2-Chloro-5-nitro-benzenesulfonyl chloride
- Product Name
- 2-Chloro-5-nitro-benzenesulfonyl chloride
- CAS No.
- 4533-95-3
- Chemical Name
- 2-Chloro-5-nitro-benzenesulfonyl chloride
- Synonyms
- NSC 350627;2-Chlor-5-nitrobenzolsulfonylchlorid;2-Chloro-5-nitro-benzenesulfonyl chloride;2-chloro-5-nitrobenzenesulphonyl chloride;2-chloro-5-nitrobenzene-1-sulfonyl chloride;Benzenesulfonyl chloride, 2-chloro-5-nitro-;2-chloro-5-nitrobenzene-1-sulphonyl chloride;tianfu-chem-2-Chloro-5-nitro-benzenesulfonyl chloride,4533-95-3
- CBNumber
- CB5648603
- Molecular Formula
- C6H3Cl2NO4S
- Formula Weight
- 256.06
- MOL File
- 4533-95-3.mol
2-Chloro-5-nitro-benzenesulfonyl chloride Property
- Melting point:
- 88-90°C
- Boiling point:
- 371.6±32.0 °C(Predicted)
- Density
- 1.708±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Dichloromethane, Ether, Ethyl Acetate
- form
- Solid
- color
- Off-White to Pale Yellow
- CAS DataBase Reference
- 4533-95-3(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenesulfonyl chloride, 2-chloro-5-nitro- (4533-95-3)
Safety
- RIDADR
- UN3261
- HazardClass
- 8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- R702137
- Product name
- 2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- R702137
- Product name
- 2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
- Purity
- AldrichCPR
- Packaging
- 5mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- C373885
- Product name
- 2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
- Packaging
- 5g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- FC00933
- Product name
- 2-Chloro-5-nitrobenzene sulfonyl chloride
- Packaging
- 5G
- Price
- $450
- Updated
- 2021/12/16
- Product number
- V0500
- Product name
- 2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
- Packaging
- 10g
- Price
- $497
- Updated
- 2021/12/16
2-Chloro-5-nitro-benzenesulfonyl chloride Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
2-Chloro-5-nitrobenzenesulfonyl Chloride (cas# 4533-95-3) is a compound useful in organic synthesis.
Synthesis
6283-25-6
4533-95-3
General procedure for the synthesis of 2-chloro-5-nitrobenzenesulfonyl chloride from 2-chloro-5-nitroaniline: 2-chloro-5-nitrobenzene-1-sulfonyl chloride (37) was prepared as shown in Scheme 5. First, 2-chloro-5-nitroaniline (10 g) was added in batches to hydrochloric acid (100 mL) cooled in an ice bath until complete dissolution. Subsequently, an aqueous sodium nitrite solution (6.0 g, dissolved in 50 mL of water) was added dropwise and the reaction mixture was stirred at 0 °C for 1 hour. Next, the resulting diazonium ion solution was slowly added to acetic acid (500 mL) pre-saturated with sulfur dioxide gas, which contained ice bath cooled copper chloride dihydrate (5 g). The reaction mixture was continued to be stirred at 0°C for 1 hr and then carefully added to the ice-water slurry in batches while maintaining vigorous stirring. The precipitated solid was collected by filtration, washed with water and dried under vacuum to afford the target product 37 as a cream colored powder (8.2 g, 55% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.61 (d, J=3Hz, 1H), 8.16 (dd, J1=9Hz, J2=3Hz, 1H), 7.70 (d, J=9Hz, 1H).
References
[1] Patent: WO2010/123960, 2010, A2. Location in patent: Page/Page column 104-105
[2] Patent: WO2010/123956, 2010, A2. Location in patent: Page/Page column 106-107
[3] Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, p. 478 - 481
[4] Zhurnal Organicheskoi Khimii, 1968, vol. 4, # 3, p. 490 - 493
[5] Journal of Pharmacy and Pharmacology, 2001, vol. 53, # 5, p. 669 - 680
2-Chloro-5-nitro-benzenesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-5-nitro-benzenesulfonyl chloride manufacturers
- Product
- 2-Chloro-5-nitro-benzenesulfonyl chloride 4533-95-3
- Price
- US $25.00-11.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-08-12
- Product
- 2-Chloro-5-nitro-benzenesulfonyl chloride 4533-95-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11