ChemicalBook > CAS DataBase List > Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
- Product Name
- Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
- CAS No.
- 607366-20-1
- Chemical Name
- Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
- Synonyms
- FMOC-DAP(IVDDE)-OH;FMOC-DPR(IVDDE)-OH;FMOC-L-DAP(IVDDE)-OH;N-α-Fmoc-N-β-1-(4,4-dimethyl-2,6-dioxocyclohex-1;Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine;3-[1-(4,4-DiMethyl-2,6-dioxocyclohexylidene)-3-MethylbutylaMino]-FMoc-L-alanine, 95%;Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine USP/EP/BP;FMoc-Nβ-(4,4-diMethyl-2,6-dioxocyclohex-1-ylidene)-3-Methylbutyl-L-2,3-diaMinopropionic acid;Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic acid;Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic acid
- CBNumber
- CB5413560
- Molecular Formula
- C31H36N2O6
- Formula Weight
- 532.63
- MOL File
- 607366-20-1.mol
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Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Property
- Boiling point:
- 733.7±60.0 °C(Predicted)
- Density
- 1.221
- storage temp.
- Store at -15°C to -25°C.
- pka
- 3.47±0.10(Predicted)
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Safety
- HS Code
- 2924297099
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 8.52083
- Product name
- Fmoc-Dpr(ivDde)-OH
- Purity
- Novabiochem?
- Packaging
- 1G
- Price
- $153
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 8.52083
- Product name
- Fmoc-Dpr(ivDde)-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $713
- Updated
- 2024/03/01
TRC
- Product number
- F621080
- Product name
- N-α-Fmoc-N-β-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionicAcid
- Packaging
- 1g
- Price
- $335
- Updated
- 2021/12/16
TRC
- Product number
- F621080
- Product name
- N-α-Fmoc-N-β-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionicAcid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
Chem-Impex
- Product number
- 07105
- Product name
- Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionicacid,98-100%(Assaybytitration)
- Purity
- 98-100%(Assaybytitration)
- Packaging
- 250MG
- Price
- $95.76
- Updated
- 2021/12/16
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Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Chemical Properties,Usage,Production
Uses
N-alpha-Fmoc-N-beta-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic Acid is used in the synthesis of phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates as Src kinase inhibitors. It is also used to prepare peptidomimetic ligands for α4β1 integrin on Jurkat T-leukemia cells.
General Description
This orthogonally-protected diaminopropionic acid derivative is based on the hindered Dde variant ivDde. The side-chain ivDde group is considerably more stable to piperidine than Dde and is less prone to migrate from protected to unprotected side-chains [1]. However, migration from side-chain to the unprotected α-amino group of Dpr is unavoidable [2]. This side-reaction can, however, be minimized by the appropriate choice of coupling method for the subsequent residue, see [3].
When removing ivDde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [4].
The product number for this product was previously 04-12-1195.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Preparation Products And Raw materials
Raw materials
Preparation Products
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Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Suppliers
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