2-BROMO-4-HYDROXYMETHYLTHIAZOLE

Product Name: 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
CAS No.: 5198-86-7
Chemical Name: 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
Synonyms: 2-BROMOTHIAZOLE-4-METHANOL;2-Bromo-4-thiazolemethanol;2-Bromo-4-thiazolylmethanol;4-ThiazoleMethanol,2-broMo-;(2-bromothiazol-4-yl)methanol;2-BROMO-4-HYDROXYMETHYLTHIAZOLE;(2-bromo-1,3-thiazol-4-yl)methanol;(2-BROMO-1,3-THIAZOLE-4-YL)METHANOL;2-Bromo-4-(hydroxymethyl)-1,3-thiazole;2-Bromo-4-(hydroxymethyl)-1,3-thiazole97%
CBNumber: CB5463116
Molecular Formula: C4H4BrNOS
Formula Weight: 194.05
MOL File: 5198-86-7.mol

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2-BROMO-4-HYDROXYMETHYLTHIAZOLE Property

Boiling point:: 56 °C(Press: 10 Torr)
Density: 1.899±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: liquid
pka: 12.82±0.10(Predicted)
color: Light yellow
CAS DataBase Reference: 5198-86-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
Hazard Note: Irritant/Keep Cold
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00394
Product name: 2-Bromo-4-hydroxymethylthiazole
Packaging: 1g
Price: $356
Updated: 2025/07/31

TRC

Product number: B688383
Product name: 2-Bromothiazole-4-methanol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B688383
Product name: 2-Bromothiazole-4-methanol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H01-9-X0
Product name: 2-Bromo-4-(hydroxymethyl)-1,3-thiazole
Purity: 97.0%
Packaging: 1g
Price: $53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB53501
Product name: (2-Bromothiazol-4-yl)methanol
Packaging: 500mg
Price: $70
Updated: 2021/12/16

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2-BROMO-4-HYDROXYMETHYLTHIAZOLE Chemical Properties,Usage,Production

Synthesis

100367-77-9

5198-86-7

General procedure for the synthesis of 2-bromothiazole-4-methanol from ethyl 2-bromothiazole-4-carboxylate: In a dry reaction flask, ethyl 2-bromothiazole-4-carboxylate (10.0 g, 42.4 mmol, 1 eq.) was dissolved in tetrahydrofuran (200 mL), and sodium borohydride (4.81 g, 127 mmol, 3 eq.), lithium chloride (5.4 g, 130 mmol, 3 eq.), and water (40 mL) were added in sequence. 130 mmol, 3 equiv) and water (40 mL). The resulting two-phase mixture was stirred vigorously at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent 20% ethyl acetate/hexane) to confirm complete consumption of the raw materials. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (200 mL), diluted with the addition of ethyl acetate (200 mL), and the organic and aqueous layers were separated. The aqueous layer was extracted with ethyl acetate (100 mL), the organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-bromothiazole-4-methanol as a yellow semi-solid (7.82 g, 95% yield). The Rf value of the thin-layer chromatography was 0.2 (silica gel plate, unfolding agent was 20% ethyl acetate/hexane); the 1H NMR and 13C NMR spectra of the product were consistent with those reported in the literature (Wipf and Wang, 2007).

References

[1] Patent: WO2015/57585, 2015, A1. Location in patent: Page/Page column 27; 28
[2] Patent: CN104478866, 2017, B. Location in patent: Paragraph 0281; 0283; 0284
[3] Patent: CN104478869, 2017, B. Location in patent: Paragraph 0142; 0143; 0144; 0145
[4] Patent: WO2017/184624, 2017, A1. Location in patent: Page/Page column 185; 186
[5] Journal of Organic Chemistry, 2016, vol. 81, # 21, p. 10302 - 10320

2-BROMO-4-HYDROXYMETHYLTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4-HYDROXYMETHYLTHIAZOLE Suppliers

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View Lastest Price from 2-BROMO-4-HYDROXYMETHYLTHIAZOLE manufacturers

Career Henan Chemical Co

Product: 2-BROMO-4-HYDROXYMETHYLTHIAZOLE 5198-86-7
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

5198-86-7, 2-BROMO-4-HYDROXYMETHYLTHIAZOLERelated Search:

(2-METHYL-1,3-THIAZOL-4-YL)METHANOL 2-Chloro-4-thiazole-Methanol 2-Bromo-4-thiazolecarboxylic acid 2-BROMO-4-HYDROXYMETHYLTHIAZOLE Ethyl 2-bromothiazole-4-carboxylate 2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER METHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE 2-Bromothiazole 4-Hydroxymethylthiazole 2,4-Dibromothiazole-5-methanol 2-BROMO-5-HYDROXYMETHYLTHIAZOLE 2,5-DIBROMO-4-(HYDROXYMETHYL)THIAZOLE Methyl 2-bromo-5-isopropyl-1,3-thiazole-4-carboxylate ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE 2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID 2,5-DIBROMOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER 2-BROMO-5-ISOPROPYLTHIAZOLE-4-CARBOXYLATE METHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE

2-BROMOTHIAZOLE-4-METHANOL

(2-BROMO-1,3-THIAZOLE-4-YL)METHANOL

2-BROMO-4-HYDROXYMETHYLTHIAZOLE

2-Bromo-4-(hydroxymethyl)-1,3-thiazole

2-Bromo-4-(hydroxymethyl)-1,3-thiazole 97%

(2-bromothiazol-4-yl)methanol

(2-bromo-1,3-thiazol-4-yl)methanol

(2-bromo-1,3-thiazol-4-yl)methanol(SALTDATA: HCl)

4-ThiazoleMethanol,2-broMo-

2-Bromo-4-thiazolylmethanol

2-Bromo-4-(hydroxymethyl)-1,3-thiazole97%

2-Bromo-4-thiazolemethanol

5198-86-7

C4H4BrNOS

blocks

Bromides

Thiazoles

API intermediates