4-Amino-5-imidazolecarboxamide hydrochloride

Product Name: 4-Amino-5-imidazolecarboxamide hydrochloride
CAS No.: 72-40-2
Chemical Name: 4-Amino-5-imidazolecarboxamide hydrochloride
Synonyms: AICA;AICA HCL;AIC .cntdot. HCl;AICA HYDROCHLORIDE;TIMTEC-BB SBB003938;5-Amino-1H-imidazoL;LABOTEST-BB LT00440910;e-4-carboxamide hydrochL;Temozolomide intermediate;Dacarbazine EP Impurity B
CBNumber: CB5300628
Molecular Formula: C4H7ClN4O
Formula Weight: 162.58
MOL File: 72-40-2.mol

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4-Amino-5-imidazolecarboxamide hydrochloride Property

Melting point:: 250-252 °C (dec.)(lit.)
storage temp.: 2-8°C
solubility: water: soluble50mg/mL, clear, light yellow
form: Crystals or Crystalline Powder
color: White
Water Solubility: SOLUBLE
Sensitive: Hygroscopic
BRN: 3701645
Stability:: Hygroscopic
InChI: InChI=1S/C4H6N4O.ClH/c5-3-2(4(6)9)7-1-8-3;/h1H,5H2,(H2,6,9)(H,7,8);1H
InChIKey: MXCUYSMIELHIQL-UHFFFAOYSA-N
SMILES: C1(N=CNC=1N)C(=O)N.Cl
CAS DataBase Reference: 72-40-2(CAS DataBase Reference)
NIST Chemistry Reference: Imidazole-4(5)-carboxamide, 5-(4)-amino-, hydrochloride(72-40-2)
EPA Substance Registry System: 1H-Imidazole-4-carboxamide, 5-amino-, monohydrochloride (72-40-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
RTECS: NI3911000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29332990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 164968
Product name: 5-Amino-4-imidazolecarboxamide hydrochloride
Purity: 98%
Packaging: 5g
Price: $23.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2304
Product name: Dacarbazine Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 100MG
Price: $534
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1162320
Product name: Dacarbazine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $1380
Updated: 2024/03/01

TCI Chemical

Product number: A1175
Product name: 5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $55
Updated: 2024/03/01

TCI Chemical

Product number: A1175
Product name: 5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $203
Updated: 2024/03/01

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4-Amino-5-imidazolecarboxamide hydrochloride Chemical Properties,Usage,Production

Chemical Properties

very slightly beige fine powder

Uses

5-Amino-4-imidazolecarboxamide hydrochloride was used in the synthesis of heterocyclic compounds such as guanine, purines and pyrimidines.

General Description

Corrosion inhibition and adsorption characteristics of 5-amino-4-imidazolecarboxamide hydrochloride on aluminum in 1M HCl has been investigated.

Synthesis

47 g of sodium nitrite was dissolved in 1.2 liters of water; The solution was cooled to 0° C. 100 g of 5-aminoimidazole-4 carboxamide was dissolved in a solution of hydrochloric acid (80 ml of 36% HCL in 720 ml water) with stirring. The resultant 5-aminoimidazole-4 carboxamide hydrochloride solution was added slowly, drop-wise, over 20-30 minutes at 0-5° C. After the addition was completed, the reaction mixture was stirred for 10 minutes and filtered. The solid obtained was suspended in 400 ml DM water and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. The obtained solid was suspended in 500 ml of THF and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. Finally, the solid was dried at 45° C. to afford 4-Amino-5-imidazolecarboxamide hydrochloride.

Purification Methods

Recrystallise the hydrochloride from EtOH. [Kuroda & Hakko JEst(1) Est(2)Heterocycl Chem 30 593 1993, Alhede et al. J Org Chem 56 2139 1991, Cheru et al. Heterocycles 24 1133 1992, Beilstein 25 II 221, 25 III/IV 4329.]

4-Amino-5-imidazolecarboxamide hydrochloride Preparation Products And Raw materials

Raw materials

carbanilic acid Acetamide

Preparation Products

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4-Amino-5-imidazolecarboxamide hydrochloride Suppliers

Americas 1 Belgium 2 Canada 1 China 312 Europe 3 Germany 6 India 41 Italy 1 Japan 5 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 2 United Kingdom 16 United States 44 Global 439

Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.

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Hunan Kaimir Biotechnology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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INTATRADE GmbH

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Country: Germany
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Alfa Aesar

Tel: 400-6106006
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View Lastest Price from 4-Amino-5-imidazolecarboxamide hydrochloride manufacturers

airuikechemical co., ltd.

Product: 4-Amino-5-imidazole carboxamide hydrochloride 72-40-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-07

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Amino-5-Imidazolecarboxamide Hydrochloride 72-40-2
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-23

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 4-Amino-5-imidazolecarboxamide hydrochloride 72-40-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.5%
Supply Ability: 500kg
Release date: 2022-09-30

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AICA

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TIMTEC-BB SBB003938

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LABOTEST-BB LT00440910

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5-Aminoimidazol-4-carboxamide, hydrochloride

5-Imidazolecarboxamide, 4-amino-, hydrochloride

AIC .cntdot. HCl

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4-Amino-5-carboxamido imidazole hydrochloride

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e-4-carboxamide hydrochL