2-Acetyl-6-bromopyridine
- Product Name
- 2-Acetyl-6-bromopyridine
- CAS No.
- 49669-13-8
- Chemical Name
- 2-Acetyl-6-bromopyridine
- Synonyms
- 1-(6-Bromopyridin-2-yl)ethan-1-one;1-(6-Bromopyridine;2-Bromo-6-Acetylpyridine;2-Acetyl-6-bromopyridine;2- acetyl-6-pyridyl broMide;2-Acetyl-6-bromopyridine>2-ACETYL-6-BROMOPYRIDINE 97;2-Acetyl-6-bromopyridine 97%;1-(6-bromo-2-pyridyl)ethanone;1-(6-Brompyridin-2-yl)ethanon
- CBNumber
- CB5505252
- Molecular Formula
- C7H6BrNO
- Formula Weight
- 200.03
- MOL File
- 49669-13-8.mol
2-Acetyl-6-bromopyridine Property
- Melting point:
- 51-55 °C (lit.)
- Boiling point:
- 271.2±25.0 °C(Predicted)
- Density
- 1.534±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in methanol.
- form
- Solid
- pka
- 0.28±0.10(Predicted)
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C7H6BrNO/c1-5(10)6-3-2-4-7(8)9-6/h2-4H,1H3
- InChIKey
- RUJTWTUYVOEEFW-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=NC(Br)=CC=C1)C
- CAS DataBase Reference
- 49669-13-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 597872
- Product name
- 2-Acetyl-6-bromopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $20.8
- Updated
- 2025/07/31
- Product number
- 597872
- Product name
- 2-Acetyl-6-bromopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $197
- Updated
- 2025/07/31
- Product number
- A2404
- Product name
- 2-Acetyl-6-bromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- A2404
- Product name
- 2-Acetyl-6-bromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $123
- Updated
- 2025/07/31
- Product number
- A168505
- Product name
- 2-Acetyl-6-bromopyridine
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
2-Acetyl-6-bromopyridine Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
2-Acetyl-6-bromopyridine, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as OLED intermediate.
Synthesis
626-05-1
127-19-5
49669-13-8
General procedure for the synthesis of 2-acetyl-6-bromopyridine from 2,6-dibromopyridine and N,N-dimethylacetamide: 2,6-dibromopyridine (10.0 g, 42.2 mmol) was placed in a dry reaction flask. To ensure an inert atmosphere, the reaction flask was evacuated and replaced with nitrogen and repeated three times. 150 mL of anhydrous diethyl ether was added to the reaction flask and after cooling to -78 °C, n-butyllithium solution (17.7 mL, 44.3 mmol, 2.5 M in n-hexane) was slowly added dropwise and the color of the mixture was observed to change from clear to yellowish brown. Maintained at -78 °C and stirred continuously for 30 min. Subsequently, N,N-dimethylacetamide (4.7 mL, 50.7 mmol) was added slowly and the reaction was maintained at -78 °C for 3 hours. Upon completion of the reaction, the temperature was slowly increased to 20 °C, at which point the color of the mixture changed to a turbid gray. The reaction was quenched by the slow addition of deionized water. The solvent was removed by rotary evaporation and the residue was washed several times with ethyl acetate and saturated sodium chloride solution, the organic layers were combined and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:20) and then recrystallized in a mixture of dichloromethane and n-hexane solvent (dichloromethane/hexane=1:20) to give a white crystalline product (6.80 g, 81% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.97 (dd, J=7.0,1.6Hz, 1H), 7.68 (t, J=7.8Hz, 1H), 7.64 (dd, J=8.0,1.2Hz, 1H), 2.69 (s, 3H), and was confirmed as the target compound 2-acetyl-6-bromopyridine.
References
[1] Organometallics, 2016, vol. 35, # 2, p. 198 - 206
[2] Journal of Heterocyclic Chemistry, 2009, vol. 46, # 1, p. 116 - 118
[3] Patent: US9219237, 2015, B1. Location in patent: Page/Page column 7
[4] Journal of Organic Chemistry, 2006, vol. 71, # 1, p. 167 - 175
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6763 - 6770
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View Lastest Price from 2-Acetyl-6-bromopyridine manufacturers
- Product
- 2-Acetyl-6-bromopyridine 49669-13-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-20
- Product
- 2-Acetyl-6-bromopyridine 49669-13-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2-Acetyl-6-bromopyridine 49669-13-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12