-PEG4-maleimide
Packaging
25mg
Price
$301
Updated
2023/06/20
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DBCO-PEG4-maleimide Chemical Properties,Usage,Production

Description

DBCO-PEG4-Maleimide is PEG linker containing a maleimide group and a DBCO moiety. The hydrophilic PEG spacer arm improves solubility in aqueous buffers. Maleimide group specifically and efficiently reacts with thiols to form stable thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
Applications Include:

  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

DBCO-PEG4-maleimide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DBCO-PEG4-maleimide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-PEG4-Maleimide 1480516-75-3
Price
US $0.00/mg
Min. Order
25mg
Purity
>99.00%
Supply Ability
100
Release date
2024-03-20

1480516-75-3, DBCO-PEG4-maleimideRelated Search:

DBCO-PEG4-biotin DBCO-PEG4-Benzylamine DBCO-PEG4-Val-Cit-PAB-PNP DBCO-PEG4-DBCO DBCO-PEG4-SE DBCO-PEG4-amine DBCO-maleimide DBCO-PEG4-Acid DBCO-PEG3-amine DBCO-PEG5-CH2CH2COOH DBCO-PEG4-amine BDP FL DBCO DBCO-PEG4-TAMRA DBCO-amine 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

  • DBCO-PEG4-maleimide
  • Dibenzocyclooctyne-PEG4-maleimide
  • DBCO-NH-PEG4-Maleimide
  • DBCO-PEG4-Maleimide,Dibenzocyclooctyne-PEG4-maleimide
  • 1H-Pyrrole-1-propanamide, N-[19-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-15-oxo-3,6,9,12-tetraoxa-16-azanondec-1-yl]-2,5-dihydro-2,5-dioxo-
  • DBCO-dPEG??-MAL
  • N-(3-(11,12-dihydrodibenzo[b,f]azocin-5(6H)-yl)propyl)-1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-3,6,9,12-tetraoxapentadecan-15-amide
  • [DBCO-PEG-MAL] α-Dibenzocyclooctyne-ω-maleimide poly(ethylene glycol)
  • DBCO-NHCO-PEG4-BMPA
  • 1H-Pyrrole-1-propanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-15,19-dioxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]-2,5-dihydro-2,5-dioxo-
  • DBCO-NHCO-PEG4-NH-Maleimide
  • DBCO-PEG4-MAL
  • DBCO-PEG4-Maleimide?Chemical Structure
  • 1480516-75-3
  • C36H42N4O9
  • PROTAC LINKER