pollution
ChemicalBook > CAS DataBase List > 2,4-Dihydroxybenzophenone

2,4-Dihydroxybenzophenone

pollution
Product Name
2,4-Dihydroxybenzophenone
CAS No.
131-56-6
Chemical Name
2,4-Dihydroxybenzophenone
Synonyms
BP-1;UV-0;BENZOPHENONE-1;Uv 12;BENZORESORCINOL;uv12;4-BENZORESORCINOL;hhb;uf1;Uf 1
CBNumber
CB5475441
Molecular Formula
C13H10O3
Formula Weight
214.22
MOL File
131-56-6.mol
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2,4-Dihydroxybenzophenone Property

Melting point:
144.5-147 °C(lit.)
Boiling point:
194 °C (1 mmHg)
Density 
1,32 g/cm3
vapor pressure 
0Pa at 25℃
refractive index 
1.5090 (estimate)
Flash point:
125 °C
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly, Heated), Ethanol (Slightly, Heated)
pka
7.72±0.35(Predicted)
form 
Crystalline Powder
color 
Yellow
PH
5 (10g/l, H2O, 20℃)(slurry)
Water Solubility 
insoluble
Merck 
14,1106
BRN 
1311566
InChIKey
ZXDDPOHVAMWLBH-UHFFFAOYSA-N
LogP
2.964 at 25℃
CAS DataBase Reference
131-56-6(CAS DataBase Reference)
NIST Chemistry Reference
Methanone, (2,4-dihydroxyphenyl)phenyl-(131-56-6)
EPA Substance Registry System
Methanone, (2,4-dihydroxyphenyl)phenyl- (131-56-6)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36-36/37/38-61
Safety Statements 
26-37/39-45-53
WGK Germany 
2
RTECS 
DJ0700000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29145000
Hazardous Substances Data
131-56-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SRP5162
Product name
4EBP1, His tagged human
Purity
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Packaging
50μG
Price
$349
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18652
Product name
2,4-Dihydroxybenzophenone
Purity
for synthesis
Packaging
250g
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
126217
Product name
2,4-Dihydroxybenzophenone
Purity
99%
Packaging
100g
Price
$45.3
Updated
2024/03/01
TCI Chemical
Product number
D0573
Product name
2,4-Dihydroxybenzophenone
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
D0573
Product name
2,4-Dihydroxybenzophenone
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$153
Updated
2024/03/01
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2,4-Dihydroxybenzophenone Chemical Properties,Usage,Production

pollution

Benzophenones (BPs), as UV filters, are widely utilized in personal care products such as sunscreen, body lotion and plastic products. 2,4-Dihydroxybenzophenone (BP-1) is a representative type of BP that has attracted wide attention owing to the high residues in the aquatic environment. According to previous studies, this compound can enter the aquatic environment through recreational water activities or incomplete removal in wastewater treatment plants (WWTPs). For example, BP-1 has been widely detected in seawater, groundwater, river water and WWTP effluents in Spain at concentrations ranging from 4.2 ng/L to 722.0 ng/L. More seriously, because of extensive human exposure through plastic products and sunscreen cosmetics, BP-1 has been detected in human urine, blood and milk[1].

Description

2,4-Dihydroxybenzophenone (DHP) is an organic compound derived from Garcinia xanthochymus, but there have been no reports on its biochemical functions and bioavailability. 2,4-dihydroxybenzophenone has been prepared by reacting resorcinol with benzoyl chloride or benzoic acid under anhydrous conditions in the presence of Friedel-Crafts catalysts such as AlCl3 or ZnCl2[1].

Chemical Properties

yellow crystalline powder

Uses

Novel mordent and disperse azo dyes were prepared by the coupling of various diazo solutions of aromatic amines with 2, 4-dihydroxybenzophenone. The ultraviolet absorbing monomers were synthesized by reaction of 2, 4-dihydroxybenzophenone with glycidyl acrylate and glycidyl methacrylate. Two new polymerizable stabilizers, 4-benzoyl-2-(α-piperidino-2-chlorobenzyl)-3-hydroxyphenyl acrylate (BPBHA) and corresponding methacrylate (BPBHMA), were synthesized and characterized from 2,4-Dihydroxybenzophenone. a polymerizable UV-stabilizer, 2-hydroxy-4-(3-methacryloxy-2-hydroxylpropoxy) benzophenone (BPMA), was synthesized using 2, 4-dihydroxybenzophenone (UV-0) and glycidyl methacrylate (GMA).

Uses

2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.

Uses

Ultraviolet light absorber, especially in paints and plastics.

Definition

ChEBI: 2,4-Dihydroxybenzophenone is a member of benzophenones.

Preparation

Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).

Biological Activity

2,4-Dihydroxybenzophenone has potential effects on the stimulation of osteoblast differentiation and mitigate PDS-induced osteoporosisthrough the activation of the β-catenin pathway. Moreover, 2,4-Dihydroxybenzophenone demonstrated a capacity to enhance the expression of crucial osteogenic markers, including RUNX2, OSX, and ALP[2].

Contact allergens

BZP-1 is used, for example, in paints, plastics, and nail varnishes.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicology

As a persistent and bioaccumulative compound, 2,4-Dihydroxybenzophenone (BP-1) exhibits estrogenic activity or anti-androgenic activity in vitro, which could pose potential risks to the ecological environment and human health. At present, there are a large amount of reports that concentrated on the biotoxicity of BP-1, mainly focusing on its endocrine disrupting effects and genetic toxicity. Endocrine-toxicological studies have shown that the toxicity of BP-1 is five times that of bisphenol A (BPA)[2].

Purification Methods

Recrystallise it from MeOH. [Beilstein 8 IV 2442.]

References

[1] Mengting Zou . “Effective degradation of 2,4-dihydroxybenzophenone by zero–valent iron powder (Fe0)-activated persulfate in aqueous solution: Kinetic study, product identification and theoretical calculations.” Science of the Total Environment 771 (2021): Article 144743.
[2] Mirissa Hewage Dumindu Kavinda and & Gi-Young Kim*. “2,4′-Dihydroxybenzophenone Exerts Bone Formation and Antiosteoporotic Activity by Stimulating the β-Catenin Signaling Pathway.” ACS Pharmacology and Translational Science 7 2 (2024): 395–405.

2,4-Dihydroxybenzophenone Preparation Products And Raw materials

Raw materials

Phenol Resorcinol Benzotrichloride Benzoyl chloride

Preparation Products

2-(4-Benzoyl-3-hydroxyphenoxy)ethyl acrylate Octabenzone Fluotrimazol 2-METHYL-ACRYLIC ACID-2-(4-BENZOYL-3-HYDROXY-PHENOXY)-ETHYL ESTER
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View Lastest Price from 2,4-Dihydroxybenzophenone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
UV ABSORBER UV-0 131-56-6
Price
US $80.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-06-04
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
UV Absorber Benzophenone-1 UV-0 131-56-6
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2,4-Dihydroxybenzophenone 131-56-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-11-04

131-56-6, 2,4-DihydroxybenzophenoneRelated Search:

Ethyl 4-[[(methylphenylamino)methylene]amino]benzoate Bis(4-fluorophenyl)-methanone 2-Phenylbenzimidazole-5-sulfonic acid UV Absorber 326 (3,4-Diaminophenyl)phenylmethanone 4,4'-Dimethylbenzophenone UV-329 2,4-Difluorobenzophenone Benzophenone Diphenyl ether Octabenzone Benzophenone imine Oxybenzone Drometrizole PHENYL VALERATE Phenyl salicylate Acetaldehyde 2,2-Bis(hydroxymethyl)propionic acid

  • (2,4-dihydroxyphenyl)phenyl-methanon
  • (2,4-Dihydroxyphenyl)-phenylmethanon (2,4-dihydroxybenzophenon)
  • 2,4-DHBP
  • 2,4-Dihydroxtbenzophenone
  • 2,4-Dihydroxybenzofenon
  • 2,4-dihydroxy-benzophenon
  • 2,4-dihydroxydiphenylketone
  • Advastab 48
  • 4-BENZORESORCINOL
  • 4-BENZOYLRESORCINOL
  • 2,4-DIHYDROXYBENZOPHENONE
  • (2,4-DIHYDROXY-PHENYL)-PHENYL-METHANONE
  • BP-1
  • UV-0
  • BENZOPHENONE-1
  • BENZORESORCINOL
  • DIHYDROXYBENZOPHENONE(2,4-)
  • SYNSORB
  • 2,4-Dihydroxydiphenyl keton
  • UV ABSORBER DHB
  • Benzophenone-1(2,4-Dihydroxyben-Zophenone)
  • 2,4-Dihydroxybenzophenone(UV-0)
  • advastab48
  • Benzophenone, 2,4-dihydroxy-
  • Dastib 263
  • dastib263
  • Eastman inhibitor dhpb
  • eastmaninhibitordhpb
  • hhb
  • Inhibitor dhbp
  • inhibitordhbp
  • Quinsorb 010
  • quinsorb010
  • Resbenzophenone
  • Syntase 100
  • syntase100
  • Uf 1
  • uf1
  • UltravioletAbsorberUV-0
  • USAF DO-28
  • USAF ND-54
  • usafdo-28
  • usafnd-54
  • Uv 12
  • uv12
  • Uvinol 400
  • Uvinul 400
  • uvinul400
  • Uvistat 12
  • uvistat12
  • Uv absorber BP-1(UV-0)
  • UV BP1
  • Methanone, (2,4-dihydroxyphenyl)phenyl-
  • 2,4-Dihydroxy Benzophenone ( Benzophenone-1)
  • Ultravioletabsorber
  • BENZOPHENE-1
  • 2,4-DIHYDROXYBENZOPHENONE 99+%
  • Recombinant Human BP-1