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Boc-Hyp-OH

Product Name
Boc-Hyp-OH
CAS No.
13726-69-7
Chemical Name
Boc-Hyp-OH
Synonyms
(2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;BOC-HYP-OH;BOC-HYP;BOC-L-HYP-OH;N-BOC-L-HYDROXYPROLINE;(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;(2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylic Acid;N-ter;Teneint-E;BOC-TRANS-HYP-OH
CBNumber
CB5411793
Molecular Formula
C10H17NO5
Formula Weight
231.25
MOL File
13726-69-7.mol
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Boc-Hyp-OH Property

Melting point:
123-127 °C(lit.)
alpha 
-78 º (in H2O)
Boiling point:
390.9±42.0 °C(Predicted)
Density 
1.312±0.06 g/cm3(Predicted)
refractive index 
-68 ° (C=1, MeOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.80±0.40(Predicted)
form 
Powder
color 
White to off-white
optical activity
[α]20/D 53.5±2°, c = 1% in DMF
Water Solubility 
very faint turbidity
BRN 
4295484
InChIKey
BENKAPCDIOILGV-RQJHMYQMSA-N
CAS DataBase Reference
13726-69-7(CAS DataBase Reference)
EPA Substance Registry System
(2S,4R)-1-tert-Butyl 4-hydroxy-1,2-pyrrolidinecarboxylate (13726-69-7)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2933 99 80
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53026
Product name
Boc-Hyp-OH (cryst)
Purity
Novabiochem?
Packaging
25g
Price
$344
Updated
2024/03/01
Sigma-Aldrich
Product number
8.53026
Product name
Boc-Hyp-OH (cryst)
Purity
Novabiochem?
Packaging
100g
Price
$1030
Updated
2024/03/01
Sigma-Aldrich
Product number
15544
Product name
Boc-Hyp-OH
Purity
≥98.0% (TLC)
Packaging
5g
Price
$36.6
Updated
2024/03/01
Sigma-Aldrich
Product number
15544
Product name
Boc-Hyp-OH
Purity
≥98.0% (TLC)
Packaging
25g
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
B1635
Product name
trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline
Purity
>98.0%(T)
Packaging
5g
Price
$18
Updated
2024/03/01
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Boc-Hyp-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-Hyp-OH is used in the preparation of hydroxyproline derivatives. It is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Biological Activity

Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-Hyp-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Hyp-OH Suppliers

Americas 1 Belgium 2 Canada 1 China 367 Europe 3 France 3 Germany 8 Hungary 1 India 25 Japan 5 South Korea 1 Switzerland 4 The Netherlands 1 United Kingdom 13 United States 57 Global 492
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View Lastest Price from Boc-Hyp-OH manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-L-Hydroxyproline 13726-69-7
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%HPLC
Supply Ability
10 Tons
Release date
2021-06-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-Hyp-OH 13726-69-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-24
Henan Bao Enluo International TradeCo.，LTD
Product
Boc-L-Hydroxyproline 13726-69-7
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-07-20

13726-69-7, Boc-Hyp-OHRelated Search:

L-Hydroxyproline BOC-D-PHE-OSU Boc-D-Valine 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Methyl N-(tert-butoxycarbonyl)-L-threoninate Boc-L-serine methyl ester BOC-GUANIDINE BOC-L-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,BOC-HYP-OME / BOC-L-HYDROXYPROLINE METHYL ESTER BOC-HYP(BZL)-OH 1-Boc-L-hydroxyproline ethyl ester N-Boc-trans-4-tosyloxy-L-proline methyl ester (2S, 4R)-BOC-GAMMA-MSO-PROLINE METHYL ESTER Boc-Hyp-OH BOC-CIS-HYDROXYPROLINE-OME L-Proline (2S,4R)-BOC-4-(2-NAPHTHYLMETHOXY)-PYRROLIDINE-2-CARBOXYLIC ACID BOC-HYP-OH DCHA (2S,4R)-BOC-4-(2-NAPHTHYLOXY)-PYRROLIDINE-2-CARBOXYLIC ACID

  • (2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
  • (2S,4R)-N-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic Acid
  • Boc-(2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylic Acid
  • N-ter
  • N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-proline ,98%
  • Boc-L-trans-hydroxyproline(Boc-trans-Hyp-OH) ,98.5%(HPLC)
  • 1,2-Pyrrolidinedicarboxylicacid,4-hydroxy-,1-(1,1-diMethylethyl)ester,(2S,4R)-
  • (2S)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
  • trans-N-Boc-4-hydroxy-L-proline trans-Boc-Hyp-OH
  • (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester
  • (2S,4R)-1-(tertbutoxycarbonyl-4-hydroxypyrrolidine acid
  • Boc-Hyp-OH, >=98.0%
  • <i>trans</i>-N-(<i>tert-</i>Butoxycarbonyl)-4-hydroxy-L-proline
  • N-Boc-(2S,4R)-4-hydroxyproline
  • BOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
  • BOC-L-HYDROXYPROLINE
  • BOC-L-HYP-OH
  • BOC-L-4-HYDROXYPROLINE
  • BOC-HYDROXYPROLINE
  • BOC-HYP-OH
  • BOC-TRANS-HYP-OH
  • BOC-TRANS-4-HYDROXY-L-PROLINE
  • BOC-L-T-4-HYDROXYPROLINE
  • BOC-L-TRANS-4-HYDROXYPROLINE
  • Boc-L-trans-4-hydroxyproline≥ 99% (Assay)
  • Boc-Hyp-OH (cryst) Novabiochem
  • Boc-Hyp-OH >=98.0% (TLC)
  • (2S,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
  • RARECHEM EM WB 0136
  • N-T-BOC-TRANS-4-HYDROXY-L-PROLINE
  • N-(TERT-BUTOXYCARBONYL)-L-4-HYDROXYPROLINE
  • N-TERT-BUTOXYCARBONYL-L-HYDROXYPROLINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-HYDROXYPROLINE
  • N-ALPHA-T-BUTOXYCARBONYL-TRANS-4-HYDROXY-L-PROLINE
  • （2S，4R)-1-（tertbutoxycarbonyl）-4-hydroxypyrrolidine carboxylic acid
  • (Tert-Butoxy)Carbonyl Hyp-OH (Hyp of Animal Origin)
  • (Tert-Butoxy)Carbonyl Hyp-OH (Hyp of Non-Animal Origin)
  • Teneint-E
  • (4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline
  • BOC-HYPOZANTHINE extrapure
  • Boc-L-hydroxyproline, trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline
  • trans-Boc-Hyp-OH
  • trans-N-Boc-4-hydroxy-L-proline
  • 1-[(tert-Butoxy)carbonyl]-4-hydroxy-L-proline
  • (2S,4R)-N-Boc-trans-4-hydroxy-L-proline
  • (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, N-BOC protected 97%
  • N-ALPHA-T-BOC-TRANS-4-HYDROXY-L-PROLINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-HYDROXYPROLINE
  • N-ALPHA-T-BOC-L-HYDROXYPROLINE
  • N-ALPHA-T-BOC-L-TRANS-4-HYDROXYPROLINE
  • N-BOC-TRANS-4-HYDROXY-L-PROLINE
  • N-BOC-L-4-HYDROXYPROLINE
  • N-BOC-L-TRANS-4-HYDROXYPROLINE
  • N-BOC-4-HYDROXY-L-PROLINE
  • TRANS-N-(TERT-BUTOXYCARBONYL)-4-HYDROXY-L-PROLINE
  • Butoxycarbonylhydroxypyroline
  • Boc-4-hydroxy-L-proline
  • TRANS-N-(TERT-BUTOXYCARBONYL)-4-HYDROXY-