4-Chloro-3-fluoroaniline
Uses- Product Name
- 4-Chloro-3-fluoroaniline
- CAS No.
- 367-22-6
- Chemical Name
- 4-Chloro-3-fluoroaniline
- Synonyms
- BUTTPARK 44\01-97;Gefitinib Impurity 96;Fluoro-4-chloroaniline;4-Chloro-3-fluoroanline;3-FLUORO-4-CHLOROANILINE;4-CHLORO-3-FLUOROANILINE;4-Chloro-3-fluoroaniline98%;4-Chloro-3-fluoroaniline >4-Chloro-3-fluoroaniline 98%;4-chloro-3-fluorobenzenaMine
- CBNumber
- CB5343050
- Molecular Formula
- C6H5ClFN
- Formula Weight
- 145.56
- MOL File
- 367-22-6.mol
4-Chloro-3-fluoroaniline Property
- Melting point:
- 61
- Boiling point:
- 226°C(lit.)
- Density
- 1.349±0.06 g/cm3(Predicted)
- Flash point:
- 60 - 62°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.94±0.10(Predicted)
- color
- White to Gray to Red
- BRN
- 2716278
- InChI
- InChI=1S/C6H5ClFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
- InChIKey
- ACMJJQYSPUPMPN-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(Cl)C(F)=C1
- CAS DataBase Reference
- 367-22-6(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39-63-45-38
- RIDADR
- UN2811
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 779970
- Product name
- 4-Chloro-3-fluoroaniline
- Purity
- ≥97.0% (GC)
- Packaging
- 5g
- Price
- $66.4
- Updated
- 2023/06/20
- Product number
- C2512
- Product name
- 4-Chloro-3-fluoroaniline
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- C2512
- Product name
- 4-Chloro-3-fluoroaniline
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $234
- Updated
- 2025/07/31
- Product number
- C367100
- Product name
- 4-Chloro-3-fluoroaniline
- Packaging
- 25g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 3630-7-43
- Product name
- 4-Chloro-3-fluoroaniline
- Purity
- 98%
- Packaging
- 2g
- Price
- $10
- Updated
- 2021/12/16
4-Chloro-3-fluoroaniline Chemical Properties,Usage,Production
Uses
4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib.
Chemical Properties
White to light yellow solid
Uses
4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate
Synthesis
372-19-0
367-22-6
1. A CHCl3 (20.0 mL) solution of N-chlorosuccinimide (NCS) was added slowly and dropwise to a stirred CHCl3 (30.0 mL) solution of 3-fluoroaniline (1.11 g, 10.0 mmol) at 0 °C. 2. The reaction mixture was stirred continuously at 0 °C for 42 hours. 3. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in Et2O. 4. The mixture was washed with water and subsequently dried with MgSO4. 5. After concentration under reduced pressure, the mixture was purified by rapid chromatography on silica gel, using EtOAc/hexane as eluent, to afford 4-chloro-3-fluoroaniline (259.4 g, 18% yield) as a crystalline solid. 6. To a stirred solution of the above 4-chloro-3-fluoroaniline (259.4 mg, 1.78 mmol) in THF (8.9 mL) was added ethyl chloroacetate (237.3 μL, 2.14 mmol) and Et3N (296.6 μL, 2.14 mmol) sequentially at 0 °C. 7. The mixture was stirred at room temperature for 12 hours. 8. After filtration to remove the precipitate, the filtrate was concentrated under reduced pressure. 9. The residue was dissolved in EtOAc, washed sequentially with 1.0 M HCl, saturated NaHCO3 solution and brine, and then dried with MgSO4. 10. After concentration under pressure, 3-fluoro-4-chloroaniline 6a (435.2 mg, 99% yield) was obtained as brown crystals, which could be used without further purification.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 11, p. 3282 - 3285
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 9, p. 2518 - 2526
[3] Patent: EP1342717, 2003, A1
[4] Patent: US2003/236267, 2003, A1. Location in patent: Page 30
4-Chloro-3-fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-3-fluoroaniline Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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- Americas
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View Lastest Price from 4-Chloro-3-fluoroaniline manufacturers
- Product
- 4-Chloro-3-fluoroaniline 367-22-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 4-Chloro-3-fluoroaniline 367-22-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-06-18
- Product
- 4-Chloro-3-fluoroaniline 367-22-6
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08